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Cited by 44Hormonal and reproductive studiesBlood Pressure and Hypertension StudiesSperm and Testicular Function

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Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone–binding globulin, and hypertension

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Yang, Qingtao, Li, Zhenjie, Li, Wencai, Lu, Liang, Wu, Haoqiang, Zhuang, Yiyi, Wu, Kusheng, Sui, Xuxia·2019·Medicine
DOI 10.1097/md.0000000000015628PMC PMC6531235
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Abstract

Low testosterone has been inversely associated with hypertension. Our objective was to determine the associations between total testosterone (TT), free testosterone (FT), bioavailable testosterone (BioT), sex hormone–binding globulin (SHBG), and hypertension. Two hundred fifty-three men were enrolled in this study. TT and SHBG were measured by chemiluminescent immunoassay, and FT and BioT were calculated. Hypertension was defined as systolic blood pressure (SBP) ≥140 mm Hg and/or diastolic blood pressure (DBP) ≥90 mm Hg. Our results showed that hypertensive men had higher SHBG levels, and lower FT and BioT, compared to normotensive men. FT and BioT were inversely associated with SBP and DBP after adjusting for covariates (age, smoking, alcohol consumption, and physical activity). Furthermore, there was a significant decrease in the odds ratios for hypertension in the third and fourth quartiles of BioT and FT, compared to the lowest quartile before and after adjusting for covariates. In contrast, the OR for hypertension in the third quartile of SHBG was lower than the highest quartile. Our data show that FT and BioT are inversely correlated with SBP, DBP, and hypertension in men.

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Figure 1 Shown is the cubic spline regression plot of the associations between TT (A), FT (B), BioT (C), and SBP adjusted for age, smoking, alcohol consumption, and physical activity. Predicted values are shown as a solid line, and 95% CI is shown as a black area. BioT = bioavailable, testosterone, CI = confidence interval, FT = free testosterone, SBP = systolic blood pressure, TT = total testosterone.
Figure 1 Shown is the cubic spline regression plot of the associations between TT (A), FT (B), BioT (C), and SBP adjusted for age, smoking, alcohol consumption, and physical activity. Predicted values are shown as a solid line, and 95% CI is shown as a black area. BioT = bioavailable, testosterone, CI = confidence interval, FT = free testosterone, SBP = systolic blood pressure, TT = total testosterone.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Yang, Q., Li, Z., Li, W., Lu, L., Wu, H., Zhuang, Y., Wu, K., & Sui, X.
Affiliations
  • Second Affiliated Hospital of Shantou University Medical College (CN)
  • 2012 Grade, Students of Seven-Year Clinical Medicine
  • 2013 Grade, Students of Five-Year Clinical Medicine
  • Department of Preventive Medicine
  • Shantou University Medical College (CN)
Corresponding author
  • Wu, Kusheng
  • Sui, Xuxia
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-05
Volume
98
Issue
20
Pages
e15628
ISSN
  • 0025-7974 (ISSN-L)
  • 1536-5964
DOI
10.1097/md.0000000000015628
PMC
PMC6531235
OpenAlex
W2946815958
Cited by
44
References
0
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 1
FWCI
4.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
testosterone, free testosterone, bioavailable testosterone, sex hormone-binding globulin, hypertension, systolic blood pressure, diastolic blood pressure, men, androgen deficiency
MeSH terms
Adult, Blood Pressure, Cross-Sectional Studies, Humans, Hypertension, Male, Middle Aged, Risk Factors, Serum Albumin, Sex Hormone-Binding Globulin, Testosterone, Odds Ratio

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