Comparing hybrid problem-based and lecture learning (PBL + LBL) with LBL pedagogy on clinical curriculum learning for medical students in China: a meta-analysis of randomized controlled trials
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Background: Problem-based learning (PBL) combined lecture based learning (LBL) has been a trend adopted as a new medical pedagogical approach in Chinese medical teaching. This study aims to evaluate the impacts of hybrid PBL and LBL pedagogy compared with LBL teaching method on the learning achievements of clinical curriculum for Chinese medicine students. Methods: Randomized controlled trials (RCTs) were identified through a systematic literature search of electronic databases and article references up to June 2019. PubMed, EBSCO, Web of Science, Cochrane Library, Wanfang Database, CNKI, and China Biology Medicine database (CBM) were searched. End points included knowledge scores, skill scores, medical writing scores, comprehensive ability scores and teaching satisfaction. Results: Totally 20 randomized controlled studies were finally included and all Chinese literatures, involving 1817 patients. Compared with traditional LBL pedagogy, hybrid PBL and LBL pedagogy significantly increased the clinical theoretical knowledge assessment score (RR = 4.84, 95% CI: 2.92∼6.76, P < .00001), clinical skills assessment score (RR = 1.60, 95% CI: 1.39∼1.81, P < .00001), comprehensive ability score (RR = 9.13, 95% CI: 8.42∼9.84, P < .00001) and teaching satisfaction (RR = 2.58, 95% CI: 1.84∼3.62, P < .00001), The meta-regression results showed that expertise-level of students and course type were the factors that caused heterogeneity. Conclusions: Hybrid PBL and LBL pedagogy integrates the advantages of conventional teaching methods and novel teaching methods, remarkably improves the teaching efficacy, demonstrates easy acceptance by students, and meets the demand of modern medical education, so it is an effective approach to cultivate the medical talents with an ability of innovative thinking and can be advocated and popularized as a teaching means.
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The four systematic reviews and meta-analysis included in this scoping review, all carried out in China, found that PBL was more effective than lecture-based learning in improving knowledge and other skills (clinical, problem-solving, self-learning and collaborative).
“the four systematic reviews and meta-analysis included in this scoping review, all carried out in China, found that PBL was more effective than lecture-based learning in improving knowledge and other skills (clinical, problem-solving, self-learning and collaborative) [40, 51, 53, 58].”
From Effectiveness of problem-based learning methodology in undergraduate medical education: a scoping review (2022) · cites this paper as [58]
The four meta-analysis included in this review show results clearly favorable to PBL methodology in terms of knowledge, clinical skills, problem-solving, self-learning and satisfaction.
“the four meta-analysis included in this review, which included a high number of participants, show results that are clearly favorable to the PBL methodology in terms of knowledge, clinical skills, problem-solving, self-learning and satisfaction [40, 51, 53, 58].”
From Effectiveness of problem-based learning methodology in undergraduate medical education: a scoping review (2022) · cites this paper as [58]
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Cites
General competencies of problem‐based learning (PBL) and non‐PBL graduates
Prince, K. J. A. H., van Eijs, P., Boshuizen, H. P. A., van der Vleuten, C. P. M., & Scherpbier, A. J. J. A. (2005) · Medical Education · doi:10.1111/j.1365-2929.2005.02107.x · Cited by 169 · see citing works
Cohen‐Schotanus, J., Muijtjens, A. M. M., Schönrock-Adema, J., Geertsma, J., & van der Vleuten, C. P. M. (2008) · Medical Education · doi:10.1111/j.1365-2923.2007.02959.x · Cited by 84 · see citing works
Zhang, S., Xu, J., Wang, H., Zhang, D., Zhang, Q., & Zou, L. (2018) · Medicine · doi:10.1097/md.0000000000010069 · Cited by 48 · see citing works
Ma, Y., & Lu, X. (2019) · Medicine · doi:10.1097/md.0000000000014052 · Cited by 43 · see citing works
A descriptive study of medical educators' views of problem-based learning
Tavakol, M., Dennick, R., & Tavakol, S. (2009) · BMC Medical Education · doi:10.1186/1472-6920-9-66 · Cited by 27 · see citing works
Flagged first, then by citations
Research works printed but not linked: 20
- [3]Wang LQ Shi XB Ding YL PBL+LBL double-track practice in gynaecology and obstetrics teaching (in Chinese). Res Med Educ 2006; 10: 940– 1.
- [4]Zhang GW Jin J Zhou J Appliration of PBL+LBL double-track for practice of 8-year program medical students in hepato·biliary surgery department (in Chinese). J Shanxi Med Univ 2010; 12: 301– 3.
- [5]Jin J Zhang GW Application of PBL+LBL teaching methods to eightyears medical students in gynaecology and obstetrics clinic teaching (in Chinese). Basic Med Educ 2011; 13: 185– 7.
- [6]Wang Y Jiang X Appliration of PBL+LBL teaching method in the practice course of hepato-biliary surgery (in Chinese). Chin Higher Med Educ 2011; 12: 108– 9.
- [7]Wang J Li XM Tan XS The application of PBL-LBL double-track model in gynecology and obstetrics teaching (in Chinese). Guide Chin Med 2011; 22: 19– 20.
- [8]Zhang GW Application of double-track method for practice of forgein students in hepato biliary surgery department (in Chinese). Basic Med Educ 2011; 13: 477– 9.
- [9]Han Y Li XF Huang LJ The effect of double-track teaching method in the study of thoracic surgery clinical teaching (in Chinese). Prog Mod Biomed 2012; 28: 5594– 7.
- [10]Wang ZY Qiu HF Dong DQ Exploration and practice of PBL + LBLdouble-track mode in the teaching of dermatology and venerology (in Chinese). Clin Med Eng 2012; 12: 2266– 7.
- [11]Zhou Y Tang P Ming J Application of PBL+LBL in breast surgery clinical probation (in Chinese). Northwest Med Educ 2012; 5: 1044– 6.
- [12]Yu HB Application of combination of LBL and PBL teaching method in clinical practice of infectious diseases (in Chinese). Res Teach 2013; 27: 141– 2.
- [13]Ni YF Yang RX Wang J Application of problem-based learning combined with lecture-based learning in thoracic surgical clinical education (in Chinese). Basic Med Educ 2014; 8: 639– 41.
- [14]Wu X Zhang HJ Li XF Application of PBL combined with LBL in the teaching of clinical training for vascular surgery (in Chinese). Prog Mod Biomed 2014; 26: 5167– 9.
- [15]Qu SQ Shao QL Lv Y The application of problem-based learning method combined with lecture based learning in the pediatric clinical practic (in Chinese). Chin Foreign Med Res 2015; 6: 153– 4.
- [16]Wu H Sun X Shi RL Effect of PBL + LBL teaching method in the course of general practice introduction (in Chinese). Chin Gen Pract 2015; 10: 1176– 80.
- [17]Zhu H Xue H Xu L Effect research on problem based learning united lecture based learning teaching method in clinical cardiovascular medicine (in Chinese). Chin Mod Med 2015; 30: 148– 50.
- [18]Feng Y Zhou JH Jiang Y Combined application effect of PBL teaching method and LBL teaching method in internal medicine teaching (in Chinese). Chin Contin Med Educ 2016; 26: 7– 9.
- [19]Gao P Tang G Xiao H Application of problem based learning (PBL) combined with lecture based learning (LBL) teaching methods in the teaching of gerontology (in Chinese). Prog Mod Biomed 2016; 16: 3168– 71.
- [20]Niu J Application of PBL +LBL in clinical practice of inguinal hernia disease for international students (in Chinese). Chin Contin Med Educ 2016; 8: 8– 10.
- [21]Huang JJ He XJ Bai WW Application of lecture based learning plus problem based learning method in instruction of cardiac physical examination in clinical diagnostics (in Chinese). Chin Heart J 2017; 30: 248– 50.
- [22]Qian A Application of Combination of PBL and LBL in Clinical Practice Teaching of Vascular Surgery (in Chinese). China Contin Med Educ 2017; 9: 28– 9.
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Trullàs, J. C., Blay, C., Sarri, E., & Pujol, R. (2022) · BMC Medical Education · doi:10.1186/s12909-022-03154-8 · Cited by 473 · see citing works
Outcomes of problem-based learning in nurse education: A systematic review and meta-analysis.
Sharma, S., Saragih, I. D., Tarihoran, E., & Chou, F.-H. (2022) · Nurse Education Today · doi:10.1016/j.nedt.2022.105631 · Cited by 68 · see citing works
Zhang, S., Ren, S.-J., Zhu, D., Liu, T., Wang, L. Y., Zhao, J., Fan, X., & Gong, H. (2024) · BMC Medical Education · doi:10.1186/s12909-024-06291-4 · Cited by 63 · see citing works
Zheng, K., Shen, Z., Chen, Z., Che, C., & Zhu, H. (2024) · BMC Medical Education · doi:10.1186/s12909-024-05977-z · Cited by 55 · see citing works
Ge, W., Zhu, X.-Y., Lin, J., Jiang, J., Li, T., Lu, Y., Mi, Y., & Tung, T. (2025) · BMC Medical Education · doi:10.1186/s12909-025-06951-z · Cited by 44 · see citing works
Yang, P., Yang, L., Qi, A., Zhang, L., Xiong, R., & Chen, G. (2023) · Journal of surgical education · doi:10.1016/j.jsurg.2023.03.001 · Cited by 30 · see citing works
Sujanem, R., & Suwindra, I. N. P. (2023) · Jurnal Pendidikan IPA Indonesia · doi:10.15294/jpii.v12i1.39971 · Cited by 26 · see citing works
Zhang, J., Chen, H., Wang, X., Huang, X., & Xie, D. (2024) · BMC Medical Education · doi:10.1186/s12909-024-05343-z · Cited by 21 · see citing works
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Xu, W., Ye, T., & Wang, X. (2021) · Medicine · doi:10.1097/md.0000000000027402 · Cited by 18 · see citing works
Self-citationSolano, J., Gutiérrez, M. Z., Guzmán, E. P., & Henriquez, G. S. (2023) · Cureus · doi:10.7759/cureus.43187 · Cited by 17 · see citing works
Bukumirić, Z., Ilic, A., Pajčin, M., Srebro, D., Milićević, S., Spaić, D., Marković, N., & Corac, A. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263015 · Cited by 16 · see citing works
Shang, Y., Cao, K.-F., Yue, J.-Y., Zhao, S.-Z., Hao, S.-H., Sun, Y.-Z., Cui, Q.-Y., Guo, H., & Tang, C. (2025) · BMC Medical Education · doi:10.1186/s12909-024-06267-4 · Cited by 15 · see citing works
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Rahmawati, F., Sarwanto, S., & Budiawanti, S. (2021) · Momentum Physics Education Journal · doi:10.21067/mpej.v5i2.5740 · Cited by 13 · see citing works
Kim, Y. J. (2023) · Medicine · doi:10.1097/md.0000000000035143 · Cited by 12 · see citing works
Wang, Z., Li, M., Hu, B., & Niu, L. (2024) · Journal of Dental Education · doi:10.1002/jdd.13672 · Cited by 8 · see citing works
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Salari, M., Zarifi, A., & Tarmizi, R. A. (2021) · Journal of Clinical Care and Skills · doi:10.52547/jccs.2.1.21 · Cited by 8 · see citing works
Yu, X., Qin, L., Huang, G., & He, X. (2023) · Journal of the Pakistan Medical Association · doi:10.47391/jpma.6676 · Cited by 8 · see citing works
Jia, F., Wang, M., Lv, Q., Li, D., Jiang, H., Fu, G., & Zhang, W. (2025) · BMC Medical Education · doi:10.1186/s12909-025-06939-9 · Cited by 5 · see citing works
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Zhang, G., Cao, Y., Zhao, X., Zhu, X., & Mao, K. (2025) · Journal of surgical education · doi:10.1016/j.jsurg.2025.103699 · Cited by 4 · see citing works
Anthony, L., Radha, A., Indushree, T., & Banerjee, S. (2024) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.1177/0976500x241285990 · Cited by 4 · see citing works
Sun, X., Ding, M., Luo, X., Kang, B., Zhu, Y., Xu, Z., & Chen, C. (2022) · BMC Medical Education · doi:10.1186/s12909-022-03311-z · Cited by 4 · see citing works
Tang, H., Ming, J. S., & Yong, C. (2020) · Creative Education · doi:10.4236/ce.2020.1112193 · Cited by 3 · see citing works
Problem-based learning in medical degree teaching: a scoping reviewPreprint
Trullàs, J. C., Blay, C., Sarri, E., & Pujol, R. (2021) · Research Square · doi:10.21203/rs.3.rs-514038/v1 · Cited by 3 · see citing works
Clendinneng, D., Yeratziotis, A., Vanezi, E., Costa, T., Muscat, L., Cassar, M., Filomeno, L., MacDonald, C., Mettouris, C., Papadopoulos, G. A., et al. (2022) · Cogent Education · doi:10.1080/2331186x.2022.2127480 · Cited by 2 · see citing works
Chen, X., Xiao, Y., You, Y., Zhu, J., Liu, S., Chen, H., & Zhu, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0315455 · Cited by 2 · see citing works
Xu, Y., Xing, J., Wulan, H., & Guo, L. (2022) · Chinese Journal of Plastic and Reconstructive Surgery · doi:10.1016/j.cjprs.2022.09.014 · Cited by 1 · see citing works
Zhang, R., Gan, K., Zuo, H., Han, D., Shi, K., Wang, J., Zhang, K., Jiang, W., Wang, D., & Yu, L. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1452165 · Cited by 1 · see citing works
Noroozi, H. A., Sharifi, N., Joveini, H., Rakhshani, M. H., & Anbrani, M. A. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07244-w · Cited by 1 · see citing works
Saudagar, F. N. I., & Madadin, M. S. (2025) · Journal of Family and Community Medicine · doi:10.4103/jfcm.jfcm_195_25 · Cited by 1 · see citing works
Tang, J., Yang, J. X., yang, J., & Wei, S. (2026) · Gastroenterology Research and Practice · doi:10.1155/grp/8457575 · Cited by 1 · see citing works
Problem-based learning in dentistry: learner satisfaction survey
ELHIJAZI, M., Benyahya, I., & ELHIJAZI, M. (2023) · Health Sciences · doi:10.56264/2658-865x.1079 · Cited by 1 · see citing works
Student satisfaction in clinical area subjects during the COVID-19 pandemic in a medical school
Lazo, A. D., Álvarez-Risco, A., Rosales, C. C., Rosales, S. C., Ruiz-Aquino, M., Del-Aguila-Arcentales, S., Davies, N. M., Mejia, C. R., & Yáñez, J. A. (2024) · Frontiers in Education · doi:10.3389/feduc.2023.1217317 · Cited by 1 · see citing works
Zarida, H., Zarifi, A., Zoladl, M., & Salari, M. (2021) · Journal of Clinical Care and Skills · doi:10.52547/jccs.2.3.113 · Cited by 1 · see citing works
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Zhang, X., Guo, Y., Wang, J., Zhang, X., Cheng, J., Chen, H., & Pi, Q. (2023) · African Health Sciences · doi:10.4314/ahs.v23i2.36 · Cited by 1 · see citing works
Zhou, T., Chen, Y., Xu, R., & Chun, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-185432/v1
Sun, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.26.445870
Monteiro, D. L. C., Santos, J. C., da Silva, G. A., da Conceição, A. R. S., Lima, K. O., Ribeiro, S. D. S., Ribeiro, E. D. S., Freitas, F. M. D. S., Silva, M. D. M. E., Carodoso, J. R. M., et al. (2023) · International Journal of Advanced Engineering Research and Science · doi:10.22161/ijaers.101.20
Chandran, N., & Menon, V. B. (2023) · Kerala Journal of Psychiatry · doi:10.30834/kjp.35.2.2023.313
高, 井. (2023) · Creative Education Studies · doi:10.12677/ces.2023.1111513
Li, Y., & Zhu, R. (2024) · Research Square · doi:10.21203/rs.3.rs-3736601/v1
Ye, T., Wan, H., Song, C. Q., Quan, J., Zhou, J., Deng, J., Dai, B., & Yang, M. (2024) · Pacific International Journal · doi:10.55014/pij.v7i1.501
Ma, C., Liu, J., Xue, X., Miao, B., Xu, F., Man, J., Nyalali, A. M. K., & Zhang, K. (2025) · Journal of Cancer Education · doi:10.1007/s13187-025-02596-0
Sun, X., Ding, M., Luo, X., Kang, B., Zhu, Y., Xu, Z., & Chen, C. (2022) · Figshare · doi:10.6084/m9.figshare.19581902
Trullàs, J. C., Blay, C., Sarri, E., & Pujol, R. (2022) · Figshare · doi:10.6084/m9.figshare.19194104
Sun, X., Ding, M., Luo, X., Kang, B., Zhu, Y., Xu, Z., & Chen, C. (2022) · Figshare · doi:10.6084/m9.figshare.19581899
Sun, X., Ding, M., Luo, X., Kang, B., Zhu, Y., Xu, Z., & Chen, C. (2022) · Figshare · doi:10.6084/m9.figshare.19581896
Huang, S., Feng, Y., Wang, L., Yu, J., Yao, L., & Guo, Q. (2026) · Research Square · doi:10.21203/rs.3.rs-8345918/v1
Opportunities and challenges in the development of neurology medical education in China
Song, Y., Chu, J., Yao, X., Pan, Y., Zhi, N., Cao, W., Ruolian, D. A. I., Lu, Z., & Wang, G. (2026) · Global Medical Education · doi:10.1515/gme-2025-0015
Zhang, Y., & Zeng, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1780896
Ou, H., Lin, H., Xu, H., Mo, L., Yuan, D., Fang, G., Xiao, X., Zeng, E., Huang, X., Fang, C., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8979230/v1
Sujanem, R., Suma, K., Yasa, P., Yuliana, I., & Sarini, P. (2026) · Jurnal Penelitian Pendidikan IPA · doi:10.29303/jppipa.v12i6.14040
Liu, J., Su, J., Xia, W., & Hou, M. (2026) · Frontiers in Education · doi:10.3389/feduc.2026.1756947
Stupchuk, M. S., & Чеберніна, І. О. (2026) · Український журнал екстремальної медицини ім Г О Можаєва · doi:10.32782/3083-7324/2026.3.6
- Authors
- Liu, C.-X., Ouyang, W.-W., Wang, X.-W., Chen, D., & Jiang, Z.-L.
- Affiliations
- Office of Postgraduate Education and Training, The First Affiliated Hospital of Chongqing Medical University
- Office of Education and Training, Chongqing Health Service Center
- Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing
- Department of Cardiothoracic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Venue
- Medicine
- Published
- 2020-04
- Volume
- 99
- Issue
- 16
- Pages
- e19687
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC7220526
- OpenAlex
- W3017244233
- Cited by
- 53
- References
- 5
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Division of Graduate Education
- Topics
- Social Sciences › Education › Problem and Project Based Learning
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Innovations in Medical Education
- Physical Sciences › Engineering › Biomedical Engineering › Biomedical and Engineering Education
- Keywords
- problem-based learning, lecture-based learning, hybrid teaching, clinical curriculum, medical students, clinical skills, medical knowledge, teaching satisfaction, medical education, Chinese medical education
- MeSH terms
- China, Clinical Competence, Education, Medical, Humans, Learning, Students, Medical, Randomized Controlled Trials as Topic, Problem-Based Learning
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