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Cited by 234

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Epidemiology of myosteatosis

Open access
Miljkovic, Iva, Zmuda, Joseph M·2010·Current Opinion in Clinical Nutrition and Metabolic Care

Abstract

PURPOSE OF REVIEW: To summarize the epidemiology of myosteatosis and its association with diabetes. RECENT FINDINGS: The role of myosteatosis (fat infiltration in skeletal muscle) in diabetes has received considerable attention. There is reasonably consistent evidence that myosteatosis contributes to glucose and insulin abnormalities and diabetes, possibly even independent of overall obesity. Novel hypotheses that link myosteatosis with insulin resistance and type 2 diabetes have also recently been proposed. These hypotheses suggest that impaired secretion of adipokines, modulation of nutritive blood flow to skeletal muscle, or both may be of importance for the development of myosteatosis. Recent longitudinal data also suggest that myosteatosis increases with aging, regardless of changes in body weight. SUMMARY: Further studies are needed to identify the specific physiological mechanisms that influence myosteatosis, and the mechanisms that link this fat depot with insulin resistance. Longitudinal studies are also needed to evaluate the remodeling of skeletal muscle fat with aging, across a wider age spectrum, and across different populations, especially those at high risk of developing diabetes. There is also a need to evaluate whether myosteatosis influences the incidence of type 2 diabetes independent of overall adiposity. A better understanding of the factors that regulate myosteatosis may lead to the development of novel therapies that influence a more metabolically 'healthy' skeletal muscle.

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Metadata

Authors
Miljkovic, I., & Zmuda, J. M.
Venue
Current Opinion in Clinical Nutrition and Metabolic Care
Published
2010-05
Volume
13
Issue
3
Pages
260-264
ISSN
1363-1950 (ISSN-L)
OpenAlex
W2039434272
Cited by
234
References
11
FWCI
1.42
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Epidemiology of myosteatosis. https://app.cochat.ai/papers/10.1097/mco.0b013e328337d826
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Miljkovic, I., & Zmuda, J. M. (2010). Epidemiology of myosteatosis. Current Opinion in Clinical Nutrition and Metabolic Care. https://doi.org/10.1097/mco.0b013e328337d826

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.