Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men
Open accessAbstract
Despite its widespread clinical use, there is little data available from population-based studies on the determinants of serum sex hormone binding globulin (SHBG). We aimed to examine multifactorial determinants of circulating SHBG levels in community-dwelling men. Study participants comprised randomly selected 35-80 y.o. men (n = 2563) prospectively-followed for 5 years (n = 2038) in the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study. After excluding men with illness or medications known to affect SHBG (n = 172), data from 1786 men were available at baseline, and 1476 at follow-up. The relationship between baseline body composition (DXA), serum glucose, insulin, triglycerides, thyroxine (fT4), sex steroids (total testosterone (TT), oestradiol (E2)), and pro-inflammatory cytokines and serum SHBG level at both baseline & follow-up was determined by linear and penalized logistic regression models adjusting for age, lifestyle & demographic, body composition, metabolic, and hormonal factors. Restricted cubic spline analyses was also conducted to capture possible non-linear relationships. At baseline there were positive cross-sectional associations between age (β = 0.409, p<0.001), TT (β = 0.560, p<0.001), fT4 (β = 0.067, p = 0.019) and SHBG, and negative associations between triglycerides (β = -0.112, p<0.001), abdominal fat mass (β = -0.068, p = 0.032) and E2 (β = -0.058, p = 0.050) and SHBG. In longitudinal analysis the positive determinants of SHBG at 4.9 years were age (β = 0.406, p = <0.001), TT (β = 0.461, p = <0.001), and fT4 (β = 0.040, p = 0.034) and negative determinants were triglycerides (β = -0.065, p = 0.027) and abdominal fat mass (β = -0.078, p = 0.032). Taken together these data suggest low SHBG is a marker of abdominal obesity and increased serum triglycerides, conditions which are known to have been associated with low testosterone and low T4.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obesity has been reported to be associated with lower circulating levels of SHBG.
“Obesity has been reported to be associated with lower circulating levels of SHBG.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [222]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of late-onset hypogonadism in middle-aged and elderly men
Wu, F. C. W., Tajar, A., Beynon, J. M., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Forti, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911101 · Cited by 1,544 · see citing works
ANDERSON, D. C. (1974) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1974.tb03298.x · Cited by 1,127 · see citing works
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693 · see citing works
Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455 · see citing works
Novel insights in SHBG regulation and clinical implications
Simó, R., Sáez-López, C., Barbosa-Desongles, A., Hernández, C., & Selva, D. M. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.05.001 · Cited by 335 · see citing works
Diverse Roles for Sex Hormone-Binding Globulin in Reproduction
Hammond, G. L. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092593 · Cited by 317 · see citing works
Sex hormone binding globulin and insulin resistance
Wallace, I. R., McKinley, M. C., Bell, P. M., & Hunter, S. J. (2013) · Clinical Endocrinology · doi:10.1111/cen.12086 · Cited by 268 · see citing works
Gapstur, S. M., Gann, P. H., Kopp, P. A., Colangelo, L. A., Longcope, C., & Liu, K. (2002) · PubMed · Cited by 247 · see citing works
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
Selva, D. M., Hogeveen, K. N., Innis, S. M., & Hammond, G. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32249 · Cited by 232 · cited 4× · see citing works
“Factors shown to be inversely associated with SHBG levels include growth hormone [14], oestrogen (oestradiol) [15, 16], insulin [15, 17], body composition [15, 18, 19], intrahepatic fat [8, 18, 20], triglycerides [21, 22], monosaccharides [23], C-reactive protein (CRP) [24], and moderate alcohol consumption [25].”
BackgroundInfluentialThe effect of storage time and freeze-thaw cycles on the stability of serum samples
ÇUHADAR, S., Köseoğlu, M., Atay, A., & Dirican, A. (2013) · Biochemia Medica · doi:10.11613/bm.2013.009 · Cited by 198 · see citing works
Shiels, M. S., Rohrmann, S., Menke, A., Selvin, E., Crespo, C. J., Rifai, N., Dobs, A., Feinleib, M., Guallar, E., & Platz, E. A. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9318-y · Cited by 166 · see citing works
Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
Peter, A., Kantartzis, K., Machann, J., Schick, F., Staiger, H., Machicao, F. E., Schleicher, E. D., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0179 · Cited by 156 · see citing works
Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome
PUGEAT, M. M., Nader, N., Hogeveen, K. N., Raverot, G., Déchaud, H., & Grenot, C. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.020 · Cited by 150 · see citing works
Liu, P. Y., Beilin, J., Meier, C., Nguyen, T. V., Center, J. R., Leedman, P. J., Seibel, M. J., Eisman, J. A., & Handelsman, D. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0862 · Cited by 142 · see citing works
Thaler, M. A., Seifert-Klauss, V., & Luppa, P. B. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.06.005 · Cited by 125 · see citing works
Selva, D. M., & Hammond, G. L. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0025 · Cited by 124 · see citing works
Handelsman, D. J., Sikaris, K., & Ly, L. P. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563215610589 · Cited by 122 · see citing works
Antonio, L., Wu, F. C. W., O’Neill, T. W., Pye, S. R., Carter, E. L., Finn, J. D., Rutter, M. K., Laurent, M. R., Huhtaniemi, I. T., Han, T. S., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4184 · Cited by 119 · see citing works
Cooper, L. A., Page, S. T., Amory, J. K., Anawalt, B. D., & Matsumoto, A. M. (2015) · Clinical Endocrinology · doi:10.1111/cen.12768 · Cited by 117 · see citing works
Evolving utility of sex hormone-binding globulin measurements in clinical medicine
Hammond, G. L., Wu, T.-S., & Simard, M. (2012) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328353732f · Cited by 104 · see citing works
Sex Hormone-Binding Globulin Changes with Androgen Replacement
Plymate, S. R., LEONARD, J. M., Paulsen, C. A., Fariss, B. L., & Karpas, A. E. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-645 · Cited by 101 · see citing works
Wang, Q., Kangas, A. J., Soininen, P., Tiainen, M., Tynkkynen, T., Puukka, K. S., Ruokonen, A., Viikari, J. S. A., Kähönen, M. A. P., Lehtimäki, T. J., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv093 · Cited by 100 · see citing works
de Ronde, W., van der Schouw, Y. T., Muller, M., Grobbee, D. E., Gooren, L. J., Pols, H. A. P., & de Jong, F. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0422 · Cited by 97 · see citing works
Jänne, M., & Hammond, G. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34105 · Cited by 94 · see citing works
Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men
Gautier, A., Bonnet, F., Dubois, S., Massart, C., Grosheny, C., Bachelot, A., Aubé, C., Balkau, B., & Ducluzeau, P. (2013) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04401.x · Cited by 91 · see citing works
Association between endogenous sex steroid hormones and inflammatory biomarkers in US men
Tsilidis, K. K., Rohrmann, S., McGlynn, K. A., Nyante, S. J., López, D. S., Bradwin, G., Feinleib, M., Joshu, C. E., Kanarek, N., Nelson, W. G., et al. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00129.x · Cited by 88 · see citing works
Androgens, Estrogens, and Sex Hormone-Binding Globulin in Middle-Aged Men*
Longcope, C., GOLDFIELD, S. R. W., Brambilla, D. J., & McKinlay, J. B. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1442 · Cited by 84 · see citing works
Sex Steroid Hormone Levels and Body Composition in Men
Gates, M. A., Mekary, R. A., Chiu, G. R., Ding, E. L., Wittert, G., & de Araújo, A. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2582 · Cited by 84 · see citing works
Self-citationSex Hormone-Binding Globulin: Gene Organization and Structure/Function Analyses
Hammond, G. L., & Bocchinfuso, W. P. (2008) · Hormone Research · doi:10.1159/000184787 · Cited by 83 · see citing works
Kopper, N. (2008) · Drug Design Development and Therapy · doi:10.2147/dddt.s4146 · Cited by 83 · see citing works
Adiponectin upregulates SHBG production: molecular mechanisms and potential implications.
Simó, R., Sáez-López, C., Lecube, A., Hernández, C., Fort, J., & Selva, D. (2014) · Endocrinology · doi:10.1210/en.2014-1072 · Cited by 81 · see citing works
Sex Hormone-Binding Globulin Gene Expression and Insulin Resistance
Winters, S. J., Gogineni, J., Karegar, M., Scoggins, C., Wunderlich, C. A., Baumgartner, R., & Ghooray, D. T. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2640 · Cited by 79 · see citing works
Loukovaara, M. J., Carson, M., & Adlercreutz, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829605 · Cited by 77 · see citing works
LEE, I. R., DAWSON, S. A., Wetherall, J. D., & Hähnel, R. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-4-825 · Cited by 77 · see citing works
Firtser, S., Juonala, M., Magnussen, C. G., Jula, A., Loo, B.-M., Marniemi, J., Viikari, J. S. A., Toppari, J., Perheentupa, A. H., Hutri‐Kähönen, N., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.020 · Cited by 69 · see citing works
Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression.
Simó, R., Barbosa-Desongles, A., Sáez-López, C., Lecube, A., Hernández, C., & Selva, D. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1321 · Cited by 68 · see citing works
Cohort Profile: The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study
Grant, J. F., Martin, S., Taylor, A. W., Wilson, D. H., de Araújo, A. B., Adams, R. J., Jenkins, A. J., Milne, R. W., Hugo, G. J., Atlantis, E. E., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt064 · Cited by 67 · see citing works
Self-citationPeroxisome-Proliferator Receptor γ Represses Hepatic Sex Hormone-Binding Globulin Expression
Selva, D. M., & Hammond, G. L. (2009) · Endocrinology · doi:10.1210/en.2008-1289 · Cited by 65 · see citing works
Sex Hormone Binding Globulin and Aging
Caldwell, J., & Jirikowski, G. (2008) · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · doi:10.1055/s-0028-1093351 · Cited by 64 · see citing works
Yeap, B. B., Knuiman, M. W., Divitini, M., Handelsman, D. J., Beilby, J. P., Beilin, J., McQuillan, B., & Hung, J. (2014) · Clinical Endocrinology · doi:10.1111/cen.12407 · Cited by 60 · see citing works
Gyawali, P., Martin, S., Heilbronn, L. K., Vincent, A. D., Taylor, A. W., Adams, R., O’Loughlin, P. D., & Wittert, G. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1163-6 · Cited by 56 · see citing works
Self-citationKim, C., Dabelea, D., Kalyani, R. R., Christophi, C. A., Bray, G. A., Pi-Sunyer, X., Darwin, C. H., Yalamanchi, S., Barrett-Connor, E. L., Golden, S. H., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00967 · Cited by 54 · see citing works
Resistance training increases SHBG in overweight/obese, young men
Roberts, C. K., Croymans, D. M., Aziz, N., Butch, A. W., & Lee, C. C. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.004 · Cited by 50 · see citing works
Evaluation of Differences Between Fan-Beam and Pencil-Beam Densitometers
Mazess, R. B., & Barden, H. S. (2000) · Calcified Tissue International · doi:10.1007/s002230001147 · Cited by 46 · see citing works
Goto, A., Morita, A., Goto, M., Sasaki, S., Miyachi, M., Aiba, N., Terauchi, Y., Noda, M., Watanabe, S., & the Saku Cohort Study Group (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-130 · Cited by 43 · see citing works
Sex Hormone–Binding Globulin and Testosterone in Individuals With Childhood Diabetes
Danielson, K. K., Drum, M. L., & Lipton, R. B. (2008) · Diabetes Care · doi:10.2337/dc07-2169 · Cited by 43 · see citing works
Flechtner-Mors, M., Schick, A., Oeztuerk, S., Haenle, M., Wilhelm, M., Koenig, W., Imhof, A., Boehm, B. O., Graeter, T., Mason, R., et al. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1354369 · Cited by 42 · see citing works
Canoy, D., Barber, T. M., Pouta, A., Hartikainen, A. L., McCarthy, M. I., Franks, S., Järvelin, M., Tapanainen, J. S., Ruokonen, A., Huhtaniemi, I. T., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1046 · Cited by 40 · see citing works
Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training
He, Z., Rankinen, T., Leon, A. S., Skinner, J. S., Tchernof, A., & Bouchard, C. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0033-1 · Cited by 40 · see citing works
Comparative effects of GH, IGF‐I and insulin on serum sex hormone binding globulin
Gafny, M., Silbergeld, A., Kilnger, B., Wasserman, M., & Laron, Z. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02526.x · Cited by 39 · see citing works
Dumoulin, S. C., Perret, B., Bennet, A., & Caron, P. J. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1320594 · Cited by 39 · see citing works
Free estradiol and sex hormone-binding globulin
Rosner, W. (2014) · Steroids · doi:10.1016/j.steroids.2014.08.005 · Cited by 38 · see citing works
Trabert, B. L., Graubard, B. I., Nyante, S. J., Rifai, N., Bradwin, G., Platz, E. A., McQuillan, G. M., & McGlynn, K. A. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-0024-9 · Cited by 38 · see citing works
Hsu, B., Cumming, R. G., Blyth, F., Naganathan, V., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3984 · Cited by 33 · see citing works
Age-related changes in estradiol and longitudinal associations with fat mass in men
Wu, A., Shi, Z., Martin, S., Vincent, A. D., Heilbronn, L. K., & Wittert, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201912 · Cited by 33 · see citing works
Self-citationVanbillemont, G., Lapauw, B., Naeyer, H. D., Roef, G. L., Kaufman, J., & Taes, Y. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04155.x · Cited by 32 · see citing works
Endogenous sex hormones and C‐reactive protein in healthy chinese men
Zhang, Y., Gao, Y., Tan, A., Yang, X., Zhang, H., Zhang, S., Wu, C., Lu, Z., Wang, M., Liao, M., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04359.x · Cited by 30 · see citing works
Bonnet, F., Velayoudom Cephise, F., Gautier, A., Dubois, S., Massart, C., Camara, A., Larifla, L., Balkau, B., & Ducluzeau, P. (2013) · Clinical Endocrinology · doi:10.1111/cen.12089 · Cited by 28 · see citing works
Sáez-López, C., RIVERA-GIMENEZ, M., Hernández, C., Simó, R., & Selva, D. (2015) · Endocrinology · doi:10.1210/en.2015-1677 · Cited by 28 · see citing works
Loukovaara, M. J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.1.160 · Cited by 25 · see citing works
Oleic acid increases hepatic sex hormone binding globulin production in men
Sáez‐López, C., Soriguer, F., Hernández, C., Rojo‐Martínez, G., Rubio‐Martín, E., Simó, R., & Selva, D. M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300304 · Cited by 24 · see citing works
Sáez‐López, C., Briansó‐Llort, L., Torres‐Torronteras, J., Simó, R., Hammond, G. L., & Selva, D. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-12509-x · Cited by 24 · see citing works
Pascual-Figal, D. A., Tornel, P. L., Nicolás, F., Sánchez‐Más, J., Martínez, M. D., Gracia, M. R., Garrido, I. P., Ruipérez, J. A., & Valdés, M. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73532-7 · Cited by 23 · see citing works
Tong, G., Hua, X., Zhong, Y., Zhang, K., Gu, G., Feng, W., Huang, H., Wang, W., Li, L., Sun, Y., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0557 · Cited by 23 · see citing works
Pascual-Figal, D. A., Tornel, P. L., Nicolás, F., Sánchez‐Más, J., Martínez, M. D., Gracia, M. R., Garrido, I. P., Ruipérez, J. A., & Valdés, M. (2009) · Revista Española de Cardiología · doi:10.1016/s0300-8932(09)73123-9 · Cited by 22 · see citing works
Testosterone, SHBG and differential white blood cell count in middle-aged and older men
Brand, J. S., van der Schouw, Y. T., Dowsett, M., Folkerd, E. J., Luben, R., Wareham, N. J., & Khaw, K. (2012) · Maturitas · doi:10.1016/j.maturitas.2011.12.007 · Cited by 22 · see citing works
Wang, N., Zhang, K., Han, B., Qin, L., Chen, Y., Zhu, C., Chen, Y., Xia, F., Zhai, H., Jiang, B., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1272-y · Cited by 21 · see citing works
Sex Hormone-Binding Globulin and the Metabolic Syndrome
Hammond, G. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-53298-1_15 · Cited by 13 · see citing works
Abdella, N., & Mojiminiyi, O. A. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.08.024 · Cited by 8 · see citing works
Papatheodorou, S., Rohrmann, S., López, D. S., Bradwin, G., Joshu, C. E., Kanarek, N., Nelson, W. G., Rifai, N., Platz, E. A., & Tsilidis, K. K. (2014) · Cancer Causes & Control · doi:10.1007/s10552-013-0336-4 · Cited by 6 · see citing works
Lee, K., Sung, J., & Song, Y. (2015) · Clinical Endocrinology · doi:10.1111/cen.12722 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [17]Daka B, Jansson PA, Rosen T, Ranullstam L, Lindblad U. Inverse correlation between serum insulin and sex hormone binding globulin in a population survey in the south-west of Sweden. Diabetologia. 2011; 54: S219.
Cited by
Sorted by citations
Metabolic Disorders and Male Hypogonadotropic Hypogonadism
Pivonello, R., Menafra, D., Riccio, E., Garifalos, F., Mazzella, M., de Angelis, C., & Colao, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00345 · Cited by 146 · see citing works
Savir, S., Wei, Z. J., Liew, J. W. K., Vythilingam, I., Lim, Y. A. L., Saad, H. M., Sim, K. S., & Tan, K. W. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128090 · Cited by 86 · see citing works
Obesity, type 2 diabetes, and testosterone in ageing men
Wittert, G., & Grossmann, M. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09746-5 · Cited by 79 · see citing works
Self-citationYeap, B. B., Marriott, R. J., Antonio, L., Chan, Y. X., Raj, S., Dwivedi, G., Reid, C. M., Anawalt, B. D., Bhasin, S., Dobs, A. S., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa743 · Cited by 67 · see citing works
Self-citationSibuh, B. Z., Khanna, S., Taneja, P., Sarkar, P., & Taneja, N. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119305 · Cited by 62 · see citing works
Abdelhalim, A. O. E., Meshcheriakov, A. A., Maistrenko, D. N., Molchanov, O., Ageev, S. V., Ivanova, D. A., Iamalova, N. R., Luttsev, M. D., Vasina, L. V., Sharoyko, V. V., et al. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112232 · Cited by 55 · see citing works
Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences
Carter, J. R., Fonkoue, I. T., Greenlund, I. M., Schwartz, C. E., Mokhlesi, B., & Smoot, C. A. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00232.2019 · Cited by 54 · see citing works
Giagulli, V. A., Castellana, M., Carbone, M. D., Pelusi, C., Ramunni, M. I., Pergola, G. D., Guastamacchia, E., & Triggiani, V. (2020) · Andrology · doi:10.1111/andr.12754 · Cited by 52 · see citing works
Aging, Cardiovascular Risk, and SHBG Levels in Men and Women From the General Population
Aribas, E., Kavousi, M., Laven, J. S. E., Ikram, M. A., & van Lennep, J. E. R. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab470 · Cited by 46 · see citing works
Gyawali, P., Martin, S., Heilbronn, L. K., Vincent, A. D., Jenkins, A. J., Januszewski, A. S., Adams, R., O’Loughlin, P. D., & Wittert, G. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01317 · Cited by 38 · see citing works
Self-citationRamachandran, S., Hackett, G. I., & Strange, R. C. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2019.06.006 · Cited by 40 · see citing works
Sarkar, M., VanWagner, L. B., Terry, J. G., Carr, J. J., Rinella, M., Schreiner, P. J., Lewis, C. E., Terrault, N., & Cohort, F. T. C. A. R. D. I. Y. A. (. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000138 · Cited by 37 · see citing works
Yeap, B. B., Marriott, R. J., Antonio, L., Bhasin, S., Dobs, A. S., Dwivedi, G., Flicker, L. A., Matsumoto, A. M., Ohlsson, C., ORWOLL, E. S., et al. (2020) · Clinical Endocrinology · doi:10.1111/cen.14342 · Cited by 35 · see citing works
Self-citationClassic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
Basualto-Alarcón, C., Llanos, P., García‐Rivas, G., Troncoso, M. F., Lagos, D., Barrientos, G. C., & Estrada, M. (2021) · International Journal of Endocrinology · doi:10.1155/2021/5527973 · Cited by 34 · see citing works
Gomes, D. C. V., de Alencar, M. V. O. B., dos Reis, A. C., de Lima, R. M. T., Santos, J. V. D. O., da Mata, A. M. O. F., Dias, A. C. S., da Costa, J. S., de Medeiros, M. D. G. F., Paz, M. F. C. J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108643 · Cited by 29 · see citing works
Graybill, S. D., Hatfield, J., Kravchenko, M. I., Beckman, D., Tate, J. M., Beauvais, A., CLERC, P. G., Davila, D., Forbes, W. L., Wardian, J., et al. (2021) · Andrology · doi:10.1111/andr.12966 · Cited by 38 · see citing works
Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works
Cai, X., Thorand, B., Hohenester, S. D., Prehn, C. P., Cecil, A., Adamski, J., Zeller, T., Dennis, A., Banerjee, R., Peters, A., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1223162 · Cited by 22 · see citing works
Testosterone, Diabetes Risk, and Diabetes Prevention in Men
Yeap, B. B., & Wittert, G. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.004 · Cited by 19 · see citing works
Self-citationDomestic violence in Mozambique: from policy to practice
Jethá, E., Keygnaert, I., Martins, E., Sidat, M., & Roelens, K. (2021) · BMC Public Health · doi:10.1186/s12889-021-10820-x · Cited by 17 · see citing works
Peyrotty, G., Brigaud, B., & Martini, R. (2020) · Marine and Petroleum Geology · doi:10.1016/j.marpetgeo.2020.104520 · Cited by 14 · see citing works
Lisco, G., Triggiani, V., Bartolomeo, N., Ramunni, M. I., Pelusi, C., Pergola, G. D., Guastamacchia, E., Jirillo, E., & Giagulli, V. A. (2023) · Basic and Clinical Andrology · doi:10.1186/s12610-022-00182-8 · Cited by 9 · see citing works
López, D. S., Liu, L., Smith‐Warner, S. A., Tsilidis, K. K., Daniel, C. R., Baillargeon, J., Rohrmann, S., Platz, E. A., & Giovannucci, E. L. (2022) · HORMONES · doi:10.1007/s42000-021-00345-8 · Cited by 8 · see citing works
Singh, P., Covassin, N., Kuniyoshi, F. H. S., Marlatt, K. L., Romero‐Corral, A., Davison, D. E., Singh, R. J., Jensen, M. D., & Somers, V. K. (2021) · Physiological Reports · doi:10.14814/phy2.15127 · Cited by 6 · see citing works
Endogenous Testosterone, Testosterone Treatment, and Cardiovascular Health Outcomes in Men
Yeap, B. B., & Anawalt, B. D. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf622 · Cited by 5 · see citing works
Matta, R. A., Farrag, H. M.-A., Saedii, A. A. F., & Abdelrahman, M. M. (2022) · The Aging Male · doi:10.1080/13685538.2022.2049744 · Cited by 5 · see citing works
Wittert, G., & Umapathysivam, M. M. (2024) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000884 · Cited by 3 · see citing works
Self-citationBrzozowska, M. M., Galiniak, S., Bliuc, D., Mazur, A., Eisman, J. A., & Greenfield, J. R. (2026) · Endocrine · doi:10.1007/s12020-026-04564-0 · Cited by 2 · see citing works
Xu, H., Zhang, H., Yang, R., Xie, X., Cao, Z., Zhao, Y. (., Lin, H., Lu, D., Bischoff, F. Z., Zhang, X., et al. (2026) · The Innovation Nutrition · doi:10.59717/j.xinn-nutri.2026.100004 · Cited by 2 · see citing works
Male hypogonadism with its systemic complications
Niedobylski, S., Laszczak, K., Warchoł, K., Marczak, A., Dobosz, M., Lewicki, M., & Obel, E. (2020) · Journal of Education Health and Sport · doi:10.12775/jehs.2020.10.09.020 · Cited by 1 · see citing works
Machalski, M., & Malchyk, O. (2020) · Cretaceous Research · doi:10.1016/j.cretres.2020.104501 · Cited by 1 · see citing works
Zhao, J. V., & Schooling, C. M. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3803355
Hong, Y.-H., Hung, K.-C., Lin, C., Hung, C.-L., Tu, S.-K., Yang, D., & Liao, C. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s483344
Biernikiewicz, M., Stołyhwo-Gofron, M., Kuryłowicz, A., Sobieszczańska, M. I., Roźek-Piechura, K., Okrzymowska, P., Markiewicz, M., Gebala, J., Majchrowska, M., & Kałka, D. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15082946
- Authors
- Gyawali, P., Martin, S. A., Heilbronn, L. K., Vincent, A. D., Jenkins, A. J., Januszewski, A. S., Taylor, A. W., Adams, R. J. T., O’Loughlin, P. D., & Wittert, G. A.
- Affiliations
- South Australian Health and Medical Research Institute (AU)
- Freemasons Foundation Centre for Men's Health (AU)
- The University of Sydney (AU)
- Queen Elizabeth Hospital (AU)
- South Australia Pathology (AU)
- Corresponding author
- Gyawali, Prabin
- Wittert, Gary A.
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-07-11
- Volume
- 13
- Issue
- 7
- Pages
- e0200078
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6040731
- OpenAlex
- W2844435616
- Cited by
- 35
- References
- 70
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 7
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (627227)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- sex hormone-binding globulin, community-dwelling men, total testosterone, free thyroxine, triglycerides, abdominal fat mass, estradiol, inflammatory cytokines, body composition, serum glucose, insulin, androgen metabolism, inflammation, aging, sex hormones, lifestyle factors, nonlinear dose-response relationship
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Humans, Longitudinal Studies, Male, Middle Aged, Sex Hormone-Binding Globulin, Cohort Studies, Biomarkers, Independent Living
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
