Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels in GCF and saliva of patients with or without CP. METHODS: Electronic searches of the PubMed, Web of Science, and Scopus databases were conducted for publications up to February 2016 that investigated the levels of IL-8 detected in individuals with CP compared with health individuals. A total of 31 publications were included in the systematic review. For meta-analyses, the strength of association was calculated by pooled odds ratios with 95% confidence intervals using RevMan 5.1 software. Heterogeneity was examined using Higgins I-squared, tau-squared, and χ tests. RESULTS: In biopsies of gingival tissue of CP patients, all studies found higher IL8 mRNA levels, and the majority of studies showed higher IL-8 protein levels in this tissue of individuals with moderate to severe CP. Four studies investigating the IL-8 levels in saliva showed inconclusive results. In spite of some studies seemed to indicate higher levels of IL-8 in GCF of CP patients, the meta-analysis results showed significantly lower IL-8 levels (pg/μL) in GCF of CP patients in comparison with periodontally healthy subjects. CONCLUSIONS: We concluded that IL8 gene expression and IL-8 protein levels were higher in gingival tissues of CP patients when compared to periodontally health individuals. Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found lower levels in CP patients. There are conflicting evidences regarding IL-8 levels in saliva.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In periodontitis conditions, increased IL-8 gene expression and higher IL-8 protein levels have been observed compared to healthy subjects.
“In periodontitis conditions, increased IL-8 gene expression and higher IL-8 protein levels have been observed compared to healthy subjects”
From Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review (2023) · cites this paper as [145]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826 · see citing works
Periodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688 · see citing works
Cytokines that promote periodontal tissue destruction.
Graves, D. (2008) · The Journal of Periodontology · doi:10.1902/jop.2008.080183 · Cited by 746 · see citing works
Role of cytokines and inflammatory mediators in tissue destruction
Birkedal‐Hansen, H. (1993) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1993.tb02113.x · Cited by 618 · see citing works
The role of interleukin-8 in inflammation and mechanisms of regulation.
Bickel, M. (1993) · PubMed · Cited by 468 · see citing works
Górska, R., Gregorek, H., Kowalski, J., Laskus‐Perendyk, A., Syczewska, M., & Madalinski, K. (2003) · Journal Of Clinical Periodontology · doi:10.1046/j.0303-6979.2003.00425.x · Cited by 365 · see citing works
Salivary biomarkers of existing periodontal disease
Miller, C. S., King, C. P., Langub, M. C., Kryscio, R. J., & Thomas, M. V. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0181 · Cited by 362 · see citing works
Gamonal, J. A., Acevedo, A., Bascones, A., Jorge, O., & Silva, A. H. L. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1535 · Cited by 352 · see citing works
Levels of Interleukin‐1β and Interleukin‐8 in Gingival Crevicular Fluids in Adult Periodontitis
Tsai, C., Ho, Y. P., & Chen, C. (1995) · Journal of Periodontology · doi:10.1902/jop.1995.66.10.852 · Cited by 255 · see citing works
Effect of inflammation, smoking and stress on gingival crevicular fluid cytokine level
Giannopoulou, C., Kamma, J. J., & Mombelli, A. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.300201.x · Cited by 252 · see citing works
Teles, R., Likhari, V., Socransky, S., & Haffajee, A. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01119.x · Cited by 209 · see citing works
Goodson, J. M. (2003) · Periodontology 2000 · doi:10.1034/j.1600-0757.2003.03104.x · Cited by 204 · see citing works
Tonetti, M. S., Imboden, M. A., Gerber, L., Lang, N. P., Laissue, J. A., & Mueller, C. (1994) · Infection and Immunity · doi:10.1128/iai.62.9.4005-4014.1994 · Cited by 198 · see citing works
Tonetti, M. S., Imboden, M. A., & Lang, N. P. (1998) · Journal of Periodontology · doi:10.1902/jop.1998.69.10.1139 · Cited by 196 · see citing works
Teles, R. P., Sakellari, D., Teles, F., Konstantinidis, A., Kent, R., Socransky, S. S., & Haffajee, A. D. (2010) · Journal of Periodontology · doi:10.1902/jop.2009.090397 · Cited by 192 · see citing works
Yamazaki, K., Honda, T., Oda, T., Ueki‐Maruyama, K., Nakajima, T. E., Yoshie, H., & Seymour, G. J. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00772.x · Cited by 188 · see citing works
Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis
Tymkiw, K. D., Thunell, D. H., Johnson, G. K., Joly, S., Burnell, K. K., Cavanaugh, J. E., Brogden, K. A., & Guthmiller, J. M. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01684.x · Cited by 183 · see citing works
Lamster, I. B., Oshrain, R. L., & Gordon, J. M. (1986) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb00885.x · Cited by 177 · see citing works
Gamonal, J. A., Acevedo, A., Bascones, A., Jorge, O., & Silva, A. H. L. (2001) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2001.360309.x · Cited by 162 · see citing works
Human saliva proteome analysis and disease biomarker discovery
Hu, S., Loo, J. A., & Wong, D. T. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.4.531 · Cited by 150 · see citing works
Matsuki, Y., Yamamoto, T. S., & Hara, K. (1992) · PubMed · Cited by 136 · see citing works
Duarte, P. M., da Rocha, M., de Sampaio, E. G., Mestnik, M. J., Feres, M., Figueiredo, L. C., Bastos, M. F., & Faveri, M. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.090732 · Cited by 129 · see citing works
Ertuğrul, A. S., Sahin, H., Dikilitaş, A., Alpaslan, N., & Bozoğlan, A. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01500.x · Cited by 128 · see citing works
Venza, I., Visalli, M., Cucinotta, M. D., Grazia, G. D., Teti, D. V., & Venza, M. (2010) · Journal of Periodontology · doi:10.1902/jop.2009.090358 · Cited by 126 · see citing works
Periodontitis May Increase the Risk of Peripheral Arterial Disease
Chen, Y., Umeda, M., Nagasawa, T., Takeuchi, Y., Huang, Y., Inoue, Y., Iwai, T., Izumi, Y., & Ishikawa, I. (2007) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.08.016 · Cited by 125 · see citing works
Serum Cytokine Levels in Periodontitis Patients in Relation to the Bacterial Load
Andrukhov, O., Ulm, C., Reischl, H., Nguyen, P. Q., Matejka, M., & Rausch‐Fan, X. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100425 · Cited by 122 · see citing works
Interleukin‐1 alpha, interleukin‐8 and interferon‐alpha levels in gingival crevicular fluid
Mathur, A., Michalowicz, B. S., Castillo, M., & Aeppll, D. (1996) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1996.tb01414.x · Cited by 114 · see citing works
Salazar, M. G., Jehmlich, N., Murr, A., Dhople, V. M., Holtfreter, B., Hammer, E., Völker, U., & Kocher, T. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12130 · Cited by 108 · see citing works
Konopka, Ł., Pietrzak, A., & Brzezińska‐Błaszczyk, E. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01480.x · Cited by 98 · see citing works
Cheng, Y. L., Jordan, L., Gorugantula, L. M., Schneiderman, E. D., Chen, H., & Rees, T. D. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.130320 · Cited by 94 · see citing works
Interleukin‐8 and β‐glucuronidase in gingival crevicular fluid
Chung, R.-S., Grbic, J. T., & Lamster, I. B. (1997) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1997.tb00483.x · Cited by 87 · see citing works
Jin, L., Söder, B., & Corbet, E. F. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.6.929 · Cited by 80 · see citing works
McGee, J. M., Tucci, M. A., Edmundson, T. P., Serio, C. L., & Johnson, R. B. (1998) · Journal of Periodontology · doi:10.1902/jop.1998.69.8.865 · Cited by 77 · see citing works
César‐Neto, J. B., Duarte, P. M., Oliveira, M. C. G., Tambeli, C. H., Sallum, E. A., & Nociti, F. H. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00934.x · Cited by 76 · see citing works
Khalaf, H., Lönn, J., & Bengtsson, T. (2014) · Cytokine · doi:10.1016/j.cyto.2014.02.007 · Cited by 75 · see citing works
Ferreira, S. B., Trombone, A. P. F., Repeke, C. E. P., Cardoso, C. R. D. B., Martins, W., Santos, C. F., Trevilatto, P. C., Ávila-Campos, M. J., Campanelli, A. P., Silva, J. S., et al. (2008) · Infection and Immunity · doi:10.1128/iai.00546-08 · Cited by 74 · see citing works
Interleukin‐8 Gene Promoter Polymorphism (rs4073) May Contribute to Chronic Periodontitis
Andia, D. C., de Oliveira, N. F. P., Letra, A., Nociti, F. H., Line, S. R. P., & de Souza, A. P. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100513 · Cited by 66 · see citing works
Duarte, P. M., De Oliveira, M. C. G., Tambeli, C. H., Parada, C. A., Casati, M. Z., & Nociti, F. H. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00961.x · Cited by 66 · see citing works
Goutoudi, P., Diza, E., & Arvanitidou, M. (2011) · International Journal of Dentistry · doi:10.1155/2012/362905 · Cited by 65 · see citing works
Gürsoy, U. K., Könönen, E., & Uitto, V. J. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00453.x · Cited by 61 · see citing works
IL-8 degradation byPorphyromonas gingivalisproteases
Zhang, J., Dong, H., Kashket, S., & Duncan, M. J. (1999) · Microbial Pathogenesis · doi:10.1006/mpat.1998.0277 · Cited by 61 · see citing works
Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease
Corrêa, J. D., Madeira, M. F. M., Resende, R. G., Correia‐Silva, J. D. F., Gomez, R. S., de Souza, D. D. G., Teixeira, M. M., Queiroz‐Junior, C. M., & Silva, T. A. (2012) · Mediators of Inflammation · doi:10.1155/2012/846052 · Cited by 53 · see citing works
Salivary Proteins and Cytokines in Drug-induced Gingival Overgrowth
Rühl, S., Hamberger, S., Betz, R., Sukkar, T. Z., Schmalz, G., Seymour, R. A., Hiller, K., & Thomason, J. M. (2004) · Journal of Dental Research · doi:10.1177/154405910408300410 · Cited by 52 · see citing works
Luo, L., Xie, P., Gong, P., Tang, X., Ding, Y., & Deng, L.-X. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.03.020 · Cited by 52 · see citing works
Chapple, I., Matthews, J. B., Thorpe, G. H. G., Glenwright, H. D., Smith, J. M., & Saxby, M. S. (1993) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1993.tb02093.x · Cited by 46 · see citing works
Clinical Significance of Gingival Fluid Measurement by “Periotron”
Tsuchida, K., & Hara, K. (1981) · Journal of Periodontology · doi:10.1902/jop.1981.52.11.697 · Cited by 44 · see citing works
Protease-activated Receptor-2 (par 2 ) in Human Periodontitis
Holzhausen, M., Cortelli, J. R., da Silva, V. A., Franco, G. C. N., Cortelli, S. C., & Vergnolle, N. (2010) · Journal of Dental Research · doi:10.1177/0022034510373765 · Cited by 43 · see citing works
Relationship Between Chemokines and Dendritic Cells in Human Chronic Periodontitis
Souto, G. R., Queiroz‐Junior, C. M., Costa, F. O., & Mesquita, R. A. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.130662 · Cited by 37 · see citing works
Carcinoma cell‐derived chemokines and their presence in oral fluid
Michiels, K., Schutyser, E., Conings, R., Lenaerts, J., Put, W., Nuyts, S., Delaere, P., Jacobs, R., Struyf, S., Proost, P., et al. (2009) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2009.00644.x · Cited by 36 · see citing works
Sfakianakis, A., Barr, C. E., & Kreutzer, D. L. (2002) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2002.00024.x · Cited by 35 · see citing works
Inhibitory effects of whole and parotid saliva on immunomodulators
Wozniak, K. L., Arribas, A. R., Leigh, J. E., & Fidel, P. L. (2002) · Oral Microbiology and Immunology · doi:10.1046/j.0902-0055.2001.00101.x · Cited by 35 · see citing works
Teles, R. P., Sakellari, D., Konstantinidis, A., Socransky, S. S., & Haffajee, A. D. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080440 · Cited by 23 · see citing works
Lütfioğlu, M., Aydoğdu, A., Sakallıoğlu, E. E., Alaçam, H., & Pamuk, F. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12324 · Cited by 23 · see citing works
Guentsch, A., Pfister, W., Cachovan, G., Raschke, G. F., Kuepper, H., Schaefer, O., & Eick, S. (2013) · International Journal of Dental Hygiene · doi:10.1111/idh.12063 · Cited by 22 · see citing works
Bacterial and inflammatory behavior of implants in the early healing phase of chronic periodontitis.
Cosgarea, R., Dannewitz, B., Sculean, A., Bran, S., Rotaru, H., Băciuț, G., & Eick, S. (2012) · PubMed · Cited by 19 · see citing works
Pulikkotil, S. J., Nath, S., & Patel, R. P. (2014) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2014.44.3.126 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [50]Zhang J Dong H Kashket S IL-8 degradation by Porphyromonas gingivalis proteases. Microb Pathog 1999; 26: 275– 80. 10222212
Cited by
Sorted by citations
Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery
Wang, B., Booij-Vrieling, H. E., Bronkhorst, E. M., Shao, J., Kouwer, P. H. J., Jansen, J. A., Walboomers, X. F., & Yang, F. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.018 · Cited by 99 · see citing works
Albuquerque‐Souza, E., Balzarini, D., Ando‐Suguimoto, E. S., Ishikawa, K. H., Simionato, M. R. L., Holzhausen, M., & Mayer, M. P. A. (2018) · Journal of Periodontal Research · doi:10.1111/jre.12608 · Cited by 70 · see citing works
Rowińska, I., Szyperska-Ślaska, A., Zariczny, P., Pasławski, R., Kramkowski, K., & Kowalczyk, P. (2021) · Materials · doi:10.3390/ma14061444 · Cited by 59 · see citing works
The impact of aging on neutrophil functions and the contribution to periodontitis
Wang, Z., Saxena, A., Yan, W., Uriarte, S. M., de Siqueira, R. A. C., & Li, X. (2025) · International Journal of Oral Science · doi:10.1038/s41368-024-00332-w · Cited by 58 · see citing works
Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review
Alarcón-Sánchez, M. A., Heboyan, A., Fernandes, G. V. D. O., Castro-Alarcón, N., & Romero-Castro, N. S. (2023) · Molecules · doi:10.3390/molecules28031075 · Cited by 52 · see citing works
Martín, V., Ribeiro, I., Alves, M. M., Gonçalves, L., Almeida, A. J., Grenho, L., Fernandes, M. H., Santos, C. F., Gomes, P. S., & Bettencourt, A. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118821 · Cited by 53 · see citing works
Biomarkers of alveolar bone resorption in gingival crevicular fluid: A systematic review
Almehmadi, A. H., & Alghamdi, F. T. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.05.004 · Cited by 48 · see citing works
Riis, J. L., Ahmadi, H., Hamilton, K. R., Hand, T. A., & Granger, D. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.009 · Cited by 43 · see citing works
Huang, Y., Tseng, K.-F., Tsai, P.-H., Wang, J.-S., Lee, C.-Y., & Shen, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073641 · Cited by 40 · see citing works
Current and Potential Applications of Monoterpenes and Their Derivatives in Oral Health Care
Potocka, W., Assy, Z., Bikker, F., & Laine, M. L. (2023) · Molecules · doi:10.3390/molecules28207178 · Cited by 34 · see citing works
Kaczyński, T., Wroński, J., Głuszko, P., Kryczka, T., Miskiewicz, A., Górski, B., Radkowski, M., Strzemecki, D., Grieb, P., & Górska, R. (2019) · Central European Journal of Immunology · doi:10.5114/ceji.2019.89601 · Cited by 39 · see citing works
Costantini, E., Sinjari, B., Falasca, K., Reale, M., Caputi, S., Jagarlapoodi, S., & Murmura, G. (2021) · Mediators of Inflammation · doi:10.1155/2021/5562340 · Cited by 39 · see citing works
Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling
Zhang, Y., Zou, B., Tan, Y., Su, J., Wang, Y., Xu, J., Tao, L., Zhou, H., Liu, L., & Li, X. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.015 · Cited by 38 · see citing works
Corbi, S. C. T., de Vasconcellos, J. F., Bastos, A. D. S., Bussaneli, D. G., da Silva, B. R., dos Santos, R. A., Takahashi, C. S., Rocha, C. S., Carvalho, B. S., Maurer‐Morelli, C. V., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65042-9 · Cited by 37 · see citing works
Self-citationKang, W., Shang, L., Wang, T., Liu, H., & Ge, S. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0571 · Cited by 34 · see citing works
Oliveira, J. A., Alves, R. D. O., Nascimento, I. M., Hidalgo, M. A. R., Scarel‐Caminaga, R. M., & Pigossi, S. C. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03072-1 · Cited by 35 · see citing works
Self-citationCXCL5, CXCL8, and CXCL10 regulation by bacteria and mechanical forces in periodontium
Rath-Deschner, B., Beisel-Memmert, S., Damanaki, A., de Molon, R. S., Nokhbehsaim, M., Eick, S., Kirschneck, C., Cirelli, J. A., Deschner, J., Jäger, A., et al. (2020) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2020.151648 · Cited by 31 · see citing works
Association between Epstein-Barr virus and periodontitis: A meta-analysis
Maulani, C., Auerkari, E. I., Masulili, S. L. C., Soeroso, Y., Santoso, W. D., & Kusdhany, L. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258109 · Cited by 30 · see citing works
The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review
Khouly, I., Braun, R. S., Ordway, M., Aouizerat, B. E., Ghassib, I. H., Larsson, L., & Asa’ad, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176217 · Cited by 28 · see citing works
Ma, X., Wang, Y., Wu, H., Li, F. R., Feng, X., Xie, Y., Xie, D., Wang, W., Lo, E. C. M., & Lu, H. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00239-0 · Cited by 28 · see citing works
Therapeutic targeting of the host-microbiota-immune axis: implications for precision health
Nazir, A., Hussain, F. H. N., Hussain, T. H. N., Dweik, R. A., & Raza, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1570233 · Cited by 30 · see citing works
Update on the Role of Cytokines as Oral Biomarkers in the Diagnosis of Periodontitis.
Blanco-Pintos, T., Regueira-Iglesias, A., Balsa-Castro, C., & Tomás, I. (2022) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-96881-6_15 · Cited by 16 · see citing works
CXCL8 , MMP12 , and MMP13 are common biomarkers of periodontitis and oral squamous cell carcinoma
Chen, X., Lei, H., Cheng, Y., Fang, S., Sun, W., Zhang, X., & Jin, Z. (2022) · Oral Diseases · doi:10.1111/odi.14419 · Cited by 27 · see citing works
Behaviour of Human Oral Epithelial Cells Grown on Invisalign® SmartTrack® Material
Nemec, M., Bartholomaeus, H. M., Bertl, M. H., Behm, C., Shokoohi-Tabrizi, H. A., Jonke, E., Andrukhov, O., & Rausch‐Fan, X. (2020) · Materials · doi:10.3390/ma13235311 · Cited by 26 · see citing works
Yoshida, R. A., Gorjão, R., Mayer, M. P. A., Corazza, P. F. L., Guaré, R. D. O., Ferreira, A. C. F. M., & Santos, M. T. B. R. (2019) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2019.vol33.0033 · Cited by 25 · see citing works
Caldeira, F. I. D., Hidalgo, M. A. R., de Carli, M. L., Scarel‐Caminaga, R. M., & Pigossi, S. C. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105147 · Cited by 25 · see citing works
Self-citationda Silva, B. R., Cirelli, T., Nepomuceno, R., Theodoro, L. H., Orrico, S. R. P., Cirelli, J. A., Barros, S. P., & Scarel‐Caminaga, R. M. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.08.036 · Cited by 22 · see citing works
Self-citationBueno, M. R., Ishikawa, K., Santos, G. D. A., Ando‐Suguimoto, E. S., Shimabukuro, N., Kawamoto, D., & Mayer, M. P. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.846192 · Cited by 20 · see citing works
The Impact of Oral-Gut Inflammation in Cerebral Palsy
Ferreira, A. C. F. M., Eveloff, R. J., Freire, M., & Santos, M. T. B. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.619262 · Cited by 19 · see citing works
Salivary Bioscience, Immunity, and Inflammation
Riis, J. L., Byrne, M., Hernández, L. M., & Robles, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-35784-9_9 · Cited by 13 · see citing works
Mlachkova, A., Popova, C., & Doseva, V. (2020) · Folia Medica · doi:10.3897/folmed.62.e47722 · Cited by 18 · see citing works
Holm, W. V., Verspecht, T., Carvalho, R., Bernaerts, K., Boon, N., Zayed, N., & Teughels, W. (2022) · Molecular Oral Microbiology · doi:10.1111/omi.12386 · Cited by 19 · see citing works
ARROYO, E. A., Alves, M. G. O., Chamorro-Petronacci, C. M., Marichalar‐Mendía, X., Bravo, S. B., Blanco, J., & Pérez‐Sayáns, M. (2022) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2022.12.004 · Cited by 17 · see citing works
An, N., Holl, J., Wang, X., Rausch, M. A., Andrukhov, O., & Rausch‐Fan, X. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020483 · Cited by 19 · see citing works
Salhi, L., Rijkschroeff, P., Hede, D. V., Laine, M. L., Teughels, W., Sakalihasan, N., & Lambert, F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.766462 · Cited by 16 · see citing works
Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes
Belkina, A. C., Azer, M., Lee, J. J., Elgaali, H., Pihl, R. M. F., Cleveland, M., Carr, J., Kim, S. W., Habib, C., Hastürk, H., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520912188 · Cited by 16 · see citing works
Rakhimova, O., Schmidt, A., Landström, M., Johansson, A. S., Kelk, P., & Vestman, N. R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.620801 · Cited by 16 · see citing works
Merle, C. L., Richter, L., Challakh, N., Haak, R., Schmalz, G., Needleman, I. G., Rüdrich, P., Wolfarth, B., Ziebolz, D., & Wüstenfeld, J. C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175161 · Cited by 14 · see citing works
Mercer, S. D., Doherty, C., Singh, G., Willmott, T., Cheesapcharoen, T., Teanpaisan, R., O’Neill, C. A., Ledder, R. G., & McBain, A. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-86914-y · Cited by 14 · see citing works
Zhang, F., Özdemir, B., Nguyen, P. Q., Andrukhov, O., & Rausch‐Fan, X. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01087-6 · Cited by 14 · see citing works
Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndrome
Nibali, L., Stephen, A. S., Hagi‐Pavli, E., Allaker, R. P., Pino, A. D., Terranova, V., Pisano, M., Marca, S. D., Ferrara, V., Scicali, R., et al. (2022) · Journal of Dentistry · doi:10.1016/j.jdent.2022.104065 · Cited by 13 · see citing works
Salivary and gingival CXCL8 correlation with periodontal status, periodontal pathogens, and smoking
Frasheri, I., Heym, R., Ern, C., Summer, B., Hennessen, T. G., Högg, C., Reichl, F., & Folwaczny, M. (2021) · Oral Diseases · doi:10.1111/odi.13994 · Cited by 12 · see citing works
Ho, M., Hastürk, H., Young, D. F., & Xie, H. (2020) · Molecular Oral Microbiology · doi:10.1111/omi.12305 · Cited by 12 · see citing works
Albuquerque‐Souza, E., Ishikawa, K. H., Amado, P. P. P., Nicoli, J. R., Holzhausen, M., & Mayer, M. P. A. (2021) · Anaerobe · doi:10.1016/j.anaerobe.2021.102458 · Cited by 11 · see citing works
Ha, Y.-E., So, Y. J., Im, J., Yun, C., Park, J., & Han, S. H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110161 · Cited by 10 · see citing works
Correlation of serum vitamin D and IL-8 to stages of periodontitis: a case-control analysis
Saleh, W., Ata, F., Nosser, N. A., & Mowafey, B. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-06025-2 · Cited by 10 · see citing works
Hong, Q., Ren, Y., Tang, X., Mao, B., Zhang, Q., Zhao, J., Cui, S., & Liu, Z. (2025) · Microorganisms · doi:10.3390/microorganisms13071701 · Cited by 10 · see citing works
Chang, A. M., Bamashmous, S., Darveau, R. P., & Rajapakse, S. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2850-8 · Cited by 10 · see citing works
Kawasaki, H., & Amano, H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12220 · Cited by 10 · see citing works
Ng, M. Y., Lin, T., Chen, S.-H., Liao, Y., Liu, C., & Yu, C. (2024) · Journal of Dental Sciences · doi:10.1016/j.jds.2023.12.011 · Cited by 9 · see citing works
Bumm, C. V., Schwendicke, F., Heck, K., Frasheri, I., Summer, B., Ern, C., Heym, R., Werner, N., & Folwaczny, M. (2024) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.14055 · Cited by 9 · see citing works
Palmitic acid induces GSDMD ‐mediated pyroptosis in periodontal ligament cells via the NF‐κB pathway
Sun, B., Chen, M., Zhang, W., Zhao, B., Zhang, M., Han, X., Yu, L., & Liu, Y. (2023) · Oral Diseases · doi:10.1111/odi.14648 · Cited by 9 · see citing works
Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens
Serrage, H. J., Cooper, P. R., Palin, W. M., Horstman, P., Hadis, M. A., & Milward, M. R. (2021) · Lasers in Medical Science · doi:10.1007/s10103-021-03331-z · Cited by 9 · see citing works
da Rocha, A. C. S. D., Orlandini, R. K., Motta, A. C. F., Pinheiro, J. B., Silva, G. A. E., Oliveira, V. D. C., & Lourenço, A. G. (2024) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2024.1369186 · Cited by 8 · see citing works
Anti-inflammatory effects of manuka honey on salivary cytokines (clinical study)
Al-Kubaisi, M. W., Al-Ghurabi, B. H., Al-Kubaisy, W., & Abdullah, N. N. (2023) · Journal of Baghdad College of Dentistry · doi:10.26477/jbcd.v35i1.3310 · Cited by 8 · see citing works
Galli, C., Sala, R., Colangelo, M. T., & Guizzardi, S. (2019) · Publications · doi:10.3390/publications7040067 · Cited by 7 · see citing works
Boric Acid Reverses Nicotine-Induced Cytokine Expressions of Human Gingival Fibroblasts
Bozkurt, Ş. B., Nielsen, F. H., & Hakki, S. S. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03243-1 · Cited by 7 · see citing works
Im, J., Baik, J. E., Lee, D., Kum, K., Yun, C., Park, O., & Han, S. H. (2020) · Molecular Oral Microbiology · doi:10.1111/omi.12287 · Cited by 7 · see citing works
Effects of ginger (Zingiber officinale) on gingival fibroblasts: An in vitro study
Al‐Shibani, N., Al‐Kattan, R., Alssum, L. R., & Allam, E. (2022) · Clinical and Experimental Dental Research · doi:10.1002/cre2.575 · Cited by 7 · see citing works
Maltz, M. A., Melchiorre, C. K., Herbst, K. W., Hogan, A. H., Dibble, K., O’Sullivan, B., Graf, J., Jadhav, A., Lawrence, D. A., Lee, W. T., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1066391 · Cited by 7 · see citing works
Li, Y., Feng, G., Deng, Y., & Song, J. (2018) · Disease Markers · doi:10.1155/2018/2645963 · Cited by 7 · see citing works
Habibe, C., Yoshida, R., Gorjão, R., de Gutierrez, G. M., Heller, D., Birbrair, A., & Santos, M. T. B. R. (2020) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.56336 · Cited by 7 · see citing works
Stanton, K. A., & McCracken, B. A. (2021) · Clinical and Experimental Dental Research · doi:10.1002/cre2.437 · Cited by 7 · see citing works
Kang, B., Hwang, J., & Choi, H. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13291 · Cited by 7 · see citing works
Hosseini, S., Diegelmann, J., Folwaczny, M., Frasheri, I., Wichelhaus, A., Sabbagh, H., Seidel, C., Baumert, U., & Ranković, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413513 · Cited by 8 · see citing works
Hosseini, S., Diegelmann, J., Folwaczny, M., Sabbagh, H., Otto, S., Kakoschke, T. K., Wichelhaus, A., Baumert, U., & Ranković, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413525 · Cited by 7 · see citing works
Rojas, A. P., Desta, H. T., & Bianchi, M. R. (2024) · Journal of Current Research in Oral Surgery · doi:10.51847/yn2dt0ss3m · Cited by 6 · see citing works
Pimentel, S. P., Ribeiro, F. V., Casarin, R. C. V., Cirano, F. R., Luchesi, V. H., Pecorari, V. G. A., & Casati, M. Z. (2019) · Clinical Oral Implants Research · doi:10.1111/clr.13405 · Cited by 6 · see citing works
Mehar, R., Swarnakar, S., Lakkakula, S., Verma, H. K., & Bhaskar, L. V. (2021) · Journal of Oral Biosciences · doi:10.1016/j.job.2021.08.003 · Cited by 6 · see citing works
Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees
Raindi, D. S., Rees, J., Hirschfeld, J., Wright, H. J., Dobbs, P., Moittié, S., White, K., Stahl, W., Martin, M. W. S., Redrobe, S. P., et al. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105342 · Cited by 6 · see citing works
Stähli, A., Scherler, C., Zappalà, G., Sculean, A., & Eick, S. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.960732 · Cited by 6 · see citing works
Porphyromonas gingivalis affects neutrophil pro-inflammatory activities
Zimny, A., Płonczyńska, A., Jakubowski, W., Zubrzycka, N., Potempa, J., & Sochalska, M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1419651 · Cited by 5 · see citing works
Kido, R., Hiroshima, Y., Kido, J., Bando, M., Yoshida, K., Inagaki, Y., & Yumoto, H. (2025) · Journal of Oral Biosciences · doi:10.1016/j.job.2025.100624 · Cited by 5 · see citing works
Sete, M. R. C., Carlos, J. C., de Mello‐Neto, J. M., Lira‐Junior, R., Brito, F., Boström, E. A., Sztajnbok, F., & Figueredo, C. M. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12924 · Cited by 5 · see citing works
Tian, Z., Zhao, Z., Rausch, M. A., Behm, C., Tur, D., Shokoohi-Tabrizi, H. A., Andrukhov, O., & Rausch‐Fan, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020672 · Cited by 5 · see citing works
Kasnak, G., Yılmaz, M., Ünsal, R. B. K., POLAT, N. G., & Fıratlı, E. (2021) · Pathogens · doi:10.3390/pathogens10101260 · Cited by 5 · see citing works
Enamel Matrix Derivative Suppresses Chemokine Expression in Oral Epithelial Cells
Panahipour, L., Botta, S., Abbasabadi, A. O., Afradi, Z., & Gruber, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813991 · Cited by 5 · see citing works
Biomarkers for Periodontal Diseases
Buduneli, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-37317-7_5 · Cited by 4 · see citing works
Abood, F. R., & Aldhaher, Z. A. (2023) · Dental Hypotheses · doi:10.4103/denthyp.denthyp_63_23 · Cited by 4 · see citing works
Platelet-Rich Fibrin Increases CXCL8 Expression in Gingival Fibroblasts
Imani, A., Panahipour, L., Sanches, N. D. S., Wang, L., & Gruber, R. (2024) · Biomedicines · doi:10.3390/biomedicines12061326 · Cited by 4 · see citing works
Effect of type 1 diabetes on the inflammatory response in periodontal disease
Mendes-Frias, A., da Costa, A. V. D. V., Salazar, F., Braga, A., Silvestre, R., & Relvas, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683219 · Cited by 3 · see citing works
Correlation of clinical profile toward oral manifestations of HIV/AIDS patients
Apriasari, M. L., Aprilyani, N., Carabelly, A. N., & Utami, J. P. (2021) · Padjadjaran Journal of Dentistry · doi:10.24198/pjd.vol33no1.26025 · Cited by 3 · see citing works
Hashai, K., Chapple, I., Shapira, L., Assadi, W., Dadon, S., & Polak, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.847372 · Cited by 3 · see citing works
Dental Amalgam and Oral Biological Responses: A Narrative Review of Current Evidence
Mehedinti, R.-C., Satala, C.-B., Earar, K., Matei, M. N., Popa, G. V., Stefanescu, A., Covaci, A. M., Petrescu, R., Petcu, C. M., & Tutunaru, D. (2026) · Dentistry Journal · doi:10.3390/dj14030188 · Cited by 2 · see citing works
Efficacy of Curcumin Mouth Wash on Gingival Inflammation in Patients with Chronic Gingivitis
Mohammad, C. (2022) · Sulaimani dental journal · doi:10.17656/sdj-10143 · Cited by 2 · see citing works
Enioutina, E. Y., Keddington, R. J., Hauck, K. G., Chavez, A., Clifford, J. J., Cao, T., Smith, B., Job, K. M., & Balch, A. H. (2024) · Microorganisms · doi:10.3390/microorganisms12091821 · Cited by 2 · see citing works
Brain Injury and Neuroinflammation of the Gut-Brain Axis in Subjects with Cerebral Palsy
Ferreira, A. C. F. M., Freire, M., Siqueira, V. L., Ferreira, C. D. A., & Santos, M. T. B. R. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95763 · Cited by 2 · see citing works
Analysis of Periodontitis Biomarker Expression in Gingival Crevicular Fluids
Hwang, Y. S. (2021) · Journal of dental hygiene science · doi:10.17135/jdhs.2021.21.1.45 · Cited by 2 · see citing works
The ATC/TTC haplotype in the Interleukin 8 gene in response to Gram-negative bacteria: A pilot study
Pigossi, S. C., Anovazzi, G., Finoti, L. S., de Medeiros, M. C., Souza-Moreira, T. M., Mayer, M. P. A., Zanelli, C. F., Valentini, S. R., Rossa, C., & Scarel‐Caminaga, R. M. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104508 · Cited by 2 · see citing works
Self-citationAdamov, A., Bolyarova, T., Stanimirov, P., Aleksiev, E., Kandilarova, S. M., Miteva, M., Yankova, P. S., Ishkitiev, N., & Mihaylova, Z. (2024) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2024.2423777 · Cited by 1 · see citing works
Beneficial effects of non-invasive physical plasma on human periodontal ligament cells in vitro
Eggers, B., Seher, L., Marciniak, J., Pauck, T., Deschner, J., Eick, S., Stope, M. B., Kramer, F., Küchler, É. C., Kirschneck, C., et al. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1443368 · Cited by 1 · see citing works
Gutierrez, L. S., Zandim‐Barcelos, D. L., Eick, S., Lopes, M. E. S., Cirelli, J. A., Nogueira, A. V. B., & Deschner, J. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-06043-0 · Cited by 2 · see citing works
Morsy, D., Shaker, O. G., & Elkhodary, S. (2024) · Australian Endodontic Journal · doi:10.1111/aej.12914 · Cited by 1 · see citing works
Gottschalk, E. C., Chabanovska, O., Vasudevan, P., Barrantes, I., Kreikemeyer, B., Bergmann‐Ewert, W., Engelmann, R., Müller‐Hilke, B., & Lang, H. (2026) · Scientific Reports · doi:10.1038/s41598-026-37044-6 · Cited by 1 · see citing works
Lu, T., Zhu, J., Yang, S., Shen, Z., & Zhong, L. (2023) · PubMed Central · doi:10.7518/hxkq.2023.2022409 · Cited by 1 · see citing works
Rady, D., Moshy, S. E., Abbass, M. M. S., Sadek, K. M., El‐Rashidy, A. A., Radwan, I. A., & El‐Sayed, K. M. F. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_51-1 · Cited by 1 · see citing works
The role of interleukin-8 in the development and clinical progression of chronic periapical lesions
Popović, J. Z., Cvetković, T., Džopalić, T., Mitić, A., Nikolić, M., Barac, R. G., Stošić, N., & Stanković, A. (2023) · AFMN Biomedicine · doi:10.5937/afmnai41-48765 · Cited by 1 · see citing works
Al-Mufti, S. M. T., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2024) · Journal of Baghdad College of Dentistry · doi:10.26477/jbcd.v36i4.3821 · Cited by 1 · see citing works
Parakaw, T., Srihirun, S., Sibmooh, N., Ruangsawasdi, N., Khemawoot, P., & Vivithanaporn, P. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1583865 · Cited by 1 · see citing works
Li, Y., Hu, B., Feng, G., Chen, Q., Zhu, M., Ying, S., & Song, J. (2019) · Annals of Human Genetics · doi:10.1111/ahg.12321 · Cited by 1 · see citing works
- Authors
- Finoti, L. S., Nepomuceno, R., Pigossi, S. C., Corbi, S. C., Secolin, R., & Scarel-Caminaga, R. M.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Venue
- Medicine
- Published
- 2017-06
- Volume
- 96
- Issue
- 22
- Pages
- e6932
- ISSN
- 0025-7974 (ISSN-L)
- PMC
- PMC5459707
- OpenAlex
- W2617814315
- Cited by
- 119
- References
- 56
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 15 · 2021: 22 · 2020: 16 · 2019: 9 · 2018: 5
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nd
- Locations
- Medicine (publishedVersion, cc-by-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nd)
- PubMed Central (publishedVersion, cc-by-nd)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- interleukin-8, chronic periodontitis, gingival crevicular fluid, saliva, gingiva, IL-8 mRNA expression, periodontal biomarkers
- MeSH terms
- Humans, Biomarkers, Interleukin-8, Chronic Periodontitis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review