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Cited by 386Effects and risks of endocrine disrupting chemicalsPesticide Exposure and ToxicityToxic Organic Pollutants Impact

Phthalate exposure and children's health

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Braun, Joseph M., Sathyanarayana, Sheela, Hauser, Russ·2013·Current Opinion in Pediatrics
DOI 10.1097/mop.0b013e32835e1eb6PMC PMC3747651
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Abstract

PURPOSE OF REVIEW: Phthalates are multifunctional chemicals used in personal care products, medications, and plastics. We reviewed the epidemiological literature examining the relationship between early life phthalate exposure and pediatric health outcomes. RECENT FINDINGS: Five studies from Asia, Europe, and the United States suggest that childhood exposure to di-2-ethylhexyl phthalate (DEHP) and butylbenzyl phthalate (BBzP) may increase the risk of allergic diseases including asthma and eczema. Six studies from four different prospective cohorts report that gestational BBzP, DEHP, di-butyl phthalate (DBP), and di-ethyl phthalate (DEP) exposures are associated with alterations in infant/toddler physical development as well as parent-reported externalizing, internalizing, and autistic-like child behavior. However, there are inconsistencies related to the specific phthalates and behavioral domains. Two small studies report shorter anogenital distance among male infants with higher gestational phthalate exposure. SUMMARY: Several epidemiological studies suggest fetal and childhood exposure to some phthalates may perturb normal development, with several studies consistently reporting increased risk of allergic diseases with DEHP and BBzP exposure. Although anticipatory guidance is not evidence-based at this time, providers can counsel concerned patients to reduce phthalate exposures in order to protect the developing fetus and child from potential adverse health outcomes.

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  • DEHP and BzBP and their monoesters are regarded as allergens, and exposure to them has been associated with asthma and wheezing in adults.

    “DEHP and BzBP and their monoesters are regarded as allergens, and exposure to them has been associated with asthma and wheezing in adults [200,201].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [200]

    The “Asthma and Allergy” section reports associations between DEHP and BBzP exposure and asthma or wheezing in children, not adults. It describes phthalates as potential adjuvants affecting allergen response, but does not classify DEHP, BBzP, or their monoesters as allergens. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Exposure of DEHP, BzBP, DBP, and DEP during gestation has been associated with allergic responses in infants and toddlers.

    “Exposure of DEHP, BzBP, DBP, and DEP during gestation has been associated with allergic responses in infants and toddlers [200].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [200]

    The Asthma and Allergy section reports that maternal BBzP exposure during pregnancy was associated with eczema appearing by 24 months. It links DEHP chiefly to childhood exposure and allergic disease; it does not report gestational DEHP, DBP, or DEP exposure as associated with allergic responses in infants or toddlers. Page numbers are not available in our copy. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Exposure to high molecular weight phthalates is associated with allergies and asthma.

    “Exposure to high molecular weight phthalates are is associated with allergies and asthma [200,201].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [200]

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Authors
Braun, J. M., Sathyanarayana, S., & Hauser, R.
Affiliations
  • Brown University (US)
  • University of Washington (US)
  • Harvard University (US)
Corresponding author
Braun, Joseph M.
ORCID
Venue
Current Opinion in Pediatrics
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-04
Volume
25
Issue
2
Pages
247-254
ISSN
1040-8703 (ISSN-L)
DOI
10.1097/mop.0b013e32835e1eb6
PMC
PMC3747651
OpenAlex
W2000096982
Cited by
386
References
1
Citations by year
2026: 16 · 2025: 24 · 2024: 27 · 2023: 38 · 2022: 34 · 2021: 33 · 2020: 35 · 2019: 30 · 2018: 31 · 2017: 31 · 2016: 38 · 2015: 23 · 2014: 24 · 2013: 1
FWCI
3.40
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Environmental Health Sciences (R01ES009718, K99ES020346, R00ES020346, R01ES021357)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
phthalates, children's exposure, prenatal exposure, DEHP, butyl benzyl phthalate, dibutyl phthalate, diethyl phthalate, allergic diseases, asthma, atopic dermatitis, child behavior, autism-like behavior, anogenital distance, fetal development, personal care products, anticipatory guidance
MeSH terms
Asthma, Developmental Disabilities, Environmental Exposure, Environmental Pollutants, Female, Humans, Hypersensitivity, Phthalic Acids, Pregnancy, Prenatal Exposure Delayed Effects, Fetal Development

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