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Cited by 72Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeDiverticular Disease and Complications

Predictors and risks for death in a population-based study of persons with IBD in Manitoba

Bernstein, Charles N, Nugent, Zoann, Targownik, Laura E, Singh, Harminder, Lix, Lisa M·2015·Gut
DOI 10.1136/gutjnl-2014-307983
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Abstract

Background and aims: We aimed to determine the predictors and risk for death among persons with either Crohn's disease (CD) or UC compared with the general population. Methods: We used the population-based University of Manitoba IBD Epidemiology Database to calculate HRs and their 95% CIs for cases relative to controls using stratified multivariable Cox proportional hazards regression models, controlling for socioeconomic status and comorbidities. Results: There were 10 788 prevalent cases of CD and UC and 101 860 matched controls. The HR for all-cause mortality in prevalent CD cases was 1.26 (95% CI 1.16 to 1.38) and in prevalent UC cases was 1.04 (95% CI 0.96 to 1.12). Compared with matched controls, CD cases were more likely to die of colorectal cancer, non-Hodgkin's lymphoma, digestive diseases, pulmonary embolism and sepsis and UC cases were more likely to die from colorectal cancer, digestive diseases and respiratory diseases. For incident cases, there were significant effects on mortality by socioeconomic status, comorbidity score and surgery. The greatest risk for death in both CD and UC was within the first 30 days following GI surgery. The first year from diagnosis was associated with increased risk of death in both CD and UC, but persisted after the 1st year only in CD. Conclusions: There is a significantly increased risk of mortality in CD compared with controls while in UC an increased risk for death was only evident in the first year from diagnosis. Surgery poses an increased risk for death in both CD and UC lasting up to 1 year.

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  • The ageing IBD population will have shorter life expectancy from age-related comorbidities and a slightly higher death risk than age-matched controls without IBD.

    “The ageing IBD population will have reduced life expectancy from age-related comorbidities such as cardiovascular disease and cancer, as well as a small increased risk of death of patients with IBD as compared with age-matched individuals without IBD as controls63,76.”

    From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [76]

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Authors
Bernstein, C. N., Nugent, Z., Targownik, L. E., Singh, H., & Lix, L. M.
Affiliations
  • University of Manitoba (CA)
  • CancerCare Manitoba (CA)
Corresponding author
Bernstein, Charles N
ORCID
Venue
Gut
Publisher
BMJ
Published
2014-09-16
Volume
64
Issue
9
Pages
1403-1411
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gutjnl-2014-307983
OpenAlex
W2151351996
Cited by
72
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 11 · 2015: 6
FWCI
4.37
Type
journal article
Language
en
Open access
closed
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, mortality, all-cause mortality, colorectal cancer, non-Hodgkin lymphoma, gastrointestinal surgery, postoperative mortality, socioeconomic status, comorbidities, risk factors
MeSH terms
Cause of Death, Colitis, Ulcerative, Crohn Disease, Female, Hospitals, University, Humans, Male, Manitoba, Predictive Value of Tests, Severity of Illness Index, Inflammatory Bowel Diseases, Confidence Intervals, Proportional Hazards Models, Survival Analysis, Case-Control Studies, Databases, Factual, Age Distribution, Sex Distribution, Risk Assessment, Kaplan-Meier Estimate

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