The DOI matches its Crossref record.
Epidemiology of drug-induced liver injury in China: a systematic analysis of the Chinese literature including 21,789 patients
Abstract
Background The epidemiology of drug-induced liver injury (DILI) in China has rarely been studied before. The aim of the present study was to determine the etiology of DILI in a Chinese population by reporting a systematic analysis of the Chinese literature published from 1994 to 2011. Methods A comprehensive database search of the Chinese literature was performed to obtain all the relevant studies. The data, including the drug names and patients' sex, age, clinical classification, and prognosis, were collected and analyzed. Results In this research, we found 279 studies including 24 112 patients. There were 265 studies that reported the sex of 21 789 patients, 11 787 men and 10 002 women. The therapeutics included (but were not limited to) tuberculostatics, complementary and alternative medicines (CAMs), antibiotics, NSAIDs, antineoplastics, central nervous system agents, antithyroid drugs, and immunomodulators. Of these drugs, tuberculostatics and CAMs were the most common etiologies of DILI in China. Conclusion DILI in China has a different etiology from that in Europe and USA. NSAIDs, which are the most common causes of DILI in western populations, are uncommon in China. Therefore, government, physicians, and patients should pay more attention to these drugs in DILI.
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Valid epidemiology data of HILI are not available for the population in China.
“In particular, valid epidemiology data of HILI are not available for the population; although, herbal TCMs are integral constituents of the Chinese health system.”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [78]
The respective cohorts in the 2019 Gastroenterology report were grouped under DILI and included liver injury cases caused by herbal TCM and herbal dietary supplements, not allowing for characterization of HILI epidemiology features.
“However, the respective cohorts were grouped under the term of DILI, and represented still not only DILI but also liver injury cases caused by herbal TCM and herbal dietary supplements, representing two different product categories and again providing conditions similar to the shortcomings of the earlier study78 and not allowing for characterization of HILI epidemiology features.36”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [78]
An earlier vain epidemiology analysis was not RUCAM-based and used mixed cohorts of injury cases by drugs, herbs, or CAMs.
“An earlier vain epidemiology analysis was not RUCAM-based and used mixed cohorts of injury cases by drugs, herbs, or CAMs.78”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [78]
Epidemiological data on DILI from medical centers across mainland China have not been available.
“To date, epidemiological data on DILI from medical centers across mainland China have not been available.”
From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [12]
Females have been reported to have increased, unchanged, or even decreased incidence of DILI.
“females have been reported to have increased, 8,26,27,31 unchanged, 9,30 or even decreased 12,21 incidence of DILI (Table 4).”
From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [12]
In China, the proportion of HMs as cause of DILI has been reported to be approximately 20-30%.
“In China, this proportion has been reported to be approximately 20-30% [118-120].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [119]
In China, AT-DILI accounted for 22-31.3% of the investigated cases of DILI.
“In China, AT-DILI accounted for 22-31.3% of the investigated cases of DILI [119].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [119]
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Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 924
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., Xu, J., Niu, J., Liu, J., Watkins, P. B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.002 · Cited by 615
Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
García-Cortés, M., Robles-Díaz, M., Ortega-Alonso, A., Medina-Caliz, I., & Andrade, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040537 · Cited by 179
Björnsson, H. K., Björnsson, E. S., Avula, B., Khan, I. A., Jonasson, J. G., Ghabril, M., Hayashi, P. H., & Navarro, V. (2020) · Liver International · doi:10.1111/liv.14393 · Cited by 125
Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update
Mao, Y., Ma, S., Liu, C., Liu, X., Su, M., Li, D., Li, Y., Chen, G., Chen, J., Chen, J., et al. (2024) · Hepatology International · doi:10.1007/s12072-023-10633-7 · Cited by 62
Teschke, R., Zhu, Y., & Jing, J. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00009 · Cited by 41
Liu, Y., Zhan, S.-P., Song, L., Chen, Y., Jia, Y.-T., Liu, F., Sun, F.-J., Wang, Q., & Xia, P.-Y. (2020) · Medical Science Monitor · doi:10.12659/msm.919435 · Cited by 6
Metadata
- Authors
- Zhou, Y., Yang, L., Liao, Z., He, X., Zhou, Y., & Guo, H.
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2013-07
- Volume
- 25
- Issue
- 7
- Pages
- 825-829
- ISSN
- 0954-691X
- Cited by
- 107
- References
- 0
- Language
- en
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