ApoE4 Allele Is Associated With Late-Life Depression: A Population-Based Study
Abstract
Objective This study aimed to clarify the relationship between the epsilon4 allele and late-life depression, taking into account lipid profile, vascular diseases, and sociodemographics. Methods Using a multilevel stratified random sampling strategy, a total of 500 subjects aged 65 to 74 years were recruited for this cross-sectional study from the official household records of an entire county in southern Taiwan. Depressive symptoms were assessed by the Taiwanese Depression Questionnaire (TDQ). Cognitive function was assessed by the Short Portable Mental Status Questionnaire. Blood samples were collected for the determination of the apolipoprotein E (ApoE) polymorphism and the lipid profile. Results A total of 283 subjects (58.7% male, with a mean age of 69.2 +/- 2.7 years) completed all questionnaires and collection of blood samples. Using the chi(2) test, the overall difference for frequency of the presence of the epsilon4 allele was significant among the severe group (TDQ score >18), moderate group (TDQ score 9-18), and mild group (TDQ score Conclusion The ApoE epsilon4 allele may be correlated with severe depression in the elderly through ways other than the "vascular depression" hypothesis.
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The APOE ε4 allele is associated with late-life depression in humans.
“Population-based studies reveal that apolipoprotein E (APOE) ε4 gene allele is closely associated with late-life depression (LLD).”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [1]
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APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
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The effect of ApoE e4 on blood pressure in patients with and without depression
Hestad, K., Whist, J. E., Farup, P. G., & Engedal, K. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106933 · Cited by 7 · see citing works
- Authors
- Yen, Y.-C., Rebok, G. W., Gallo, J. J., Yang, M.-J., Lung, F.-W., & Shih, C.-H.
- Affiliations
- Johns Hopkins University (US)
- University of Pennsylvania (US)
- Kaohsiung Medical University (TW)
- Corresponding author
- Lung, For-Wey
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 15
- Issue
- 10
- Pages
- 858-868
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2010175928
- Cited by
- 73
- References
- 5
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 5
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E ε4 allele, geriatric depression, late-onset Alzheimer's disease, severe depression, lipid profile, LDL cholesterol, vascular disease, heart disease, genetic risk factors
- MeSH terms
- Age Factors, Aged, Alleles, Cardiovascular Diseases, Cholesterol, Cognition Disorders, Data Collection, Major Depressive Disorder, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Models, Biological, Psychiatric Status Rating Scales, Surveys and Questionnaires, Risk Factors, Sampling Studies, Severity of Illness Index, Taiwan, Triglycerides, Genetic Predisposition to Disease, Apolipoprotein E4
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