Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder
Abstract
This study investigated whether methylphenidate delivered through a long-acting transdermal system (MTS) would reduce collision rates of young adult drivers with attention-deficit/hyperactivity disorder (ADHD).Seventeen young adults completing the study (mean [SD] age, 20.82 [2.40] years; 14 men and 13 white) met the following inclusion criteria: ADHD diagnoses but not routinely taking ADHD medication, previously responsive to ADHD medication, active drivers with more than 1 collision or citation in the past 2 years, and no significant comorbidities. In this open-labeled, crossover design drivers were randomly assigned either to the no-medication condition for 3 months and then MTS for 3 months or to the reverse sequence. In-car video monitoring of routine driving occurred during these 6 months. At baseline and after each condition, participants completed the Conners Adult ADHD Rating Scale and the Cox Assessment of Risky Driving Scale, and their blood pressure, heart rate, and body weight were monitored.Compared with the no-medication condition, participants in the MTS condition self-reported fewer total ADHD (P < 0.04) and inattentive symptoms (P = 0.014) and a trend for risky driving behaviors (P = 0.059) and had fewer video-recorded collisions (P < 0.005) and other problematic driving events. There were no significant changes in blood pressure, heart rate, or body weight across conditions or any significant skin reactions to the MTS patch.This is the first study demonstrating that long-acting methylphenidate improves activities of daily living among young adults with ADHD. Specifically, methylphenidate improved safety in routine driving while reducing ADHD symptoms with minimal adverse effects.
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MPH has been demonstrated to reduce the risk for drug abuse and risky driving behavior in individuals with ADHD.
“MPH has for example been demonstrated to reduce the risk for drug abuse [74] and risky driving behavior [75] in individuals with ADHD.”
From Risky behavior in gambling tasks in individuals with ADHD–a systematic literature review (2013) · cites this paper as [75]
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- Authors
- Cox, D. J., Davis, M., Mikami, A. Y., Singh, H., Merkel, R. L., & Burket, R.
- Affiliations
- University of Virginia Health System (US)
- University of Virginia (US)
- Corresponding author
- Cox, Daniel J.
- Davis, Margaret
- Singh, Harsimran
- Merkel, Richard L.
- Burket, Roger
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2012-04
- Volume
- 32
- Issue
- 2
- Pages
- 225-230
- ISSN
- 0271-0749 (ISSN-L)
- OpenAlex
- W1978886574
- Cited by
- 69
- References
- 13
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 1
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Traffic and Road Safety
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, young adult drivers, driving safety, traffic accidents, risky driving behavior, inattention, ADHD medication
- MeSH terms
- Activities of Daily Living, Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Automobile Driving, Delayed-Action Preparations, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Psychometrics, Risk-Taking, Video Recording, Treatment Outcome, Cross-Over Studies, Young Adult
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