Gastrointestinal symptoms are associated with severity of coronavirus disease 2019: a systematic review and meta-analysis
Open accessAbstract
Objective: Studies have suggested that coronavirus disease 2019 (COVID-19) appears to be more serious in patients with gastrointestinal symptoms. This meta-analysis was conducted to explore the relationship between gastrointestinal symptoms and the severity of COVID-19. Methods: We searched PubMed, Web of Science, Science Direct, Embase, and Google Scholar on 16 October 2020, to identify observational studies that provided data on gastrointestinal symptoms and severity of COVID-19. Gastrointestinal symptoms include diarrhea, abdominal pain, nausea, and vomiting. The severe rate and the odds ratio (OR) were pooled. Heterogeneity was assessed using the I 2 statistic. Results: A total of 21 studies with 5285 patients were included in this meta-analysis. The severe rate of COVID-19 patients with diarrhea was 41.1% [95% confidence interval (CI): 31.0–51.5%], and the OR of association between diarrhea and severe COVID-19 was 1.41 (95% CI: 1.05–1.89); sensitivity analysis showed that the results for the OR and 95% CI were unstable. For abdominal pain, the severe rate and OR of association with severe COVID-19 were 59.3% (95% CI: 41.3–76.4%) and 2.76 (95% CI: 1.59–4.81), respectively; for nausea, 41.4% (95% CI: 23.2–60.7%) and 0.92 (95% CI: 0.59–1.43), respectively; for vomiting, 51.3% (95% CI: 36.8–65.8%) and 1.68 (95% CI: 0.97–2.92), respectively. Conclusion: The severe rate was more than 40% in COVID-19 patients with gastrointestinal symptoms. Abdominal pain was associated with a near 2.8-fold increased risk of severe COVID-19; the relationship between diarrhea and the severity of COVID-19 was regionally different; nausea and vomiting were limited in association with an increased risk of severe COVID-19.
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MANIFESTAÇÕES GASTROINTESTINAIS DIRETAS E INDIRETAS
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- Authors
- Zeng, W., Qi, K., Ye, M., Zheng, L., Liu, X., Hu, S., Zhang, W., Tang, W., Xu, J., Yu, D., & Wei, Y.
- Affiliations
- Second Affiliated Hospital of Nanchang University (CN)
- Nanchang University (CN)
- Department of Gastroenterology Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang, China
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- Corresponding author
- Zeng, Weibiao
- Qi, Kai
- Ye, Miao
- ORCID
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2021-01-18
- Volume
- 34
- Issue
- 2
- Pages
- 168-176
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W4226084548
- Cited by
- 52
- References
- 57
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 21 · 2022: 16 · 2021: 5
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Dermatology › Dermatological and COVID-19 studies
- Keywords
- COVID-19 pandemic, gastrointestinal symptoms, disease severity, diarrhea, abdominal pain, nausea, vomiting, risk factors
- MeSH terms
- COVID-19, SARS-CoV-2, Gastrointestinal Diseases, Humans, Vomiting, Prevalence
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