CoChat
Sign Up
Cited by 172Mindfulness and Compassion InterventionsCancer survivorship and careArt Therapy and Mental Health

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer: A Meta-analysis

Open access
Zhang, Mei-Fen, Wen, Yong-Shan, Liu, Wei-Yan, Peng, Li-Fen, Wu, Xiao-Dan, Liu, Qian-Wen·2015·Medicine
DOI 10.1097/md.0000000000000897PMC PMC4912240
Open this paper in CoChat — free account

Abstract

Anxiety and depression are common among patients with cancer, and are often treated with psychological interventions including mindfulness-based therapy.The aim of the study was to perform a meta-analysis of the effectiveness of mindfulness-based interventions for improving anxiety and depression in patients with cancer.Medline, the Cochrane Library, EMBASE, and Google Scholar were searched. The randomized controlled trials designed for patients diagnosed with cancer were included. Mindfulness-based interventions were provided.The outcomes assessed were the changes in anxiety and depression scores from before to after the intervention. The treatment response was determined by calculating the standardized mean difference (SMD) for individual studies and for pooled study results. Subgroup analyses by cancer type, type of therapy, and length of follow-up were performed.Seven studies, involving 469 participants who received mindfulness-based interventions and 419 participants in a control group, were included in the meta-analysis. Mindfulness-based stress reduction and art therapy were the most common interventions (5/7 studies). All studies reported anxiety and depression scores. The pooled SMD of the change in anxiety significantly favored mindfulness-based therapy over control treatment (-0.75, 95% confidence interval -1.28, -0.22, P = 0.005). Likewise, the pooled SMD of the change in depression also significantly favored mindfulness-based therapy over control (-0.90, 95% confidence interval -1.53, -0.26, P = 0.006). During the length of follow-ups less than 12 weeks, mindfulness-based therapy significantly improved anxiety for follow-up ≤12 weeks after the start of therapy, but not >12 weeks after the start of therapy.There was a lack of consistency between the studies in the type of mindfulness-based/control intervention implemented. Patients had different forms of cancer. Subgroup analyses included a relatively small number of studies and did not account for factors such as the severity of anxiety and/or depression, the time since diagnosis, and cancer stage.Mindfulness-based interventions effectively relieved anxiety and depression among patients with cancer. However, additional research is still warranted to determine how long the beneficial effects of mindfulness-based therapy persist.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/md.0000000000000897

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Figures

FIGURE 1 Flowchart of study selection. RCT = randomized controlled trial.
FIGURE 1 Flowchart of study selection. RCT = randomized controlled trial.CC BY-NC-ND · PubMed Central
FIGURE 2 Forest plot of intervention versus control for the change in anxiety (A) and depression (B). CI = confidence interval, lower limit = lower bound of the 95% CI, SE = standard error of mean, SMD = standardized mean difference, upper limit = upper bound of the 95% CI.
FIGURE 2 Forest plot of intervention versus control for the change in anxiety (A) and depression (B). CI = confidence interval, lower limit = lower bound of the 95% CI, SE = standard error of mean, SMD = standardized mean difference, upper limit = upper bound of the 95% CI.CC BY-NC-ND · PubMed Central
FIGURE 3 Forest plots of sensitivity analysis examining the influence of each study on the pooled estimate for anxiety (A) and depression (B). The leave-one-out approach was used. CI = confidence interval, lower limit = lower bound of the 95% CI, SE = standard error of mean, SMD = standardized mean difference, upper limit = upper bound of the 95% CI.
FIGURE 3 Forest plots of sensitivity analysis examining the influence of each study on the pooled estimate for anxiety (A) and depression (B). The leave-one-out approach was used. CI = confidence interval, lower limit = lower bound of the 95% CI, SE = standard error of mean, SMD = standardized mean difference, upper limit = upper bound of the 95% CI.CC BY-NC-ND · PubMed Central
FIGURE 4 Quality assessment of studies: A, risk of bias graph; B, risk of bias summary.
FIGURE 4 Quality assessment of studies: A, risk of bias graph; B, risk of bias summary.CC BY-NC-ND · PubMed Central
FIGURE 5 Funnel plots for publication bias: A, anxiety; B, depression.
FIGURE 5 Funnel plots for publication bias: A, anxiety; B, depression.CC BY-NC-ND · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

Sorted by citations

See all 172

Related

See all

Metadata

Authors
Zhang, M.-F., Wen, Y.-S., Liu, W.-Y., Peng, L.-F., Wu, X.-D., & Liu, Q.-W.
Affiliations
Sun Yat-sen University (CN)
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-11
Volume
94
Issue
45
Pages
e0897-0
ISSN
0025-7974 (ISSN-L)
DOI
10.1097/md.0000000000000897
PMC
PMC4912240
OpenAlex
W2333874112
Cited by
172
References
26
Citations by year
2026: 4 · 2025: 11 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 23 · 2020: 17 · 2019: 18 · 2018: 13 · 2017: 14 · 2016: 9
FWCI
14.88
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Medicine (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Guangdong Province (S2011010003549)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Clinical Psychology › Art Therapy and Mental Health
Keywords
mindfulness-based interventions, cancer patients, anxiety, depression, mindfulness-based stress reduction, art therapy, psychological intervention, treatment response, follow-up duration
MeSH terms
Anxiety Disorders, Depressive Disorder, Humans, Neoplasms, Mindfulness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review