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Cited by 236

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Regulation of muscle growth in neonates

Open access
Davis, Teresa A, Fiorotto, Marta L·2009·Current Opinion in Clinical Nutrition & Metabolic Care

Abstract

PURPOSE OF REVIEW: This review reports recent findings on the multiple factors that regulate skeletal muscle growth in neonates. RECENT FINDINGS: Skeletal muscle is the fastest growing protein mass in neonates. The high rate of neonatal muscle growth is due to accelerated rates of protein synthesis accompanied by the rapid accumulation of muscle nuclei. Feeding profoundly stimulates muscle protein synthesis in neonates and the response decreases with age. The feeding-induced stimulation of muscle protein synthesis is modulated by enhanced sensitivity to the postprandial rise in insulin and amino acids. Insulin and amino acid signaling components have been identified that are involved in the feeding-induced stimulation of protein synthesis in neonatal muscle. The enhanced activation of these signaling components in skeletal muscle of the neonate contributes to the high rate of muscle protein synthesis and rapid gain in muscle protein mass in neonates. SUMMARY: Recent findings suggest that the immature muscle has a heightened capacity to activate signaling cascades that promote translation initiation in response to the postprandial rise in insulin and amino acids thereby enabling their efficient utilization for muscle growth. This capacity is further supported by enhanced satellite cell proliferation, but how these two processes are linked remains to be established.

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Metadata

Authors
Davis, T. A., & Fiorotto, M. L.
Venue
Current Opinion in Clinical Nutrition & Metabolic Care
Published
2009-01
Volume
12
Issue
1
Pages
78-85
ISSN
1363-1950 (ISSN-L)
OpenAlex
W2003453262
Cited by
236
References
11
FWCI
2.63
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Regulation of muscle growth in neonates. https://app.cochat.ai/papers/10.1097/mco.0b013e32831cef9f
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Davis, T. A., & Fiorotto, M. L. (2009). Regulation of muscle growth in neonates. Current Opinion in Clinical Nutrition & Metabolic Care. https://doi.org/10.1097/mco.0b013e32831cef9f

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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