Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, Grant R.; Sobey, Christopher G.

doi:10.1016/j.tem.2014.06.012

Cited by 315Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, Grant R., Sobey, Christopher G.·2014·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2014.06.012

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Abstract

NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated in the pathophysiology of vascular diseases such as hypertension and stroke. Endothelial cells express four NOX isoforms including the superoxide-generating enzymes NOX1, NOX2, and NOX5 and the hydrogen peroxide-generating enzyme NOX4. Studies on arteries from patients with coronary artery disease, and in animals with experimentally induced hypertension, diabetes, or atherosclerosis, suggest that NOX1, NOX2, and NOX5 promote endothelial dysfunction, inflammation, and apoptosis in the vessel wall, whereas NOX4 is by contrast vasoprotective in increasing nitric oxide bioavailability and suppressing cell death pathways. Based on these findings and promising preclinical studies with the NOX1/NOX2 antagonist, apocynin, we suggest that the field is poised for clinical evaluation of NOX inhibitors as therapeutics for cardiovascular disease.

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In the human vasculature, the most relevant NOX isoforms appear to be NOX1, NOX2, NOX4, and NOX5.
“In the human vasculature, the most relevant isoforms appear to be NOX1, NOX2, NOX4, and NOX5 (252, 253, 555).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [253]
Mice combining the mutation of p47phox−/− with ApoE−/− appear to be protected from atherosclerotic lesions compared with ApoE−/− mice.
“The mice combining the mutation of p47phox−/− with ApoE−/− appear to be protected from atherosclerotic lesions (253) compared with ApoE−/− mice (64, 976), although some reports do not find significant differences in atherosclerosis progression or lesion size (443).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [253]
NOX4 protective role may be due to its generation of hydrogen peroxide, and not superoxide.
“NOX4 protective role may be due to its generation of hydrogen peroxide, and not superoxide (253).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [253]

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Authors: Drummond, G. R., & Sobey, C. G.
Affiliations: Monash Medical Centre (AU)
ORCID: Drummond, Grant R.
Sobey, Christopher G.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2014-09
Volume: 25
Issue: 9
Pages: 452-463
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2014.06.012
OpenAlex: W1969643223
Cited by: 315
References: 132
Citations by year: 2026: 14 · 2025: 15 · 2024: 24 · 2023: 18 · 2022: 33 · 2021: 20 · 2020: 31 · 2019: 28 · 2018: 29 · 2017: 42 · 2016: 39 · 2015: 20 · 2014: 2
FWCI: 4.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, endothelial cells, NOX1, NOX2, NOX4, NADPH oxidase 5, reactive oxygen species, endothelial dysfunction, hypertension, stroke, atherosclerosis, coronary artery disease, apocynin, NOX inhibitors, nitric oxide bioavailability, inflammation, apoptosis
MeSH terms: NADPH Oxidase 1, NADPH Oxidase 2, NADPH Oxidase 4, NADPH Oxidase 5, Animals, Cardiovascular Agents, Endothelium, Vascular, Enzyme Inhibitors, Humans, Membrane Glycoproteins, Membrane Proteins, Mice, Transgenic, Models, Biological, Vascular Diseases, Mice, Knockout, NADPH Oxidases, Molecular Targeted Therapy

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Endothelial NADPH oxidases: which NOX to target in vascular disease?

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