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Cited by 66Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsAdipokines, Inflammation, and Metabolic Diseases

Overexpression of interleukin‐1β and interleukin‐6 may play an important role in periodontal breakdown in type 2 diabetic patients

Duarte, P. M., De Oliveira, M. C. G., Tambeli, C. H., Parada, C. A., Casati, M. Z., Nociti, F. H.·2007·Journal of Periodontal Research
DOI 10.1111/j.1600-0765.2006.00961.x
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Abstract

Background and Objective: This study evaluated whether the biochemical changes associated with type 2 diabetes modulate the expression of interleukin‐1β, interleukin‐6, interleukin‐8, and interferon‐γ in sites with chronic periodontitis. Material and Methods: Biopsies were harvested and divided into three groups: group 1, systemically and periodontally healthy subjects (n = 10); group 2, systemically healthy subjects with moderate‐to‐severe chronic periodontitis (probing depth > 6 mm) (n = 20); and group 3, type 2 diabetic subjects with periodontitis (n = 20). Cytokine levels were assessed in the gingival tissues by enzyme‐linked immunosorbent assay analysis. Results: Data analysis demonstrated that the interleukin‐1β, interleukin‐6, interleukin‐8, and interferon‐γ levels were higher in the presence of periodontal inflammation than in the absence of inflammation, regardless of systemic status. The interleukin‐1β and interleukin‐6 levels were higher in diabetic subjects (group 3) than in systemically healthy patients with comparable types of periodontitis (group 2). No difference was observed for the interleukin‐8 and interferon‐γ levels between groups 2 and 3. Conclusion: Within the limits of this study, it was concluded that type 2 diabetes was associated with increased expression of interleukin‐1β and interleukin‐6 in periodontally inflamed tissues of diabetic patients, relative to nondiabetic subjects, and that such overexpression may be involved in the mechanisms by which type 2 diabetes enhances periodontal destruction.

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  • Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro-inflammatory molecules.

    “Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro‐inflammatory molecules.216, 217, 218”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [218]

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Authors
Duarte, P. M., De Oliveira, M. C. G., Tambeli, C. H., Parada, C. A., Casati, M. Z., & Nociti, F. H.
Affiliations
  • Guarulhos University (BR)
  • Universidade de São Paulo (BR)
  • Universidade Estadual de Campinas (UNICAMP) (BR)
Corresponding author
Nociti, F. H.
ORCID
Venue
Journal of Periodontal Research
Publisher
Wiley
Published
2007-03-30
Volume
42
Issue
4
Pages
377-381
ISSN
  • 0022-3484 (ISSN-L)
  • 1600-0765
DOI
10.1111/j.1600-0765.2006.00961.x
OpenAlex
W2033807017
Cited by
66
References
31
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 3 · 2013: 8 · 2012: 5
FWCI
4.47
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Periodontal Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
type 2 diabetes, chronic periodontitis, IL-1β, interleukin-6, interleukin-8, interferon-gamma, gingivitis, periodontal tissue destruction, cytokine expression, diabetic periodontitis
MeSH terms
Adult, Chronic Disease, Dental Plaque, Diabetes Mellitus, Type 2, Enzyme-Linked Immunosorbent Assay, Female, Gingiva, Humans, Interferon-gamma, Male, Periodontal Diseases, Periodontal Index, Interleukin-6, Interleukin-8, Interleukin-1beta

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