The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Langerhans cell origin and regulation
Open accessAbstract
PURPOSE OF REVIEW: This article summarizes recent research on the ontogeny of Langerhans cells and regulation of their homeostasis in quiescent and inflamed conditions. RECENT FINDINGS: Langerhans cells originate prenatally and may endure throughout life, independently of bone marrow-derived precursors. Fate-mapping experiments have recently resolved the relative contribution of primitive yolk sac and fetal liver hematopoiesis to the initial formation of Langerhans cells. In postnatal life, local self-renewal restores Langerhans cell numbers following chronic or low-grade inflammatory insults. However, severe inflammation recruits de-novo bone marrow-derived precursors in two waves; a transient population of classical monocytes followed by uncharacterized myeloid precursors that form a stable self-renewing Langerhans cell network as inflammation subsides. Human CD1c⁺ dendritic cells have Langerhans cell potential in vitro, raising the possibility that dendritic cell progenitors provide the second wave. Langerhans cell development depends upon transforming growth factor beta receptor signaling with distinct pathways active during differentiation and homeostasis. Langerhans cell survival is mediated by multiple pathways including mechanistic target of rapamycin and extracellular signal-regulated kinase signaling, mechanisms that become highly relevant in Langerhans cell neoplasia. SUMMARY: The study of Langerhans cells continues to provide novel and unexpected insights into the origin and regulation of myeloid cell populations. The melding of macrophage and dendritic cell biology, shaped by a unique habitat, is a special feature of Langerhans cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Langerhans cells are a unique cell population to the skin organ, where fate‐mapping of macrophages demonstrates in situ proliferation to Langerhans cells in the skin during embryonic development.[ 78 , 79 , 80 , 81 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [78]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Mechanistically, this is driven by interleukin‐34 release via macrophage‐colony stimulating factor receptor.[ 78 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [78]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Notably, this observation aligns with previous studies that mature human SKOs resemble human fetal craniofacial skin at 18‐week of gestation.[ 26 , 78 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [78]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135
van Furth, R., Cohn, Z. A., Jg, H., Humphrey, J., Spector, W. G., & Langevoort, H. L. (1972) · PubMed Central · Cited by 1,133
Langerhans cells renew in the skin throughout life under steady-state conditions
Mérad, M., Manz, M. G., Karsunky, H., Wagers, A. J., Peters, W., Charo, I. F., Weissman, I. L., Cyster, J. G., & Engleman, E. G. (2002) · Nature Immunology · doi:10.1038/ni852 · Cited by 1,023
Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011
Research works printed but not linked: 3
- van Furth, 1972, Bull World Health Organ, 46, 845
- Merad, 2002, Nat Immunol, 31, 135
- Hieronymus, 2015, iol, 41, 30
Cited by
Sorted by citations
Human dendritic cell subsets: an update
Collin, M., & Bigley, V. (2018) · Immunology · doi:10.1111/imm.12888 · Cited by 1,301
Self-citationMicroneedle-Based Delivery: An Overview of Current Applications and Trends
Guillot, A. J., Cordeiro, A. S., Donnelly, R. F., Montesinos, M. C., Garrigues, T., & Melero, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060569 · Cited by 262
Metabolic Control of Dendritic Cell Functions: Digesting Information
Wculek, S. K., Khouili, S. C., Priego, E., Heras‐Murillo, I., & Sancho, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00775 · Cited by 218
The role of the microbiome in scalp hair follicle biology and disease
Polak‐Witka, K., Rudnicka, L., Blume‐Peytavi, U., & Vogt, A. (2019) · Experimental Dermatology · doi:10.1111/exd.13935 · Cited by 157
Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., et al. (2018) · eLife · doi:10.7554/elife.41258 · Cited by 120
Identification of HIV transmitting CD11c+ human epidermal dendritic cells
Bertram, K. M., Botting, R. A., Baharlou, H., Rhodes, J. W., Rana, H., Graham, J. D., Patrick, E., Fletcher, J., Plasto, T. M., Truong, N. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10697-w · Cited by 115
Immunogenicity Challenges Associated with Subcutaneous Delivery of Therapeutic Proteins
Jarvi, N. L., & Balu‐Iyer, S. V. (2021) · BioDrugs · doi:10.1007/s40259-020-00465-4 · Cited by 105
Border-associated macrophages in the central nervous system
Sun, R., & Jiang, H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03059-x · Cited by 120
van Dinther, D., Stolk, D. A., van de Ven, R., van Kooyk, Y., de Gruijl, T. D., & den Haan, J. M. M. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0217-059rr · Cited by 88
Fischer, R. S., Lam, P., Anna Huttenlocher, A., & Waterman, C. M. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.08.015 · Cited by 79
Advances in the polymeric delivery of nucleic acid vaccines
Chen, G., Zhao, B., Ruiz, E. F., & Zhang, F. (2022) · Theranostics · doi:10.7150/thno.70853 · Cited by 76
Transcriptional control of dendritic cell development and functions
Amon, L., Lehmann, C. H. K., Barańska, A., Schoen, J., Heger, L., & Dudziak, D. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.10.001 · Cited by 72
Microbiome and Postbiotics in Skin Health
Prajapati, S. K., Lekkala, L., Yadav, D., Jain, S., & Yadav, H. (2025) · Biomedicines · doi:10.3390/biomedicines13040791 · Cited by 79
Dendritic cells in pregnancy and pregnancy-associated diseases
Wei, R., Lai, N., Zhao, L., Zhang, Z., Zhu, X., Guo, Q., Chu, C., Fu, X., & Li, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110921 · Cited by 66
Zou, D.-D., Sun, Y.-Z., Li, X., Xu, D., Xu, D., He, Y.-T., Qi, J., Tu, Y., Tang, Y., Tu, Y., et al. (2023) · eLife · doi:10.7554/elife.85270 · Cited by 59
Lyadova, I. V., Gerasimova, T., & Nenasheva, T. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640703 · Cited by 56
Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications
Wu, D., Li, T., & Ji, X. (2017) · Journal of Immunology Research · doi:10.1155/2017/3591248 · Cited by 56
Italiani, P., & Boraschi, D. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_2 · Cited by 53
Sengal, A. G., Velazquez, J., Hahne, M., Burke, T. M., Abhyankar, H. A., Reyes, R., Olea, W., Scull, B., Eckstein, O. S., Bigenwald, C., et al. (2020) · Blood · doi:10.1182/blood.2020005867 · Cited by 48
Zhang, M., Li, N., Cai, R., Gu, J., Xie, F., Wei, H., Lu, C., & Wu, D. (2021) · Phytotherapy Research · doi:10.1002/ptr.7155 · Cited by 48
Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons
Wilcox, N. C., Taheri, G., Halievski, K., Talbot, S., Silva, J. R., & Ghasemlou, N. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.03.006 · Cited by 45
Skin Immunity and Tolerance: Focus on Epidermal Keratinocytes Expressing HLA-G
Mestrallet, G., Rouas‐Freiss, N., LeMaoult, J., Fortunel, N. O., & Martin, M. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772516 · Cited by 43
3D skin models in domestic animals
Souci, L., & Denesvre, C. (2021) · Veterinary Research · doi:10.1186/s13567-020-00888-5 · Cited by 52
The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
Yan, B., Liu, N., Li, J., Li, J., Zhu, W., Kuang, Y., Chen, X., & Peng, C. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15834 · Cited by 41
Hashiguchi, Y., Yabe, R., Chung, S.-H., Murayama, M. A., Yoshida, K., Matsuo, K., Kubo, S., Saijo, S., Nakamura, Y., Matsue, H., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701157 · Cited by 41
Human dendritic cell immunodeficiencies
Bigley, V., Cytlak, U., & Collin, M. P. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.02.020 · Cited by 41
Self-citationLangerhans Cells—Revising Their Role in Skin Pathologies
Neagu, M. T., Constantin, C., Jugulete, G., Cauni, V. M., Dubrac, S., Szöllősi, A. G., & Zurac, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12122072 · Cited by 43
Human Skin: Composition, Structure and Visualisation Methods
Graham, H. K., Eckersley, A., Ozols, M., Mellody, K. T., & Sherratt, M. J. (2019) · Studies in mechanobiology, tissue engineering and biomaterials · doi:10.1007/978-3-030-13279-8_1 · Cited by 36
CD207+CD1a+ cells circulate in pediatric patients with active Langerhans cell histiocytosis
Silva, E. A. C., Nowak, W., Tessone, L., Olexen, C. M., Wilczyński, J., Estecho, I. G., Elena, G. O., Errasti, A. E., & Rosso, D. A. (2017) · Blood · doi:10.1182/blood-2017-05-782730 · Cited by 35
Veremeyko, T., Yung, A. W. Y., Dukhinova, M., Strekalova, T. V., & Ponomarev, E. D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00453 · Cited by 35
Israr, M., DeVoti, J. A., Lam, F., Abramson, A. L., Steinberg, B. M., & Bonagura, V. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00336 · Cited by 25
Hashimoto-Hill, S., Friesen, L., Park, S., Im, S., Kaplan, M. H., & Kim, C. H. (2018) · Nature Communications · doi:10.1038/s41467-018-06341-8 · Cited by 24
Skin Development and Disease: A Molecular Perspective
Dermitzakis, I., Chatzi, D., Kyriakoudi, S. A., Evangelidis, N., Vakirlis, E., Meditskou, S., Theotokis, P., & Μanthou, M. E. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080487 · Cited by 28
Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function
Bellmann, L., Zelle‐Rieser, C., Milne, P., Resteu, A., Tripp, C. H., Hermann‐Kleiter, N., Zaderer, V., Wilflingseder, D., Hörtnagl, P., Theochari, M., et al. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.05.098 · Cited by 23
Self-citationZhu, J., Inomata, T., Zazzo, A. D., Kitazawa, K., Okumura, Y., Coassin, M., Surico, P. L., Fujio, K., Yanagawa, A., Miura, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204667 · Cited by 23
Jin, F., Xie, L., Zhang, H., Fan, X., Tian, J., Liu, W., Xiao, Y., & Fan, X. (2025) · MedComm · doi:10.1002/mco2.70455 · Cited by 29
Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis
Piacente, F., Bottero, M., Benzi, A., Vigo, T., Uccelli, A., Bruzzone, S., & Ferrara, G. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084352 · Cited by 21
Micro-environmental signals directing human epidermal Langerhans cell differentiation
Strobl, H., Krump, C., & Borek, I. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.02.016 · Cited by 22
Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis
Gao, X., Li, J., & Cao, X. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00917-0 · Cited by 22
Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes
Egan, C., & Jaffe, E. S. (2017) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2017.11.002 · Cited by 20
Inhibition of IRF8 Negatively Regulates Macrophage Function and Impairs Cutaneous Wound Healing
Guo, Y., Yang, Z., Wu, S., Xu, P., Peng, Y., & Yao, M. (2016) · Inflammation · doi:10.1007/s10753-016-0454-8 · Cited by 19
Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling
Tenno, M., Shiroguchi, K., Muroi, S., Kawakami, E., Koseki, K., Kryukov, K. A., Imanishi, T., Ginhoux, F., & Taniuchi, I. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170729 · Cited by 19
Manipulation of Mononuclear Phagocytes by HIV: Implications for Early Transmission Events
Bertram, K. M., Tong, O., Royle, C. M., Turville, S. G., Nasr, N., Cunningham, A. L., & Harman, A. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02263 · Cited by 20
Mostina, M., Sun, J., Sim, S. L., Ahmed, I. A., Souza‐Fonesca‐Guimaraes, F., Wolvetang, E. J., Brown, J., Kumari, S., Khosrotehrani, K., & Shafiee, A. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502108 · Cited by 17
Nikolić, N., Kienzl, P., Tajpara, P., Vierhapper, M. F., Matiasek, J., & Elbe‐Bürger, A. (2019) · Journal of Immunology Research · doi:10.1155/2019/5143635 · Cited by 17
Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential
Toriyama, M., & Ishii, K. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.621318 · Cited by 16
Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling
Donati, V., Peres, C., Nardin, C., Scavizzi, F., Raspa, M., Ciubotaru, C. D., Bortolozzi, M., Pedersen, M. G., & Mammano, F. (2021) · Function · doi:10.1093/function/zqab064 · Cited by 15
Czyz, C. M., Kunth, P. W., Грубер, Ф., Kremslehner, C., Hammers, C. M., & Hundt, J. E. (2023) · Experimental Dermatology · doi:10.1111/exd.14911 · Cited by 19
Li, S., Jin, X., Ge, X., Zuo, Y., & Jin, H. (2020) · Journal of Immunology Research · doi:10.1155/2020/4594630 · Cited by 16
Maina, J. N. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13000 · Cited by 14
Hu, X., Buhl, C. S., Sjogaard, M. B., Schousboe, K., Mizrak, H. I., Kufaishi, H., Hansen, C. S., Yderstræde, K. B., Jensen, T. S., Nyengaard, J. R., et al. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200144 · Cited by 13
Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy
Mahajan, D., Kumar, T., Rath, P. K., Sahoo, A. K., Mishra, B. P., Kumar, S., Nayak, N. R., & Jena, M. K. (2024) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.2478/aite-2024-0010 · Cited by 14
Kumar, M. (2024) · Wiley eBooks · doi:10.1002/9781119933861.ch1 · Cited by 16
Buffa, D. J., O’Neil, T. R., Vine, E. E., Sarkawt, L., van Dijk, F. A. W., Dong, O. A., Nasr, N., Cunningham, A. L., Bertram, K. M., & Harman, A. N. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013490 · Cited by 13
Peil, J., Bock, F., Kiefer, F., Schmidt, R., Heindl, L. M., Cursiefen, C., & Schlereth, S. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031478 · Cited by 12
Polak, M. E., & Singh, H. (2021) · BioEssays · doi:10.1002/bies.202000182 · Cited by 11
Solhaug, M. B., Schreurs, O., Schenck, K., Blix, I. J. S., & Bækkevold, E. S. (2021) · European Journal Of Oral Sciences · doi:10.1111/eos.12835 · Cited by 10
Tethering Innate Surface Receptors on Dendritic Cells: A New Avenue for Immune Tolerance Induction?
Lamendour, L., Deluce, N. K.-N., Mouline, C. C., Gouilleux‐Gruart, V., & Velge-Roussel, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155259 · Cited by 10
Zyulina, V., Yan, K., Ju, B., Schwarzenberger, E., Passegger, C. A., Tam‐Amersdorfer, C., Pan, Q., Sconocchia, T., Pollack, C., Shaner, B., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109049 · Cited by 9
Monitoring Circulating CD207+CD1a+ Cells in Langerhans Cell Histiocytosis and Clinical Implications
Olexen, C. M., Rosso, D. A., Nowak, W., Fortunati, D., Errasti, A. E., & Silva, E. A. C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200147 · Cited by 9
Pejčić, A., Andjelkovic, Z., Marjanovic, D., Minić, I., Matvijenko, V., Arsic, Z., Jovanović, R., & Subaric, L. (2023) · Journal of Clinical Pathology · doi:10.1136/jcp-2021-207975 · Cited by 7
The current understanding on langerhans' cells and its role in oral lesions
Chandavarkar, V., Mishra, M., Sangeetha, R., & Premalatha, B. R. (2020) · Contemporary Clinical Dentistry · doi:10.4103/ccd.ccd_4_20 · Cited by 7
Langerhans cell histiocytosis in adults: literature review
Потапенко, В. Г., Baykov, V. V., Zinchenko, A. V., & Александровна, П. Н. (2022) · Oncohematology · doi:10.17650/1818-8346-2022-17-4-16-32 · Cited by 7
Innate Immunity and Platelets: Unveiling Their Role in Chronic Pancreatitis and Pancreatic Cancer
Blümke, J., Schameitat, M., Verma, A., Limbecker, C., Arlt, E., Kessler, S. M., Kielstein, H., Krug, S., Bazwinsky‐Wutschke, I., & Hämmerle, M. (2025) · Cancers · doi:10.3390/cancers17101689 · Cited by 7
Microneedle for wound healing and dermal application
Kumar, M., Mahmood, S., Hilles, A. R., & Bhatia, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13881-2.00008-4 · Cited by 6
Yashige, K., Kataoka, T. R., Yamada, Y., Maeda, H., Tsujimura, M., Yamamoto, T., Takei, Y., Moriyoshi, K., Ōno, K., Kaku, Y., et al. (2021) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.255.27 · Cited by 5
Robinson, H., Jarrett, P., Vedhara, K., Tarlton, J. F., Whiting, C. V., Law, M., & Broadbent, E. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.110987 · Cited by 5
Isolated Langerhans cell histiocytosis of the spleen
Hong, L., Sun, G., Peng, L., Tu, Y., Li, Y., & Xiao, W. (2018) · Medicine · doi:10.1097/md.0000000000012378 · Cited by 5
Finding active LCH cells in the blood
Abla, O. (2017) · Blood · doi:10.1182/blood-2017-09-805424 · Cited by 4
AZUMA, H., Watanabe, E., OTSUKA, Y., Negishi, Y., Ohkura, S., Shinya, E., & Takahashi, H. (2016) · Biomedical Research · doi:10.2220/biomedres.37.271 · Cited by 4
Seth, N., Abeykoon, J. P., Goyal, G., Go, R. S., Tessier, S., King, R. L., & Ravindran, A. (2025) · Cancers · doi:10.3390/cancers17122055 · Cited by 3
Tan, Y. F., Yeh, C.-Y., Hsu, S.-Y., Lu, C., Tsai, C., Chiang, P., Weng, H.-J., Tsai, T., & Lee, Y. L. (2025) · Nature Communications · doi:10.1038/s41467-025-63971-5 · Cited by 5
de França, G. M., Felipe, J., FREITAS, C. T. S. D., de Lucena, H. F., de Andrade, A. L. D. L., & Galvão, H. C. (2021) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000919 · Cited by 3
Dissolving Microneedles Drug Delivery System: A Comprehensive Review
Bairagi, A., Jain, A., & Singhai, A. K. (2024) · Research Journal of Pharmaceutical Dosage Forms and Technology · doi:10.52711/0975-4377.2024.00042 · Cited by 2
Role of dendritic cells in maintenance of the skin structural homeostasis.
Aliyeva, O. G., & Sulaieva, O. (2016) · Morphologia · doi:10.26641/1997-9665.2016.3.14-18 · Cited by 2
Evaluating Macrophages in Immunotoxicity Testing
Franko, J., McCall, J. L., & Barnett, J. B. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8549-4_17 · Cited by 2
Qureshi, A., Al-Khabori, M. K., Haddabi, I. H. A., Qureshi, H., & Jawa, Z. M. (2023) · International Journal of Surgical Pathology · doi:10.1177/10668969231206571 · Cited by 2
Langerhans cell histiocytosis developing acute lymphoblastic leukemia
Zhang, J., Zong, S., & Liao, B. (2022) · SAGE Open Medical Case Reports · doi:10.1177/2050313x221080328 · Cited by 2
Sirotnikov, S., Dehner, L. P., Vega, J. E. V., & Cheng, J. (2024) · Pediatric and Developmental Pathology · doi:10.1177/10935266241281517 · Cited by 1
Histiocytes: Multifaceted Regulators of Health and Disease
Gruber, E. J. (2025) · Veterinary Clinical Pathology · doi:10.1111/vcp.70065 · Cited by 1
Structure and Development of the Skin and Cutaneous Appendages
Chu, D. H., & Loomis, C. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00048-2 · Cited by 1
Nanophytomedicines: a novel approach for improving therapeutics via delivery of herbal medicine
Bakrim, S., Balahbib, A., Mrabti, H. N., Ghchime, R., Omari, N. E., & Bouyahya, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85785-7.00011-5 · Cited by 1
Film Forming Nanogels for Needle‐Free Transdermal Vaccination
Sonzogni, A. S., Cabrera, G., Lupi, G., Gugliotta, L. M., Gonzalez, V., Marcipar, I. S., & Minari, R. J. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202100515 · Cited by 1
Case 26-2022: A 48-Year-Old Woman with Cystic Lung Disease
Reddy, K. P., Price, M. C., Barnes, J. A., Rigotti, N. A., & Crotty, R. K. (2022) · New England Journal of Medicine · doi:10.1056/nejmcpc2201247 · Cited by 2
Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cellsPreprint
Polak, M. E., Sirvent, S., Clayton, K., Davies, J., Vallejo, A. F., Wu, Z., Woo, J., Riddell, J., Stumpf, P. S., Rose-Zerilli, M. J. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/541383 · Cited by 1
Calcium signaling in the photodamaged skinPreprint
Donati, V., Peres, C., Nardin, C., Scavizzi, F., Raspa, M., Ciubotaru, C. D., Bortolozzi, M., & Mammano, F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.443726 · Cited by 1
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-39255-6.50251-9
Säwén, P. (2017) · Lund University Publications (Lund University)
An insight into the origin, distribution, and techniques of demonstration of Langerhans cells
Snehanjan, S., & Aich, R. (2017) · SRM Journal of Research in Dental Sciences · doi:10.4103/srmjrds.srmjrds_33_17
Zyulina, V., Yan, K., Ju, B., Passegger, C. A., Tam‐Amersdorfer, C., Pan, Q., Sconocchia, T., Pollack, C., Shaner, B., Zebisch, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.07.285627
Rhodes, J. W. (2020) · The Sydney eScholarship Repository (The University of Sydney)
Liu, R. (2020) · Open Access Journal of Biomedical Science · doi:10.38125/oajbs.000214
Macrophage Surveillance and Immunity: Eating, Drinking, and Digesting
Ostrowski, P. P. (2020) · TSpace (University of Toronto)
Distribuição das células dendríticas em sarcoma de Kaposi oral associado à AIDS
de CÁCERES, C. V. B. L. (2017) · doi:10.47749/t/unicamp.2017.994725
Naeim, F., Rao, P. N., Song, S. X., & Phan, R. T. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-809843-1.00062-0
Vidales, L. Y. G., & Valbuena, M. C. (2023) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.1680
Histiocytic and dendritic cell disorders
Naeim, F., Rao, P. N., & Song, S. X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18838-1.00030-x
The Hematopoietic System: Evaluation and Data Interpretation in Nonclinical Safety Studies
Naor, A. W., & Ramaiah, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00180-7
Metadata
- Authors
- Collin, M., & Milne, P.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Collin, Matthew
- Venue
- Current Opinion in Hematology
- Published
- 2016-01
- Volume
- 23
- Issue
- 1
- Pages
- 28-35
- ISSN
- 1065-6251 (ISSN-L)
- PMC
- PMC4685746
- OpenAlex
- W2409593987
- Cited by
- 120
- References
- 65
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 16 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Hematology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Histiocytosis Association
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Hematology › Histiocytic Disorders and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- Langerhans cells, fetal liver hematopoiesis, yolk sac hematopoiesis, self-renewal, inflammation, classical monocytes, myeloid precursors, CD1c+ dendritic cells, dendritic cell progenitors, mTOR signaling, ERK signaling, myeloid cell development
- MeSH terms
- Cell Self Renewal, Animals, Cell Differentiation, Fetus, Histiocytosis, Langerhans-Cell, Homeostasis, Humans, Inflammation, Langerhans Cells, Liver, Macrophages, Monocytes, Stem Cells, Yolk Sac, Cell Lineage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
