The DOI matches its Crossref record; 73 of the 75 references it cites were found in a registry or an index.
Brown fat as a therapy for obesity and diabetes
Open accessAbstract
PURPOSE OF REVIEW: Human fat consists of white and brown adipose tissue (WAT and BAT). Though most fat is energy-storing WAT, the thermogenic capacity of even small amounts of BAT makes it an attractive therapeutic target for inducing weight loss through energy expenditure. This review evaluates the recent discoveries regarding the identification of functional BAT in adult humans and its potential as a therapy for obesity and diabetes. RECENT FINDINGS: Over the past year, several independent research teams used a combination of positron-emission tomography and computed tomography (PET/CT) imaging, immunohistochemistry, and gene and protein expression assays to prove conclusively that adult humans have functional BAT. This has occurred against a backdrop of basic studies defining the origins of BAT, new components of its transcriptional regulation, and the role of hormones in stimulation of BAT growth and differentiation. SUMMARY: Adult humans have functional BAT, a new target for antiobesity and antidiabetes therapies focusing on increasing energy expenditure. Future studies will refine the methodologies used to measure BAT mass and activity, expand our knowledge of critical-control points in BAT regulation, and focus on testing pharmacological agents that increase BAT thermogenesis and help achieve long-lasting weight loss and an improved metabolic profile.
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“BAT is especially abundant in hibernating mammals 74 , but can also be found in adult humans 75.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [75]
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Cites
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Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
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Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit
Li, Z., Yi, C.-X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C. K., Gao, Y., van den Heuvel, J. K., Meijer, O. C., Berbée, J. F. P., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314050 · Cited by 674
Estrogen deficiency and the origin of obesity during menopause
Lizcano, F., & Guzmán, G. (2014) · BioMed Research International · doi:10.1155/2014/757461 · Cited by 586
“The majority of these factors can be classified into different categories [6–9] such as (1) factors responsible for the hormonal regulation of appetite and satiety; (2) factors that regulate body glucose levels [10–12]; (3) regulators of basal metabolic rate [13, 14]; (4) factors that control the quantity, disposition…”
BackgroundThe adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
Vitali, A., Murano, I., Zingaretti, M. C., Frontini, A., Ricquier, D., & Cinti, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m018846 · Cited by 487
Berberine activates thermogenesis in white and brown adipose tissue
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Structural and biochemical characteristics of various white adipose tissue depots
Wrońska, A., & Kmieć, Z. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02409.x · Cited by 402
“…et al. 2008) and the discovery of inducible brown adipocyte progenitors residing in human subcutaneous adipose tissue (SAT) (and skeletal muscles) (Schulz et al. 2011) pose a promising new target for antiobesity and antidiabetes therapies based on increasing energy expenditure (Cypess & Kahn 2010).”
Background
Metadata
- Authors
- Cypess, A. M., & Kahn, C. R.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Kahn, C Ronald
- Venue
- Current Opinion in Endocrinology, Diabetes & Obesity
- Published
- 2010-04
- Volume
- 17
- Issue
- 2
- Pages
- 143-149
- ISSN
- 1752-296X (ISSN-L)
- PMC
- PMC3593105
- OpenAlex
- W2061096962
- Cited by
- 376
- References
- 75
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 11 · 2023: 28 · 2022: 25 · 2021: 36 · 2020: 34 · 2019: 37 · 2018: 28 · 2017: 29 · 2016: 18 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 27
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (RC1DK087317, DK-082659, K23DK081604, P30DK046200, DK046200, DK087317, DK081604, P30DK036836, R01DK082659)
- National Center for Research Resources (KL2RR025757, RR025757)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- brown adipose tissue, obesity, type 2 diabetes, thermogenesis, energy expenditure, weight loss, bat origin
- MeSH terms
- Animals, Adipose Tissue, Brown, Diabetes Mellitus, Humans, Models, Biological, Obesity, Anti-Obesity Agents, Thermogenesis, Body Fat Distribution, Cell Transdifferentiation, Cell- and Tissue-Based Therapy
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