Cited by 112Atrial Fibrillation Management and OutcomesRenin-Angiotensin System StudiesCardiac electrophysiology and arrhythmias

Prevention of atrial fibrillation by way of abrogation of the renin-angiotensin system: a systematic review and meta-analysis

Jibrini, Mhamad B, Molnar, Janos, Arora, Rohit R·2008·American Journal of Therapeutics

Abstract

The renin-angiotensin-aldosterone system (RAAS) has emerged as an important hormonal system in the initiation and pathogenesis of atrial fibrillation (AF). Therefore, angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) are emerging as novel drugs for the prevention of AF. A meta-analysis of 11 randomized, controlled, parallel-design clinical trials evaluating effect of ACEIs or ARBs on the development of AF was performed. Treatment with ACEIs or ARBs reduced the relative risk (RR) of AF in patients with hypertension by 23% [RR 0.769, P < 0.001, 95% confidence interval (CI) 0.686-0.862] and by 11% in patients after myocardial infarction (RR 0.898, P < 0.05, 95% CI 0.814-0.992). Reduction in AF was greatest in patients after electrical cardioversion (RR 0.491, P < 0.001, 95% CI 0.334-0.720) and in patients with heart failure (RR 0.684, P < 0.001, 95% CI 0.594-0.787). Overall, inhibition of the RAAS reduced the RR of AF by 19% (RR 0.810, P < 0.001, 95% CI 0.759-0.865).

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Crossref · 10.1097/mjt.0b013e31804beb59

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Authors
Jibrini, M. B., Molnar, J., & Arora, R. R.
Affiliations
American College of Cardiology (US)
Venue
American Journal of Therapeutics
Published
2008-01
Volume
15
Issue
1
Pages
36-43
ISSN
1075-2765 (ISSN-L)
OpenAlex
W2159776801
Cited by
111
References
43
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 7
FWCI
2.29
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
atrial fibrillation, renin-angiotensin-aldosterone system, ACE inhibitors, angiotensin receptor blockers, atrial fibrillation prevention, hypertension, myocardial infarction, electrical cardioversion, heart failure
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Atrial Fibrillation, Electric Countershock, Heart Failure, Humans, Hypertension, Myocardial Infarction, Renin-Angiotensin System, Risk Factors, Randomized Controlled Trials as Topic, Angiotensin II Type 1 Receptor Blockers

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