Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

Brinkhaus, B.; Lindner, M.; Schuppan, D.; Hahn, E.G.

doi:10.1016/s0944-7113(00)80065-3

Cited by 525Medicinal Plants and NeuroprotectionPhytochemicals and Medicinal PlantsMedicinal Plant Extracts Effects

Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

Brinkhaus, B., Lindner, M., Schuppan, D., Hahn, E.G.·2000·Phytomedicine

DOI 10.1016/s0944-7113(00)80065-3

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Abstract

Centella asiatica is a medicinal plant that has been in use since prehistoric times. Its active constituents include pentacyclic triterpene derivatives. Studies have been conducted in particular to investigate the madecassosides and asiaticosides. In common with most traditional phytotherapeutic agents, Centella asiatica is used in folk medicine to treat a wide range of indications. In contrast to other medicinal plants, however, Centella asiatica has been subjected to quite extensive experimental and clinical investigations. Studies done in accordance with standardized scientific criteria have shown it to have a positive effect in the treatment of venous insufficiency and striae gravidarum. Centella asiatica also appears to be effective in the treatment of wound healing disturbances. At the present time, clinical studies aimed at investigating the sedative, analgesic, antidepressive, antimicrobial, antiviral and immunomodulatory effects that have been demonstrated experimentally, are still lacking. However, the therapeutic potential of this plant in terms of its efficacy and versatility is such that further detailed research would appear worthwhile.

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Clinical evidence supporting the efficacy of orally administered Centella asiatica for skin health remains limited.
“Despite these promising mechanistic findings, clinical evidence supporting the efficacy of orally administered Centella asiatica for skin health remains limited [28,29].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [28]
C. asiatica extracts positively influence wound healing by improving collagen synthesis and microcirculatory function.
“C. asiatica extracts have been shown to positively influence wound healing by improving collagen synthesis [18,21] and microcirculatory function [22,23].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [18]

Glossary of Indian Medicinal Plants
Chopra, R. N., Nayar, S. L., & Chopra, I. (1956) · Cited by 5,197 · see citing works
A Dictionary of the Economic Products of the Malay Peninsula
(1936) · Nature · doi:10.1038/137255c0 · Cited by 1,562 · see citing works
Chemotaxonomie der Pflanzen
Hegnauer, R. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8649-9_1 · Cited by 1,167 · see citing works
Screening of Indian plants for biological activity: I.
Ml, D., Dhar, M. M., Bn, D., et al. (1968) · PubMed · Cited by 842 · see citing works
Hager's handbuch der pharmazeutischen praxis
Raubenheimer, O. (1928) · The Journal of the American Pharmaceutical Association (1912) · doi:10.1002/jps.3080170327 · Cited by 527 · see citing works
Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine
Tang, W., & Eisenbrand, G. (1992) · Cited by 453 · see citing works
Screening of Indian plants for biological activity. 3.
Ds, B., Ml, D., Dhar, M. M., et al. (1971) · PubMed · Cited by 318 · see citing works
Lehrbuch der biologischen Heilmittel
(1938) · JAMA · doi:10.1001/jama.1938.02790170074033 · Cited by 243 · see citing works
Chinese drugs of plant origin—chemistry, pharmacology and use in traditional and modern medicine
Phillipson, J. D. (1993) · Phytochemistry · doi:10.1016/0031-9422(93)85263-q · Cited by 217 · see citing works
Traditional medicine in Fiji: some herbal folk cures used by Fiji Indians
Singh, Y. N. (1986) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(86)90104-2 · Cited by 158 · see citing works
Pharmaceutical Botany.
(1951) · JAMA · doi:10.1001/jama.1951.03670230079034 · Cited by 153 · see citing works
Stimulation of Collagen Synthesis in Fibroblast Cultures by a Triterpene Extracted fromCentella Asiatica
Maquart, F., Bellon, G., Gillery, P., Wegrowski, Y., & Jp, B. (1990) · Connective Tissue Research · doi:10.3109/03008209009152427 · Cited by 151 · see citing works
Ethno-medico-botanical investigations in Kerala I. Some primitive tribals of western ghats and their herbal medicine
Pushpangadan, P., & Atal, C. K. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90096-5 · Cited by 134 · see citing works
Ethnomedicinal plants of Jaunsar-Bawar Hills, Uttar Pradesh, India
Jain, S. P., & Puri, H. S. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90049-7 · Cited by 123 · see citing works
Studies on some plants used as anticonvulsants in Amerindian and African traditional medicine
Adesina, S. K. (1982) · Fitoterapia · Cited by 117 · see citing works
One Hundred Useful Raw Drugs of the Kani Tribes of Trivandrum Forest Division, Kerala, India
John, D. B. A. (1984) · International Journal of Crude Drug Research · doi:10.3109/13880208409070646 · Cited by 108 · see citing works
An ethnobotanical study of the Kumaon region of India
Shah, N. C., & Joshi, M. C. (1971) · Economic Botany · doi:10.1007/bf02985209 · Cited by 96 · see citing works
Ethnobotany of Jumla District, Nepal
Manandhar, N. P. (1986) · International Journal of Crude Drug Research · doi:10.3109/13880208609083311 · Cited by 91 · see citing works
Antihepatotoxic actions of formosan plant drugs
Yang, L., Yen, K., Kiso, Y., et al. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90142-5 · Cited by 91 · see citing works
Herbs, Spices, and Medicinal Plants: Recent Advances in Botany, Horticulture and Pharmacology, Volume 2.
Craker, L. E., & Simon, J. E. (1987) · Bulletin of the Torrey Botanical Club · doi:10.2307/2996007 · Cited by 91 · see citing works
Folk medicine in tonga. A study on the use of herbal medicines for obstetric and gynaecological conditions and disorders
Singh, Y. N., Ikahihifo, T., Panuve, M., et al. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90060-6 · Cited by 91 · see citing works
Ethnobotanical review of medicinal plants from thai traditional books, Part I: Plants with anti-inflammatory, anti-asthmatic and antihypertensive properties
Panthong, A., Kanjanapothi, D., & Taylor, W. C. (1986) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(86)90001-2 · Cited by 86 · see citing works
An Ethnopharmacognostic Approach to the Search for Immunomodulators of Plant Origin
Labadie, R. P., van der Nat, J. M., Simons, J. M., Kroes, B. H., Kosasi, S., van den Berg, A. J. J., Hart, L. A. '., van der Sluis, W., Abeysekera, A. M., Bamunuarachchi, A., et al. (1989) · Planta Medica · doi:10.1055/s-2006-962024 · Cited by 84 · see citing works
Medico-ethno botany of Mount Abu, Rajasthan, India
Sebastian, M. K., & Bhandari, M. M. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90050-3 · Cited by 77 · see citing works
Medicinal Plants Used for the Treatment of Hepatitis in Taiwan
Lin, C., & Kan, W.-S. (1990) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x9000006x · Cited by 73 · see citing works
Titrated Extract of Centella Asiatica (TECA) in the Treatment of Venous Insufficiency of the Lower Limbs
Pointel, J. P., Boccalon, H., Cloarec, M., Ledevehat, C., & Joubert, M. (1987) · Angiology · doi:10.1177/000331978703800106 · Cited by 71 · see citing works
Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer
Hausen, B. M. (1993) · Contact Dermatitis · doi:10.1111/j.1600-0536.1993.tb03532.x · Cited by 71 · see citing works
Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid
Grimaldi, R., Ponti, F. D., D'Angelo, L., Caravaggi, M., Guidi, G., Lecchini, S., Frigo, G. M., & Crema, A. (1990) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(90)90033-p · Cited by 70 · see citing works
Spectroscopic determination of structures of triterpenoid trisaccharides from Centella asiatica
Sahu, N. P., ROY, S. K., & Mahato, S. B. (1989) · Phytochemistry · doi:10.1016/s0031-9422(00)98106-8 · Cited by 66 · see citing works
Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial
Mallol, J., BELDA, M. A., COSTA, D., et al. (1991) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.1991.tb00547.x · Cited by 66 · see citing works
Medical ethnobotany of the Marma tribe of Bangladesh
Alam, M. K. (1992) · Economic Botany · doi:10.1007/bf02866632 · Cited by 66 · see citing works
Ethnobotanical studies in nagaland. I. medicinal plants
Rao, R. R., & Jamir, N. S. (1982) · Economic Botany · doi:10.1007/bf02858714 · Cited by 64 · see citing works
Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats.
Chatterjee, T. K., Chakraborty, A., Pathak, M., & Gc, S. (1992) · PubMed · Cited by 64 · see citing works
Pharmacological evaluation of Thai medicinal plants.
Mokkhasmit, M., Ngarmwathana, W., Sawasdimongkol, K., et al. (1971) · PubMed · Cited by 63 · see citing works
Effect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures.
Tenni, R., Zanaboni, G., Agostini, M. P. D., Rossi, A., Bendotti, C., & Cetta, G. (1988) · PubMed · Cited by 61 · see citing works
Traditional phytotherapy among the sherpas of helambu, Central Nepal
Bhattarai, N. K. (1989) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(89)90076-7 · Cited by 61 · see citing works
Mono- and sesquiterpenoids from Hydrocotyle and Centella species
Asakawa, Y., Matsuda, R., & TAKEMOTO, T. (1982) · Phytochemistry · doi:10.1016/0031-9422(82)85264-3 · Cited by 58 · see citing works
Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban
Günther, B., & Wagner, H. (1996) · Phytomedicine · doi:10.1016/s0944-7113(96)80011-0 · Cited by 52 · see citing works
A psycho-neuropharmacological profile of Centella asiatica extract.
Sakina, M., & Dandiya, P. C. (1990) · Fitoterapia · Cited by 51 · see citing works
Über die antimikrobielle Wirksamkeit von Saponinen
Tschesche, R., & Wulff, G. (1965) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1965-0610 · Cited by 48 · see citing works
Improvement of Capillary Permeability in Patients with Venous Hypertension After Treatment with TTFCA
Belcaro, G. V., Grimaldi, R., & Guidi, G. (1990) · Angiology · doi:10.1177/000331979004100705 · Cited by 43 · see citing works
Traditional Medicinal Plants of New Ireland, Papua New Guinea
Holdsworth, D., Hurley, C. L., & Rayner, S. E. (1980) · Quarterly Journal of Crude Drug Research · doi:10.3109/13880208009065191 · Cited by 37 · see citing works
Folklore Medicines from Assam and Arunachal Pradesh (District Tirap)
Tiwari, K. C., Majumder, R., & Bhattacharjee, S. (1979) · Quarterly Journal of Crude Drug Research · doi:10.3109/13880207909067450 · Cited by 34 · see citing works
Clinical applications of Centella asiatica (L.) Urb.
Kartnig, T. (1988) · Europe PMC (PubMed Central) · Cited by 33 · see citing works
The morphological and pharmacological effects of asiaticoside upon skin in vitro and in vivo
Lawrence, J. C. (1967) · European Journal of Pharmacology · doi:10.1016/0014-2999(67)90104-5 · Cited by 31 · see citing works
Traditional Medicinal Plants of New Ireland, Papua New Guinea Part. II. New Hanover Island
Holdsworth, D., Pilokos, B., & Lambes, P. (1983) · International Journal of Crude Drug Research · doi:10.3109/13880208309070636 · Cited by 27 · see citing works
Reticuloses and epidermal tumors in hairless mice after topical skin applications of cantharidin and asiaticoside.
Lærum, O. D., & Iversen, O. H. (1972) · PubMed · Cited by 26 · see citing works
Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins.
Arpaia, M. R., Ferrone, R., Amitrano, M., Nappo, C., Leonardo, G., & Guercio, R. D. (1990) · PubMed · Cited by 25 · see citing works
An experimental study of the anti-HSV-II action of 500 herbal drugs.
Ms, Z. (1989) · PubMed · Cited by 25 · see citing works
Allergic contact dermatitis from a cream containing Centella asiatica extract
Izu, R., Aguirre, A., Gil, N., & Díaz-Pérez, J. L. (1992) · Contact Dermatitis · doi:10.1111/j.1600-0536.1992.tb00291.x · Cited by 25 · see citing works
Contact dermatitis due to Madecassol
Eun, H. C., & Lee, A. (1985) · Contact Dermatitis · doi:10.1111/j.1600-0536.1985.tb02584.x · Cited by 24 · see citing works
Less known uses of weeds as medicinal plants.
Tr, S. (1984) · PubMed · Cited by 24 · see citing works
Effect of terpenoids isolated from centella asiatica on granuloma tissue
Hg, V., SOUZA, N. J. D., apos, D., et al. (1990) · Cited by 22 · see citing works
Capillary Filtration and Ankle Edema in Patients with Venous Hypertension Treated with TTFCA
Belcaro, G. V., Rulo, A., & Grimaldi, R. (1990) · Angiology · doi:10.1177/000331979004100102 · Cited by 21 · see citing works
Evaluation of the healing activity of hydrocotyle tincture in the treatment of wounds
Morisset, R., Côté, N. G., Panisset, J.-C., et al. (1987) · Phytotherapy Research · doi:10.1002/ptr.2650010305 · Cited by 21 · see citing works
Centella Asiatica Triterpenic Fraction (CATTF) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome.
Montecchio, G. P., Samaden, A., Carbone, S., Vigotti, M., Siragusa, S., & Piovella, F. (1991) · PubMed · Cited by 21 · see citing works
Ethnobotanical Observations on Plants Used in Northeastern India
Saklani, A., & Jain, S. K. (1989) · International Journal of Crude Drug Research · doi:10.3109/13880208909053940 · Cited by 18 · see citing works
Anti-anxiety profile of manduk parni (Centella asiatica) in animals.
Diwan, P. V. (1991) · Fitoterapia · Cited by 18 · see citing works
A Review on Medicinal Plants
Thalluri, J. (2016) · Cited by 17 · see citing works
RETICULOENDOTHELIAL SYSTEM STIMULANTS OF BOTANICAL ORIGIN.
DiCarlo, F. J., Lj, H., Sliver, N. J., et al. (1964) · PubMed · Cited by 16 · see citing works
Rhône-Poulenc re-structures
(1995) · Additives for Polymers · doi:10.1016/0306-3747(95)90087-x · Cited by 4 · see citing works

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Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
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Diniz, L. R. L., Calado, L. L., Duarte, A. B. S., & de Sousa, D. P. (2023) · Metabolites · doi:10.3390/metabo13020276 · Cited by 160 · see citing works
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Authors: Brinkhaus, B., Lindner, M., Schuppan, D., & Hahn, E. G.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author: Brinkhaus, B.
ORCID: Brinkhaus, B.
Lindner, M.
Schuppan, D.
Venue: Phytomedicine
Publisher: Elsevier BV
Published: 2000-10
Volume: 7
Issue: 5
Pages: 427-448
ISSN: 0944-7113 (ISSN-L)
DOI: 10.1016/s0944-7113(00)80065-3
OpenAlex: W2051827697
Cited by: 525
References: 61
Citations by year: 2026: 24 · 2025: 37 · 2024: 37 · 2023: 37 · 2022: 32 · 2021: 45 · 2020: 26 · 2019: 30 · 2018: 28 · 2017: 15 · 2016: 24 · 2015: 17 · 2014: 24 · 2013: 34 · 2012: 26
FWCI: 0.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Phytomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Keywords: Centella asiatica, medicinal plants, pentacyclic triterpenes, madecassoside, asiaticoside, venous insufficiency, striae gravidarum, wound healing, traditional medicine, pharmacological activity, clinical efficacy
MeSH terms: Drugs, Chinese Herbal, Humans, Plants, Medicinal, Wound Healing, Apiaceae

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Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

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