The effect of ApoE e4 on blood pressure in patients with and without depression
Open accessAbstract
INTRODUCTION: Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the Apolipoprotein E e4 allele (ApoE e4). The aim of this study was to examine how ApoE e4 was related to blood pressure (BP) in patients with depression and a control group. METHODS: A total of 78 patients, 49 with depression and 29 without, all recruited from the same hospital, underwent ApoE e genotyping (24 had at least one ApoE e4 allele) and examination of BP. RESULTS: In the depression group, but not in the control group, both systolic and diastolic BP were significantly higher in patients with ApoE e4 than in those without. The effect of ApoE e4 on BP differed significantly between the two groups. CONCLUSION: Our findings showed that the effect of ApoE e4 on BP differed between the patients with depression and the control group. In patients with depression, ApoE e4 was associated with an increase in BP. We suggest that patients with depression and ApoE e4-positive status are particularly prone to develop BP elevation.
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Higher diastolic blood pressure has been observed in some cohorts.
“Diastolic blood pressure was elevated for male APOE4 carriers relative to non-carriers, consistent with a documented susceptibility of APOE4 carriers to cardiovascular risk factors [54], including higher diastolic blood pressure observed in some cohorts [55–57].”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [55]
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- [27]Hestad K Kveberg B Engedal K Low blood pressure is a better predictor of cognitive deficits than the apolipoprotein e4 allele in the oldest old Acta Neurol Scand 2005 111 5 323 328 15819712
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“Diastolic blood pressure was elevated for male APOE4 carriers relative to non-carriers, consistent with a documented susceptibility of APOE4 carriers to cardiovascular risk factors [54], including higher diastolic blood pressure observed in some cohorts [55–57].”
Result
- Authors
- Hestad, K., Whist, J. E., Farup, P. G., & Engedal, K.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Innlandet Hospital Trust (NO)
- Corresponding author
- Hestad, Knut
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2016-06
- Volume
- 12
- Pages
- 1365
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC4913981
- OpenAlex
- W2443471578
- Cited by
- 7
- References
- 26
- Citations by year
- 2024: 2 · 2022: 1 · 2020: 2 · 2018: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (acceptedVersion, cc-by-nc)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Funders
- Sykehuset Innlandet HF
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- apolipoprotein E e4, APOE genotype, blood pressure, hypertension, depression, cardiovascular risk, systolic blood pressure, diastolic blood pressure, genetic risk factors
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