Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa
Abstract
BACKGROUND AND AIM: Gut flora/host interactions are fundamental for the maintenance of homeostasis. Evidence of possible regulatory effect of commensal bacteria on proliferative disorders of the colon is mounting. In this study, we explored the hypothesis that precancerous lesions, such as adenomas, present alteration of the local microflora and lead to an overproduction of antibacterial molecules of the innate immunity, namely α-defensins. Thus, the host-bacteria misbalance could represent a potential procarcinogenic factor. METHODS: Biopsies from adenomatous polyps and normal mucosa, in the rectum-sigmoid colon, were collected from 51 patients. Concentration of mucosal bacteria was evaluated by real-time polymerase chain reaction after extraction of total DNA. Total RNA was also extracted, and the defensin α-1, defensin-5, and defensin-6 gene expressions were evaluated by real-time polymerase chain reaction. Immunohistochemical study has been carried out to evaluate protein production and location. Antibacterial activity of adenomatous polyps mucosa was evaluated in vitro. RESULTS: Biopsies from adenomatous polyps had a significant relative reduction of mucosa adherent bacteria compared with normal tissue (20-fold relative reduction, P<0.05). Concomitantly, α-defensin expression and production were significantly increased in adenomas. Adenoma mucosa showed increased antibacterial activity in vitro compared with normal mucosa. CONCLUSIONS: Microflora dysbiosis occurs at the mucosal surface in colonic adenomas, and may represent a potential factor for dysplastic cell proliferation. Further studies are needed to confirm and define the role of this mechanism in colon carcinogenesis and the potential applications in the clinical setting.
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α-defensin expression is significantly increased in adenomas, resulting in increased antibacterial activity compared with normal mucosa.
“α-defensin expression is significantly increased in adenomas resulting in an increased antibacterial activity compared with normal mucosa.93”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [93]
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- Authors
- Pagnini, C., Corleto, V. D., Mangoni, M. L., Pilozzi, E., Torre, M. S., Marchese, R., Carnuccio, A., Giulio, E. D., & Fave, G. D.
- Affiliations
- Azienda Ospedaliera Sant'Andrea (IT)
- Ospedale San Pietro Fatebenefratelli (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Pagnini, Cristiano
- Corleto, Vito D.
- Carnuccio, Antonella
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2011-08
- Volume
- 45
- Issue
- 7
- Pages
- 602-610
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2326249605
- Cited by
- 43
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2021: 1 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- colonic adenoma, gut microbiota, dysbiosis, alpha-defensins, defensin-1, innate immunity, antibacterial activity, colon carcinogenesis, precancerous lesions, host-microbe interactions
- MeSH terms
- Adenoma, Bacteria, Biopsy, Colon, Colonic Neoplasms, Colonic Polyps, DNA, Bacterial, Humans, Immunity, Innate, Intestinal Mucosa, Microbial Sensitivity Tests, Up-Regulation, Polymerase Chain Reaction, alpha-Defensins
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