Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease.
Abstract
Background: Coronary atherosclerosis is a systemic chronic inflammatory disease with variable occurrence and progression. Some laboratory parameters, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level, are used to evaluate the degree of inflammation and the severity of coronary artery disease (CAD). The neutrophil*platelet/lymphocyte is a novel systemic immune-inflammation index (SII), and its relationship with the development and severity of CAD is unclear. Objective: To investigate the association between the SII and the severity of CAD. Methods: Three-hundred and ninety-five patients who underwent coronary angiography were enrolled; among whom, 285 patients were included in the CAD group and 110 patients were included in the non-CAD group according to the WHO guidelines. Patients with CAD were further divided according to the Gensini score into the severe coronary stenosis group and the mild coronary stenosis group. The SII was calculated using the following formula: neutrophil*platelet/lymphocyte. Results: When the cutoff value of the SII was set at 439.44, the predictive power of CAD was the highest, with a sensitivity and specificity of 64.6 and 68.2%, respectively. When the cutoff value of the SII was set at 652.83, the predictive power of severe coronary stenosis was the highest, with a sensitivity and specificity of 71.0 and 86.0%, respectively. The area under the curve of the SII in predicting severe coronary stenosis was greater than that of the NLR, PLR and CRP level. Conclusion: The SII is an independent risk factor for the occurrence and severity of CAD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In many inflammatory diseases, including cancers, coronary heart disease, and COVID-19, SII, SIRI, MHR, NHR, LHR, and PHR are considered independent predictors.
“in many inflammatory diseases, including cancers, coronary heart disease, and coronavirus disease 2019 (COVID-19), they are considered independent predictors (24, 35–37).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
The SII can better reflect the body's immune and inflammatory states than any aforementioned markers in isolation.
“It can better reflect the body’s immune and inflammatory states than any aforementioned markers in isolation.”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
Previous studies have found that the SII has an important role in predicting the prognosis of patients with some physical diseases, such as tumors, cerebral infarction, cardiovascular disease, and acute pancreatitis.
“Previous studies have found that the SII has an important role in predicting the prognosis of patients with some physical diseases, such as tumors, cerebral infarction, cardiovascular disease, and acute pancreatitis (18, 20, 21, 36).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
Cites
Global Burden of Cardiovascular Diseases
Yusuf, S., Reddy, S., Ôunpuu, S., & Anand, S. S. (2001) · Circulation · doi:10.1161/hc4601.099487 · Cited by 2,979 · see citing works
Atherosclerosis: current pathogenesis and therapeutic options
Weber, C., & Noels, H. (2011) · Nature Medicine · doi:10.1038/nm.2538 · Cited by 2,203 · see citing works
A more meaningful scoring system for determining the severity of coronary heart disease
Gensini, G. G. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80105-2 · Cited by 2,171 · see citing works
Guidelines for percutaneous transluminal coronary angioplasty
Ryan, T. J. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90431-7 · Cited by 1,032 · see citing works
Cardioimmunology: the immune system in cardiac homeostasis and disease
Świrski, F. K., & Nahrendorf, M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 853 · see citing works
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Weber, C., Zernecke, A., & Libby, P. (2008) · Nature reviews. Immunology · doi:10.1038/nri2415 · Cited by 777 · see citing works
Yang, Y., Wu, C., Hsu, P., Chen, S., Huang, S., Chan, W., Lin, S., Chou, C., Chen, J., Pan, J., et al. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13230 · Cited by 717 · see citing works
Neutrophils as regulators of cardiovascular inflammation
Silvestre-Roig, C., Braster, Q., Ortega‐Gómez, A., & Soehnlein, O. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0326-7 · Cited by 608 · see citing works
Ryan, T. J., Bauman, W. B., Kennedy, J. W., Kereiakes, D. J., King, S. B., McCallister, B. D., Smith, S. C., & Ullyot, D. J. (1993) · Circulation · doi:10.1161/01.cir.88.6.2987 · Cited by 397 · see citing works
SULLIVAN, D. R., Marwick, T. H., & Freedman, B. (1990) · American Heart Journal · doi:10.1016/s0002-8703(05)80173-5 · Cited by 276 · see citing works
C-reactive protein elevation and disease activity in patients with coronary artery disease
Arroyo‐Espliguero, R. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.017 · Cited by 228 · see citing works
Role of Platelets in the Pathophysiology of Acute Coronary Syndrome
Maßberg, S., Schulz, C., & Gawaz, M. (2003) · Seminars in Vascular Medicine · doi:10.1055/s-2003-40673 · Cited by 130 · see citing works
Wang, Q., & Zhu, D. (2019) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2019.05.03 · Cited by 115 · see citing works
Sarı, İ., Sünbül, M., Mammadov, C., Durmuş, E., Bozbay, M., Kıvrak, T., & Gerin, F. (2015) · Kardiologia Polska · doi:10.5603/kp.a2015.0098 · Cited by 102 · see citing works
Increased Mean Platelet Volume in Patients With Acute Coronary Syndromes
Lippi, G., Filippozzi, L., Salvagno, G. L., Montagnana, M., Franchini, M., Guidi, G. C., & Targher, G. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.9.1441 · Cited by 81 · see citing works
Ateş, A. H., Canpolat, U., Yorgun, H., Kaya, E. B., Sunman, H., Demiri, E., Taher, A. T., Hazırolan, T., Aytemir, K., Tokgözoğlu, L. S., et al. (2011) · PubMed · Cited by 73 · see citing works
Terregino, C. A., Lubkin, C., & Thom, S. R. (1997) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(97)70353-6 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., Paleczny, J., Junka, A., Dąbrowski, M., & Jankowski, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179553 · Cited by 324 · see citing works
Ye, Z., Hu, T., Wang, J., Xiao, R., Liao, X., Liu, M., & Sun, Z. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.933913 · Cited by 326 · see citing works
İslam, M. M., Satıcı, M. O., & Eroğlu, S. E. (2024) · Turkish Journal of Emergency Medicine · doi:10.4103/tjem.tjem_198_23 · Cited by 290 · see citing works
Murat, B., Murat, S., Özgeyik, M., & Bilgin, M. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13872 · Cited by 152 · see citing works
Wei, Y., Wang, T., Li, G., Feng, J., Deng, L., Xu, H., Yin, L., Ma, J., Chen, D., & Chen, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.941728 · Cited by 99 · see citing works
Di, X., Liu, S., Xiang, L., & Jin, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1116224 · Cited by 96 · see citing works
Xiao, S., Wang, X., Zhang, G., Tong, M., Chen, J., Zhou, Y., Ji, Q., & Liu, N. (2023) · Mediators of Inflammation · doi:10.1155/2023/1966680 · Cited by 82 · see citing works
Liu, Y., Liu, J., Liu, L., Cao, S., Jin, T., Chen, L., Wu, G., & Zong, G. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s421491 · Cited by 81 · see citing works
Self-citationWang, H., Nie, H., Bu, G., Tong, X., & Bai, X. (2023) · European journal of medical research · doi:10.1186/s40001-023-01529-1 · Cited by 80 · see citing works
The systemic immune-inflammation index in predicting sepsis mortality
Mangalesh, S., Dudani, S., & Malik, A. (2022) · Postgraduate Medicine · doi:10.1080/00325481.2022.2140535 · Cited by 75 · see citing works
Tuzimek, A., Dziedzic, E. A., Beck, J. L., & Kochman, W. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s454117 · Cited by 73 · see citing works
Zhao, Z., Zhang, X., Sun, T., Huang, X., Ma, M., Yang, S., & Zhou, Y. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14100 · Cited by 72 · see citing works
Zhang, C., Li, M., Liu, L., Deng, L., Yulei, X., Zhong, Y., Liao, B., Yu, L., & Feng, J. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03849-4 · Cited by 51 · see citing works
Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., Dąbrowski, M., & Jankowski, P. (2022) · Nutrients · doi:10.3390/nu14194212 · Cited by 49 · see citing works
Orhan, A. L., Şaylık, F., Çiçek, V., Akbulut, T., Selçuk, M., & Çınar, T. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02103-1 · Cited by 43 · see citing works
Mangalesh, S., Dudani, S., & Mahesh, N. K. (2023) · Angiology · doi:10.1177/00033197231151564 · Cited by 41 · see citing works
Çetınkaya, Z., Keleşoğlu, Ş., Tunçay, A., Yılmaz, Y., Karaca, Y., Karasu, M., Seçen, Ö., Çınar, A., Harman, M., Şahin, Ş., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051295 · Cited by 39 · see citing works
Shi, S., Kong, S., Ni, W., Lu, Y., Li, J., Huang, Y., Chen, J., Lin, K., Li, Y., Ke, J., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s397615 · Cited by 34 · see citing works
Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., & Kochman, W. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041369 · Cited by 33 · see citing works
Ma, L.-L., Xiao, H., Zhang, J., Liu, Y., Hu, L., Chen, N., Chu, X., Dong, J., & Yan, Y. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.09.025 · Cited by 30 · see citing works
Self-citationSun, H., Liu, H., Li, J., Kou, J., & Yang, C. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s479253 · Cited by 29 · see citing works
Urbanowicz, T. K., Michalak, M., Al-Imam, A., Olasińska‐Wiśniewska, A., Rodzki, M., Witkowska, A., Haneya, A., Buczkowski, P., Perek, B., & Jemielity, M. (2022) · Diagnostics · doi:10.3390/diagnostics12030634 · Cited by 30 · see citing works
Liu, W., Zheng, S., & Du, X. (2024) · PubMed Central · doi:10.2147/dmso.s447026 · Cited by 26 · see citing works
Zhang, Y., Liu, W., Yu, H., Chen, Z., Zhang, C., Ti, Y., & Bu, P. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.811079 · Cited by 25 · see citing works
Wang, C., Yan, W., Ren, M., & Zhong, L. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1369 · Cited by 24 · see citing works
Yu, F., & Peng, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38273 · Cited by 24 · see citing works
Complete Blood Count-Derived Inflammation Indices and Retinal Vein Occlusion: A Case–Control Study
Kazantzis, D., Machairoudia, G., Kroupis, C., Theodossiadis, G., Theodossiadis, P., & Chatziralli, I. (2022) · Ophthalmology and Therapy · doi:10.1007/s40123-022-00511-0 · Cited by 22 · see citing works
Liu, Y., Ye, T., Chen, L., Xu, B., Wu, G., & Zong, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109594 · Cited by 22 · see citing works
Self-citationGuo, J., Xu, R., Liu, R., Lai, W., Hu, C., He, H., Zhang, G., Li, G., Zheng, W., & Zhang, R. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04888-3 · Cited by 22 · see citing works
Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer’s Disease Severity
Algul, F. E., & Kaplan, Y. (2024) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887241280880 · Cited by 22 · see citing works
Prognostic Value of Multiple Complete Blood Count-Derived Indices in Intermediate Coronary Lesions
Yang, Y., Song, C., Jia, L., Dong, Q., Song, W., Yin, D., & Dou, K. (2023) · Angiology · doi:10.1177/00033197231198678 · Cited by 20 · see citing works
Çelik, M. C., Karayiğit, O., Özkan, C., Dolu, A. K., & Kalçık, M. (2022) · Angiology · doi:10.1177/00033197221115562 · Cited by 19 · see citing works
Li, H., Meng, S., Chen, W., Lei, X., Kong, X., & Zhu, H. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s413538 · Cited by 18 · see citing works
Wang, H., Huang, Z., Wang, J., Yue, S., Hou, Y., Ren, R., Zhang, Y., Cheng, Y., Zhang, R., & Mu, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-82826-5 · Cited by 18 · see citing works
Özkan, E., Erdoğan, A., Karagöz, A., & Tanboğa, İ. H. (2023) · Angiology · doi:10.1177/00033197231170979 · Cited by 17 · see citing works
Liu, Y., Ye, T., Chen, K., Wu, G., Yang, X., Wang, X., & Zong, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.966299 · Cited by 16 · see citing works
Self-citationXu, X., Xie, Y., Gu, X., Zhou, Y., Kang, Y. M., Liu, J., Lai, W., Lu, H., Chen, S., Xu, J., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s425189 · Cited by 15 · see citing works
Self-citationBabeş, E. E., Radu, A.-F., Cretu, N. A., Bungau, G. S., Diaconu, C. C., Ţiţ, D. M., & Babeş, V. V. (2025) · Medical Sciences · doi:10.3390/medsci13030116 · Cited by 15 · see citing works
Relationship Between Inflammatory Readings and the Degree of Coronary Atherosclerosis (Pilot Study)
Liuizė, A., Mongirdienė, A., & Laukaitienė, J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm14010122 · Cited by 15 · see citing works
Tian, S.-Y. (2023) · The Heart Surgery Forum · doi:10.1532/hsf.5303 · Cited by 14 · see citing works
Zhao, W.-X., Wu, Z., Zhao, N. O., Diao, Y., Lan, Y., & Li, Y. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2506202 · Cited by 14 · see citing works
Qiu, J., Huang, X., Kuang, M.-B., Wang, C., Yu, C., He, S.-M., Xie, G., Wu, Z.-Y., Sheng, G.-T., & Zou, Y. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14904 · Cited by 17 · see citing works
Yu, L. J., Meng, Y., Yang, M. W., & Yang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1528690 · Cited by 14 · see citing works
Li, J., Hou, D., Li, J., Li, R., & Sun, M. Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-96090-8 · Cited by 17 · see citing works
Dolapoğlu, A., & Avcı, E. (2024) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-024-02691-1 · Cited by 13 · see citing works
Qiu, L., Ren, Y., Li, J., Li, M., Li, W., Qin, L., Ning, C., Zhang, J., & Gao, F. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.06.003 · Cited by 13 · see citing works
Yılmaz, Y., & Keleşoğlu, Ş. (2024) · Angiology · doi:10.1177/00033197241258529 · Cited by 13 · see citing works
Demirtola, A. İ., Erdöl, M. A., Mammadli, A., Ertem, A. G., Yayla, Ç., & Akçay, A. B. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.05.015 · Cited by 12 · see citing works
Dolu, A. K., Akçay, F. A., Atalay, M., & Karaca, M. (2023) · The Journal of Tehran University Heart Center · doi:10.18502/jthc.v18i2.13317 · Cited by 12 · see citing works
Sert, E. T., Kokulu, K., Mutlu, H., Gül, M., & Uslu, Y. (2023) · Resuscitation Plus · doi:10.1016/j.resplu.2023.100382 · Cited by 11 · see citing works
The Role of Systemic Immune-Inflammation Index (SII) in Diagnosing Pediatric Acute Appendicitis
Fırıncı, B., Aydın, Ç., Yunluel, D., Ibrahim, A. H., Yiğiter, M., & Ahişkalıoğlu, A. (2025) · Diagnostics · doi:10.3390/diagnostics15151942 · Cited by 10 · see citing works
Ayhan, M. G., Öztürk, H. D., & İnanlı, İ. (2025) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.24.1260 · Cited by 10 · see citing works
Associations between multiple inflammatory biomarkers and the risk of developing kidney stones
Lee, J. H., & Bae, H. (2025) · BMC Urology · doi:10.1186/s12894-025-01735-5 · Cited by 10 · see citing works
Zhao, Z., Lian, H., Liu, Y., Sun, L., & Zhang, Y. (2023) · Coronary Artery Disease · doi:10.1097/mca.0000000000001239 · Cited by 9 · see citing works
Self-citationYe, J., Xu, D., Yuan, R., Cao, S., Wang, Z., Wang, Y., Li, C., & Zong, G. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s462265 · Cited by 9 · see citing works
Self-citationJin, X., Liu, Y., Jia, W., Xu, R., Guan, X., Cui, M., Zhang, H., Wu, H., Wei, L., & Qi, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s507696 · Cited by 9 · see citing works
Self-citationElgenidy, A., Alomarı, O., Emad, T., Kamal, S. K., Ghanam, I. E. A., Sherif, A., Al‐kurdi, M. A., Helal, A. A., Omar, Y. M., & Ramadan, M. R. (2024) · Gastroenterology & Endoscopy · doi:10.1016/j.gande.2024.10.003 · Cited by 9 · see citing works
Aktemur, T., Demirci, G., Taşbulak, Ö., Kahraman, S., Avcı, Y., Çelik, Ö., Yalçın, A. A., & Ertürk, M. (2023) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.03.012 · Cited by 8 · see citing works
Xie, Y., Cen, H., Wang, L., Cheng, K., Huang, L., Lu, H., Ji, L., Chen, Y., Zhou, Z., Yang, Z., et al. (2023) · Angiology · doi:10.1177/00033197231197804 · Cited by 8 · see citing works
Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., & Zong, G. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12348 · Cited by 8 · see citing works
Self-citationGenç, Ö., Yıldırım, A., Erdoğan, A., İbişoğlu, E., Güler, Y., Çapar, G., Göksu, M. M., Akgün, H., Acar, G., Ozdogan, G. C., et al. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14332 · Cited by 8 · see citing works
Agyeman, K. B., Shafi, N., Contreras, R., Parackal, V., Shah, D. N., Gurram, A., Keetha, N. R., & Ameen, D. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42736 · Cited by 8 · see citing works
Lu, Y., Meng, W., Zhang, K., Zhang, P., Liu, D., Jiang, Z., Zhang, T., & Zhang, J. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133529 · Cited by 7 · see citing works
Zhang, F., Yu, J., Li, G., Fu, S., Xiao, H., Yang, Y., Liang, Y., Chen, Y., & Luo, X. (2024) · Hemodialysis International · doi:10.1111/hdi.13145 · Cited by 7 · see citing works
Ma, X., Mo, C., Li, Y., & Gui, C. (2023) · Coronary Artery Disease · doi:10.1097/mca.0000000000001253 · Cited by 7 · see citing works
Li, M., Li, M., Wang, Z., & Zhang, Y. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s493735 · Cited by 7 · see citing works
Zhao, Y., Zhao, S., Shi, Y., Ma, Q., Zheng, Z., Wang, P., & Liu, J. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s486692 · Cited by 6 · see citing works
Akyel, S., Korkmaz, A., & Yıldız, A. (2025) · Diagnostics · doi:10.3390/diagnostics15020162 · Cited by 6 · see citing works
Bai, S., Liu, Y., Zhang, C., & Ren, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1500534 · Cited by 6 · see citing works
Self-citationKaşak, M., Okumuş, H. G., Çelik, Y., Kırşan, F. Z., Öztürk, Y., & Efe, A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1621767 · Cited by 8 · see citing works
Özde, Ş., Aktüre, G., Özel, M. A., Yavuzyılmaz, F., Arslanoğlu, İ., Özde, C., Kayapınar, O., & Coşkun, G. (2024) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2024-0043 · Cited by 6 · see citing works
Tolstik, T. V., Kirichenko, T. V., Markin, A. M., Bogatyreva, A. I., Markina, Y. V., Kiseleva, D. G., Shaposhnikova, N. N., Starodubova, A. V., & Orekhov, A. N. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1362955 · Cited by 6 · see citing works
Atherosclerotic burden and systemic immune inflammation index
Yavuz, Ş., & Engin, M. (2022) · Echocardiography · doi:10.1111/echo.15343 · Cited by 6 · see citing works
Hu, Y., Yao, Y., Xie, Y., Liu, Q., He, H., Li, Z., Chen, M., & Zhu, L. (2024) · BMC Oral Health · doi:10.1186/s12903-024-05335-x · Cited by 5 · see citing works
ÇANAKCI, H., Yazıcı, H., Yayman, S., Tulacı, K. G., Arslan, E., & Hızlı, Ö. (2025) · Clinical Otolaryngology · doi:10.1111/coa.70024 · Cited by 5 · see citing works
Topaloğlu, Ö., Seyis, K. N., Karapolat, S., Topaloglu, E. S., Türkyılmaz, A., Alkas, B. K., Gümüş, A., Türüt, H., & Tekinbaş, C. (2025) · Diagnostics · doi:10.3390/diagnostics15222902 · Cited by 5 · see citing works
Guo, F., Xu, M., Tu, Q., Yang, H., Linghu, K., Li, B., Zhang, J., Luo, Y., & Huang, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1646944 · Cited by 5 · see citing works
Huo, L. K., Chen, K. Y., Tse, G., & Liu, T. (2024) · Medicine · doi:10.1097/md.0000000000038118 · Cited by 5 · see citing works
Bayraktar, M. F., & Coşgun, M. (2024) · Northwestern Medical Journal · doi:10.54307/2024.nwmj.116 · Cited by 5 · see citing works
Cai, L., Yan, J., Sun, L., & Dan, W. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1600097 · Cited by 4 · see citing works
Atasoy, M. S., & Güven, H. (2025) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2025.02.050 · Cited by 4 · see citing works
Lee, C., Yang, S., Huang, J., & Chang, C. (2024) · Diagnostics · doi:10.3390/diagnostics14060586 · Cited by 4 · see citing works
Zhao, L., Zhang, X., & Chen, L. (2024) · Medicine · doi:10.1097/md.0000000000039711 · Cited by 4 · see citing works
Self-citationSerhatlıoğlu, F., Çetınkaya, Z., & Yılmaz, Y. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11110337 · Cited by 4 · see citing works
Aydemir, S., Aydın, S. Ş., Altınkaya, O., Aksakal, E., & Özmen, M. (2025) · Angiology · doi:10.1177/00033197251320141 · Cited by 4 · see citing works
Lee, C., Yang, S., Chang, Y., Huang, J., & Chang, C. (2024) · Diagnostics · doi:10.3390/diagnostics14131349 · Cited by 4 · see citing works
Ting, K.-H., Yang, P., Huang, J., Lee, C.-Y., Su, S., & Yang, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316112 · Cited by 3 · see citing works
Sun, J., Zhang, X.-L., Yang, M., Yang, S., & Zeng, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1732824 · Cited by 3 · see citing works
Yang, C., Cai, Q., Xie, Y., Luo, L., Huang, Y., Zhang, R., & Liu, Y. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s571202 · Cited by 3 · see citing works
Self-citationLiu, M., Mao, J., Wang, X., Wang, K., & 王恒和 (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1778315 · Cited by 3 · see citing works
Oğuz, M., & Torun, A. (2023) · Cureus · doi:10.7759/cureus.42833 · Cited by 3 · see citing works
Ye, J., Yuan, R., Liu, Y., Wang, W., Xu, D., Li, Y., Wu, G., & Zong, G. (2025) · European journal of medical research · doi:10.1186/s40001-025-02624-1 · Cited by 3 · see citing works
Self-citationCai, M., Sun, J., Wu, J., Liu, Y., & Huang, Y. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1596223 · Cited by 3 · see citing works
Self-citationDziedzic, E. A., Czernicka, A., Gąsior, J. S., Szamreta-Siwicka, A., Wodejko-Kucharska, B., Maciński, P., Arbaszewska, A., Adler, K., Osiecki, A., & Kochman, W. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134537 · Cited by 3 · see citing works
Demirci, G., Şahin, A. A., Aktemur, T., Demir, A. R., Çetin, İ., Karakurt, H., Arslan, E., Işık, A., Gürbak, İ., & Ertürk, M. (2023) · Biomarkers in Medicine · doi:10.2217/bmm-2023-0208 · Cited by 3 · see citing works
Sheng, J., Yang, S., Gu, N., Deng, C., Shen, Y., Xia, Q., Zhao, Y., Wang, X., Deng, Y. S., Zhao, R., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36486 · Cited by 3 · see citing works
Ting, K.-H., Lu, Y., Lin, C.-W., Lee, C.-Y., Huang, J., Hsin, C., & Yang, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-97516-z · Cited by 2 · see citing works
Liu, X.-Y., & Yao, K. (2025) · Mediators of Inflammation · doi:10.1155/mi/1989715 · Cited by 2 · see citing works
Jiang, X., Lei, Y., Yin, Y., Ma, F., Liu, G., & Zheng, M. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10653-8 · Cited by 2 · see citing works
Çiçek, S., Coşkun, E. İ., Abdurahmanova, N., & Yılmaz, E. (2025) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-025-08163-8 · Cited by 2 · see citing works
- Authors
- Liu, Y., Ye, T., Chen, L., Jin, T., Sheng, Y., Wu, G., & Zong, G.
- Affiliations
- Wuxi Clinical College of Anhui Medical University, Wuxi 214044, China
- Corresponding author
- Liu, Yehong
- Ye, Ting
- Venue
- Coronary Artery Disease
- Published
- 2021-03-16
- Volume
- 32
- Issue
- 8
- Pages
- 715-720
- ISSN
- 0954-6928 (ISSN-L)
- OpenAlex
- W3143380783
- Cited by
- 179
- References
- 17
- Citations by year
- 2026: 26 · 2025: 46 · 2024: 52 · 2023: 35 · 2022: 18 · 2021: 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coronary Artery Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- systemic immune-inflammation index, coronary stenosis severity, coronary artery disease, systemic inflammation, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, Gensini score, risk prediction
- MeSH terms
- Aged, Coronary Disease, Female, Humans, Inflammation, Male, Middle Aged, Risk Factors, Severity of Illness Index, Coronary Stenosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
