Novel coronavirus 2019 (COVID-19): A case report and review of treatments
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RATIONALE: Novel coronavirus 2019 (COVID-19) also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, non-segmented positive-sense RNA virus belonging to the beta-coronaviridae family. This virus is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS) which can lead to difficulty breathing requiring mechanical ventilation and intensive care unit management. PATIENT CONCERNS: A 77-year-old female with a history of hypertension and hyperlipidemia who presented as a transfer to our hospital facility with worsening fevers, cough, and respiratory distress. DIAGNOSIS: Chest X-rays revealed bilateral infiltrates worse at the lung bases and CT scan of the chest showed bilateral ground-glass opacities consistent with COVID-19. While our testing revealed a negative COVID-19 result at our institution, the result at a previous hospital returned a positive result. INTERVENTIONS: She was being treated aggressively in the intensive care unit with high dose intravenous ascorbic acid, hydroxychloroquine, and anti-interleukin-6 monoclonal antibody. She also received a loading dose of remdesivir however was unable to complete the course due to organ failure and requirement of vasopressors for hemodynamic stability. OUTCOMES: She remained critically ill and was eventually placed on comfort care as per the family's wishes and passed away. LESSONS: With a rapidly growing death rate and more than 200,000 confirmed cases worldwide, COVID-19 has become a global pandemic and major hit to our healthcare systems. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. The alarming increase in cases per day adds additional pressure to find a cure and decrease the global health burden and mortality rate.
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SARS-CoV-2 infection is more severe in pregnant women compared to nonpregnant counterparts, with increased risk of hospital admission, ICU stay, and death.
“SARS-CoV-2 infection is more severe in pregnant women compared to their non-pregnant counterparts, with an increased risk of hospital admission, ICU stay, and death 2 .”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [28]
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Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study
Gray, K. J., Bordt, E. A., Atyeo, C., Deriso, E., Akinwunmi, B., Young, N., Baez, A. M., Shook, L. L., Cvrk, D., James, K., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.03.023 · Cited by 699 · see citing works
- Authors
- Douedi, S., & Miskoff, J.
- Affiliations
- Jersey Shore University Medical Center (US)
- Seton Hall University (US)
- Corresponding author
- Douedi, Steven
- ORCID
- Douedi, Steven
- Venue
- Medicine
- Published
- 2020-05
- Volume
- 99
- Issue
- 19
- Pages
- e20207
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC7220032
- OpenAlex
- W3021523230
- Cited by
- 135
- References
- 17
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 13 · 2022: 37 · 2021: 37 · 2020: 35
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- COVID-19 pandemic, SARS-CoV-2, bilateral pneumonia, acute respiratory distress syndrome, ground-glass opacities, intensive care management, hydroxychloroquine, vitamin C, remdesivir, organ failure, vasopressors, critically ill elderly patients
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, COVID-19 Drug Treatment, Adenosine Monophosphate, Aged, Alanine, Antimalarials, Antiviral Agents, Female, Humans, Hydroxychloroquine, Pneumonia, Viral, Respiratory Distress Syndrome, Fatal Outcome, Coronavirus Infections, Clinical Laboratory Techniques, Pandemics
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