Cited by 104Hormonal and reproductive studiesEstrogen and related hormone effectsSexual Differentiation and Disorders

Evolving utility of sex hormone-binding globulin measurements in clinical medicine

Hammond, Geoffrey L., Wu, Tsung-Sheng, Simard, Marc·2012·Current Opinion in Endocrinology, Diabetes & Obesity

Abstract

PURPOSE OF REVIEW: Sex hormone-binding globulin (SHBG) regulates the plasma levels and biological actions of the sex steroids: testosterone and estradiol. Advances in our understanding of how plasma SHBG levels are determined, and how SHBG functions, have provided insight into how SHBG should be used to assess the actions of its sex-steroid ligands, and as a biomarker of metabolic and endocrine abnormalities. RECENT FINDINGS: Plasma SHBG levels fluctuate throughout life in response to the changes in metabolic and physiologic states, and are altered by natural hormones and synthetic steroids. Interindividual differences in plasma SHBG levels and activity are also influenced by polymorphisms within the structural and regulatory regions of the SHBG gene. SUMMARY: Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. It is anticipated that new genetic and functional data regarding SHBG will reveal whether SHBG is simply a biomarker of these diseases or participants in their cause.

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Crossref · 10.1097/med.0b013e328353732f

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Authors
Hammond, G. L., Wu, T.-S., & Simard, M.
Affiliations
University of British Columbia (CA)
Corresponding author
Hammond, Geoffrey L.
Venue
Current Opinion in Endocrinology, Diabetes & Obesity
Published
2012-06
Volume
19
Issue
3
Pages
183-189
ISSN
1752-296X (ISSN-L)
OpenAlex
W2145626737
Cited by
104
References
53
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 1
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canada Research Chairs
  • Canadian Institutes of Health Research (MOP 15261)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
sex hormone-binding globulin, free testosterone, sex steroids, metabolic syndrome, type 2 diabetes, cardiovascular disease, endocrine disorders, biomarkers, hyperandrogenism
MeSH terms
Estradiol, Female, Humans, Male, Polymorphism, Genetic, Predictive Value of Tests, Risk, Sex Hormone-Binding Globulin, Testosterone, Biomarkers, Sex Distribution, Metabolic Syndrome

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