Cited by 212Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA MethylationBirth, Development, and Health

Phthalate exposure and long-term epigenomic consequences: a review

Open access
Dutta, Sudipta, Haggerty, Diana K., Rappolee, Daniel A., Ruden, Douglas M.·2020·Frontiers in Genetics

Abstract

Phthalates are esters of phthalic acid widely used as plasticizers to soften and increase the flexibility in polyvinyl chloride (PVC) plastics. They are also used in cosmetics and other daily personal care products. Phthalates are not covalently bound to plastics and easily leach into the environment and enter the human body by dermal absorption, ingestion or inhalation. Several in vitro and in vivo studies suggest that phthalates can act as endocrine disruptors and cause moderate reproductive and developmental toxicities. Furthermore, phthalates can cross the placental barrier and affect the developing fetus. Thus, phthalates are ubiquitous food and environmental contaminants with potential adverse health effects in humans. This review focusses on studies conducted in the field of toxicogenomics of phthalates and discusses possible transgenerational and multigenerational effects caused by phthalate exposure during any point of the life-cycle.

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Crossref · 10.3389/fgene.2020.00405

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Research works printed but not linked: 3

  1. ATSDR (2001). Toxicological Profile for di-n-butyl phthalate (DBP). Atlanta, GA. Available online at: http://www.atsdr.cdc.gov/toxprofiles 37931045
  2. ATSDR (2002). Toxicological Profile for di(2-ethylhexyl)phthalate (DEHP). Atlanta, GA. Available online at: http://www.atsdr.cdc.gov/toxprofiles 37040457
  3. National Toxicology Program (2019). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-ethylhexyl) Phthalate (DEHP). NIH Pub. No. 06– 4476. 19407857

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Authors
Dutta, S., Haggerty, D. K., Rappolee, D. A., & Ruden, D. M.
Affiliations
  • University of Nebraska Medical Center (US)
  • Michigan State University (US)
  • Wayne State University (US)
Corresponding author
Ruden, Douglas M.
Venue
Frontiers in Genetics
Published
2020-05-06
Volume
11
Pages
405-405
ISSN
1664-8021 (ISSN-L)
OpenAlex
W3023341510
Cited by
212
References
234
Citations by year
2026: 29 · 2025: 49 · 2024: 35 · 2023: 38 · 2022: 35 · 2021: 25 · 2020: 1
FWCI
2.14
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Foundation for the National Institutes of Health
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
phthalates, plasticizers, endocrine disruptors, epigenetics, toxicogenomics, transgenerational epigenetic inheritance, multigenerational effects, reproductive toxicity, developmental toxicity, placental transfer, dermal exposure, environmental pollutants, food contaminants

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