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Cited by 37Electrolyte and hormonal disordersThermoregulation and physiological responsesExercise and Physiological Responses

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Incidence of Exercise-Associated Hyponatremia and Its Association With Nonosmotic Stimuli of Arginine Vasopressin in the GNW100s Ultra-endurance Marathon

Cairns, Ross S., Hew-Butler, Tamara·2015·Clinical Journal of Sport Medicine
DOI 10.1097/jsm.0000000000000144
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Abstract

OBJECTIVES: (1) To examine the incidence of exercise-associated hyponatremia (EAH) during and after an ultramarathon and (2) to evaluate hypothesized nonosmotic stimuli [interleukin-6 (IL-6), hypoglycemia, ambient temperature] with arginine vasopressin (AVP) concentrations in hyponatremic versus normonatremic runners. DESIGN: Prospective cohort study. SETTING: The Great North Walk 100s ultramarathons. PARTICIPANTS: Fifteen runners participated in either 103.7- or 173.7-km ultramarathons. MAIN OUTCOME MEASURES: Serum sodium concentration ([Na]) and AVP concentration. Secondary outcome measures included IL-6, blood glucose, ambient temperature, weight change, fluid consumption, and use of nonsteroidal anti-inflammatory drugs (NSAIDs). RESULTS: Postrace EAH incidence was 4 of 15 runners, whereas EAH incidence at any point during the race was in 10 of 15 runners. A significant positive correlation was noted between AVP and IL-6 (r = 0.31, P < 0.05) but not between AVP and blood glucose (r = 0.09, nonsignificant) or ambient temperature (r = -0.12, NS). Subgroup analysis revealed that the correlation between AVP and IL-6 was significant in hyponatremic (r = 0.37, P < 0.05) but not normonatremic runners (r = 0.31, NS). Hyponatremic runners lost less weight than normonatremic runners (2.5 vs. 3.7 kg, P < 0.05, respectively) despite similar fluid consumption. Seven of 10 hyponatremic runners consumed NSAIDs versus 0 of 5 normonatremic runners. CONCLUSIONS: Exercise-associated hyponatremia incidence mid-race is higher than postrace, suggesting that 40% of runners are able to self-correct low serum [Na] status during an ultramarathon. Interleukin-6 seems to be the main nonosmotic stimulus associated with AVP in hyponatremic runners. Nonsteroidal anti-inflammatory ingestion is more common in hyponatremic versus normonatremic runners. CLINICAL RELEVANCE: Exercise-associated hyponatremia associated with nonosmotic AVP secretion may be more common during ultramarathon races without discriminatory clinical symptomatology.

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Metadata

Authors
Cairns, R. S., & Hew-Butler, T.
Affiliations
Oakland University (US)
Corresponding author
Cairns, Ross S.
Venue
Clinical Journal of Sport Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-07
Volume
25
Issue
4
Pages
347-354
ISSN
1050-642X (ISSN-L)
DOI
10.1097/jsm.0000000000000144
OpenAlex
W2320619157
Cited by
37
References
41
Citations by year
2025: 1 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 5
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Journal of Sport Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
exercise-associated hyponatremia, vasopressin, interleukin-6, ultramarathon, marathon runners, serum sodium, hypoglycemia, ambient temperature, weight loss, NSAID use, fluid intake
MeSH terms
Adult, Anti-Inflammatory Agents, Non-Steroidal, Arginine Vasopressin, Blood Glucose, Body Weight, Drinking Behavior, Humans, Hypoglycemia, Hyponatremia, Middle Aged, Prospective Studies, Risk Factors, Running, Sodium, Temperature, Cohort Studies, Interleukin-6, Incidence, Linear Models

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