Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study
Open accessAbstract
Thyroid function may alter carbohydrate metabolism via influence of insulin, which may in terms of derangement of thyroid function and insulin function result in the development of type 2 diabetes mellitus (T2D). We investigated the association of thyroid disorders with T2D by a cohort study of the Taiwan nationwide health insurance database.A sub-dataset of the National Health Insurance Research Database (NHIRD) was used in this study. The thyroid disease (both hyper- and hypo-thyroidism) group was chosen from patients older than 18 years and newly diagnosed between 2000 and 2012. The control group consisted of randomly selected patients who never been diagnosed with thyroid disease and 4-fold size frequency matched with the thyroid disease group. The event of this cohort was T2D (ICD-9-CM 250.x1, 250.x2). Primary analysis was performed by comparing the thyroid disease group to the control group and the second analysis was performed by comparing the hyperthyroidism subgroup, hypothyroidism subgroup, and control group.The occurrence of T2D in the thyroid disease group was higher than the control group with hazard ratio (HR) of 1.23 [95% confidence interval (CI) = 1.16-1.31]. Both hyperthyroidism and hypothyroidism were significantly higher than control. Significantly higher HR was also seen in female patients, age category of 18 to 39-year-old (y/o) and 40 to 64 y/o subgroups. Higher occurrence of T2D was also seen in thyroid disease patients without comorbidity than in the control group with HR of 1.47 (95% CI = 1.34-1.60). The highest HR was found in the half-year follow-up.There was a relatively high risk of T2D development in patients with thyroid dysfunctions, especially in the period of 0.5 to 1 year after presentation of thyroid dysfunctions. The results suggest performing blood sugar tests in patients with thyroid diseases for early detection and treatment of T2D.
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A nation-wide cohort study reported that the occurrence rate of T2DM in hyperthyroid patients decreased after thyroid treatment.
“This is in line with the result from a nation-wide cohort study reporting the occurrence rate of T2DM in hyperthyroid patients decreased after thyroid treatment (69).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [69]
The Discussion (page not supplied) reports that T2D occurrence in patients with thyroid dysfunction decreased after an early peak, including a peak at one year for hyperthyroidism. It only suggests that treatment possibly contributed to the decrease; it does not establish that the decrease occurred after thyroid treatment. (LLM, conf=0.86)
Experimental — accuracy not yet measuredTreatment of thyroid dysfunctions can reduce the manifestation of T2DM.
“A nation-wide cohort study shows that the treatment of thyroid dysfunctions can reduce the manifestation of T2DM (69).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [69]
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- Authors
- Chen, R.-H., Chen, H.-Y., Man, K.-M., Chen, S.-J., Chen, W., Liu, P.-L., Chen, Y.-H., & Chen, W.-C.
- Affiliations
- China Medical University Hospital (TW)
- China Medical University (TW)
- Taichung Veterans General Hospital (TW)
- Kaohsiung Medical University (TW)
- Asia University (TW)
- Corresponding author
- Chen, Weishan
- Chen, Yung-Hsiang
- Chen, Wen-Chi
- Venue
- Medicine
- Published
- 2019-05
- Volume
- 98
- Issue
- 20
- Pages
- e15631
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC6531080
- OpenAlex
- W2946205931
- Cited by
- 59
- References
- 34
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 1
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Academia Sinica (BM10701010021, MOST 106-2321-B-039-005, MOHW107-TDU-B-212-123004)
- China Medical University Hospital (MOST 106-2321-B-039-005, (BM10701010021), MOHW107‐TDU‐B‐212‐123004)
- China Medical University (BM10701010021, MOST 107-2320-B-039-034, MOST 107-2314-B-039-036, DMR-108-081, MOHW107-TDU-B-212-123004)
- Division of Materials Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- thyroid dysfunction, type 2 diabetes, hyperthyroidism, hypothyroidism, insulin resistance, carbohydrate metabolism, diabetes risk, comorbidities
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, National Health Programs, Obesity, Risk Factors, Sex Factors, Taiwan, Thyroid Function Tests, Cohort Studies, Comorbidity, Proportional Hazards Models, Dyslipidemias, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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