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Cited by 70Burn Injury Management and OutcomesWound Healing and TreatmentsDermatologic Treatments and Research

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Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm

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Saeidinia, Amin, Keihanian, Faeze, Lashkari, Ardalan Pasdaran, Lahiji, Hossein Ghavvami, Mobayyen, Mohammadreza, Heidarzade, Abtin, Golchai, Javad·2017·Medicine
DOI 10.1097/md.0000000000006168PMC PMC5340444
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Abstract

BACKGROUND: Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in partial thickness burning patients. METHODS: Study population comprised burn victims referred to Velayat Burning Hospital at Rasht, Iran. The intervention group received Centiderm and control group SSD cream. Burn wounds were treated once daily at home. All of the wounds were evaluated till complete healing occurred and at the admission, days 3, 7, 14 objective signs; visual acuity score (VAS) and subjective signs were recorded. Re-epithelialization time and complete healing days were recorded. We used random fixed block for randomization. The randomization sequence was created using the computer. Patients and burning specialist physician were blinded. RESULTS: Seventy-five patients randomized into 2 groups; (40 patients: Centiderm group; 35 patients: SSD group). The mean age of them was 30.67 ± 9.91 years and 19 of them were male (31.7%). Thirty patients in Centiderm and 30 patients in SSD group were analyzed. All of objective and subjective signs and mean of re-epithelialization and complete healing were significantly better in Centiderm group rather than SSD group (P < 0.05). There was no infection in Centiderm group. CONCLUSIONS: We showed that use of Centiderm ointment not only improved the objective and subjective signs in less than 3 days, but also the re-epithelialization and complete healing rather than SSD without any infection in the subjects.

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Metadata

Authors
Saeidinia, A., Keihanian, F., Lashkari, A. P., Lahiji, H. G., Mobayyen, M., Heidarzade, A., & Golchai, J.
Affiliations
Mashhad University of Medical Sciences (IR)
Corresponding author
Keihanian, Faeze
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-03
Volume
96
Issue
9
Pages
e6168
ISSN
0025-7974 (ISSN-L)
DOI
10.1097/md.0000000000006168
PMC
PMC5340444
OpenAlex
W2593644476
Cited by
70
References
65
Citations by year
2026: 3 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 2
FWCI
4.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Medicine (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Guilan University of Medical Sciences
Topics
  • Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
second-degree burns, burn wound healing, Centella asiatica, silver sulfadiazine, topical treatment, re-epithelialization, wound healing time
MeSH terms
Administration, Cutaneous, Adult, Anti-Infective Agents, Local, Burns, Female, Humans, Male, Phytotherapy, Plant Extracts, Silver Sulfadiazine, Triterpenes, Centella, Young Adult, Re-Epithelialization

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