Macrophage heterogeneity in atherosclerotic plaques

Johnson, Jason L; Newby, Andrew C

doi:10.1097/mol.0b013e3283309848

Cited by 183Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismImmune cells in cancer

Macrophage heterogeneity in atherosclerotic plaques

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Johnson, Jason L, Newby, Andrew C·2009·Current Opinion in Lipidology

DOI 10.1097/mol.0b013e3283309848PMC PMC2850554

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Abstract

PURPOSE OF REVIEW: The varied behaviour of macrophages and foam cells during atherosclerosis and its clinical sequelae prompt the question whether all these activities can be the property of a single cell population. RECENT FINDINGS: Subsets of monocytes with distinct patterns of surface markers and behaviours during inflammation have recently been characterized and shown to have complementary roles during progression of atherosclerosis. A variety of macrophage phenotypes derived from these monocyte subsets in response to mediators of innate and acquired immunity have also been found in plaques. Based on functional properties and genomic signatures, they may have different impacts on facets of plaque development, including fibrous cap and lipid core formation. SUMMARY: Monocyte and macrophage phenotypic diversity is important in atherogenesis. More work is needed to define consistent marker sets for the different foam cell phenotypes in experimental animals and humans. Cell tracking studies are needed to establish their relationship with monocyte subtypes. In addition, genetic and pharmacological manipulation of phenotypes will be useful to define their functions and exploit the resulting therapeutic potential.

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A macrophage phenotypic switch occurs with atherosclerosis progression.
“Also similar to cancer, a macrophage phenotypic switch is observed to occur with disease progression, albeit with significantly different pathologic sequelae [45–48].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [45]
Initial infiltrating macrophage population in early atherosclerosis is heterogeneous but predominantly M2-like.
“A number of recent studies have begun to assess the polarization profile of plaque infiltrating macrophages, suggesting that the initial infiltrating population in early atherosclerosis is heterogeneous, but possesses a predominantly M2-like phenotype [28,45].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [45]
Atherosclerosis etiology includes inflammatory cells, particularly macrophages.
“Similar to cancer, atherosclerosis has an etiology that has, for many years, been recognized to include the involvement an inflammatory cell population, in particular macrophages [45–47].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [45]

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Self-citation

Authors: Johnson, J. L., & Newby, A. C.
Affiliations: Bristol Royal Infirmary (GB)
Corresponding author: Newby, Andrew C
ORCID: Johnson, Jason L
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-10
Volume: 20
Issue: 5
Pages: 370-378
ISSN: 0957-9672 (ISSN-L)
DOI: 10.1097/mol.0b013e3283309848
PMC: PMC2850554
OpenAlex: W1965293055
Cited by: 183
References: 61
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 19 · 2014: 21 · 2013: 16 · 2012: 27
FWCI: 1.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Opinion in Lipidology (publishedVersion)
Bristol Research (University of Bristol) (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Explore Bristol Research (submittedVersion)
Funders: British Heart Foundation (FS/07/053/24069, RG/09/006/27918)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: macrophage heterogeneity, atherosclerosis, foam cells, monocyte subsets, macrophage phenotype, atherogenesis, cell surface markers, innate and adaptive immunity, cell tracking
MeSH terms: Animals, Humans, Inflammation, Macrophages, Monocytes, Phenotype, Atherosclerosis

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Macrophage heterogeneity in atherosclerotic plaques

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