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Cited by 64Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeDiverticular Disease and Complications

Mortality Trends in Crohnʼs Disease and Ulcerative Colitis: A Population-based Study in Québec, Canada

Bitton, Alain, Vutcovici, Maria, Sewitch, Maida, Suissa, Samy, Brassard, Paul·2016·Inflammatory Bowel Diseases
DOI 10.1097/mib.0000000000000608
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Abstract

BACKGROUND: Mortality rates greater than in the general population have been reported in the population with Crohn's disease (CD), but reports for ulcerative colitis (UC) are conflicting. Trends with time were rarely described. We aimed to assess whether CD and UC mortality in Québec differs from that in the general population and to describe the trends over a 10-year observation period. METHODS: This is a population-based cohort study using the Québec administrative health databases and death certificates registry. All-cause and cause-specific standardized mortality ratios (SMRs) were computed for 1999 to 2008. A time trend analysis was used to assess changes in the SMR with the calendar year. RESULTS: All-cause mortality was significantly increased in CD and UC compared to the general population: SMR: CD 1.45 (95% confidence interval: 1.34-1.58), UC 1.21 (95% confidence interval: 1.12-1.32). In CD, mortality from digestive conditions, all neoplasms, digestive neoplasms, and colorectal, lymphatic, and lung cancer was significantly higher than in the general population. In UC, mortality from digestive, respiratory, and infectious conditions was also significantly increased. In both CD and UC, there was a decrease with time in all-cause SMRs and in digestive conditions, digestive neoplasms, colorectal cancer, and infectious diseases. SMRs for lung cancer and respiratory conditions increased over time in CD. CONCLUSIONS: All-cause mortality was significantly higher in CD and UC populations than in the general population. However, a decreasing trend with time was observed in all-cause and some cause-specific SMRs. In CD, SMRs for lung cancer and respiratory conditions increased during the observation period.

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  • Since IBD has no cure and mortality is relatively low, patients diagnosed at a young age may live for many years.

    “Without a cure, and owing to relatively low mortality, patients with IBD diagnosed at a young age can live a long life63.”

    From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [63]

  • The ageing IBD population will have shorter life expectancy from age-related comorbidities and a slightly higher death risk than age-matched controls without IBD.

    “The ageing IBD population will have reduced life expectancy from age-related comorbidities such as cardiovascular disease and cancer, as well as a small increased risk of death of patients with IBD as compared with age-matched individuals without IBD as controls63,76.”

    From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [63]

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Authors
Bitton, A., Vutcovici, M., Sewitch, M., Suissa, S., & Brassard, P.
Affiliations
  • McGill University Health Centre (CA)
  • Jewish General Hospital (CA)
Corresponding author
Bitton, Alain
ORCID
Venue
Inflammatory Bowel Diseases
Publisher
Oxford University Press (OUP)
Published
2016-02
Volume
22
Issue
2
Pages
416-423
ISSN
1078-0998 (ISSN-L)
DOI
10.1097/mib.0000000000000608
OpenAlex
W1803773569
Cited by
64
References
54
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 1 · 2016: 3
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Locations
  • Inflammatory Bowel Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
Keywords
Crohn's disease, ulcerative colitis
MeSH terms
Adolescent, Adult, Aged, Canada, Child, Child, Preschool, Colitis, Ulcerative, Crohn Disease, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mortality, Prognosis, Quebec, Young Adult

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