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Cited by 135Thyroid Disorders and TreatmentsChronic Kidney Disease and DiabetesDialysis and Renal Disease Management

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

The interaction between thyroid and kidney disease: an overview of the evidence.

Open access
Rhee, Connie M.·2016·Current Opinion in Endocrinology, Diabetes & Obesity
DOI 10.1097/med.0000000000000275PMC PMC5094898
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Abstract

PURPOSE OF REVIEW: Hypothyroidism is highly prevalent in chronic kidney disease (CKD) patients, including those receiving dialysis. This review examines potential mechanistic links between thyroid and kidney disease; current evidence for hypothyroidism as a risk factor for de novo CKD and CKD progression; and studies of thyroid functional disorders, cardiovascular disease, and death in the CKD population. RECENT FINDINGS: Epidemiologic data have demonstrated an incrementally higher prevalence of hypothyroidism with increasing severity of kidney dysfunction. Various thyroid functional test abnormalities are also commonly observed in CKD due to alterations in thyroid hormone synthesis, metabolism, and regulation. Although the mechanistic link between thyroid and kidney disease remains unclear, observational studies suggest that hypothyroidism is associated with abnormal kidney structure and function. Previously thought to be a physiologic adaptation, recent studies show that hypothyroidism is associated with higher risk of cardiovascular disease and death in CKD. SUMMARY: A growing body of evidence suggests that hypothyroidism is a risk factor for incident CKD, CKD progression, and higher death risk in kidney disease patients. Rigorous studies are needed to determine the impact of thyroid hormone replacement upon kidney disease progression, cardiovascular disease, and mortality, which may shed light onto the causal implications of hypothyroidism in CKD.

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  1. Soldin, 2013, Measuring serum thyroid-stimulating hormone, thyroid hormones, thyroid-directed antibodies, and transport proteins, Werner and Ingbar's the thyroid, 279

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Metadata

Authors
Rhee, C. M.
Affiliations
University of California, Irvine (US)
Corresponding author
Rhee, Connie M.
ORCID
Rhee, Connie M.
Venue
Current Opinion in Endocrinology, Diabetes & Obesity
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-10
Volume
23
Issue
5
Pages
407-415
ISSN
  • 1752-296X (ISSN-L)
  • 1752-2978
DOI
10.1097/med.0000000000000275
PMC
PMC5094898
OpenAlex
W2473748378
Cited by
135
References
80
Citations by year
2026: 14 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 16 · 2021: 20 · 2020: 21 · 2019: 8 · 2018: 7 · 2017: 1
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (K23DK102903)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
hypothyroidism, chronic kidney disease, dialysis, chronic kidney disease progression, cardiovascular disease, mortality, thyroid hormone metabolism, thyroid hormone replacement, thyroid dysfunction
MeSH terms
Humans, Hypothyroidism, Renal Insufficiency, Chronic

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