Psychiatric disorders as risk factors for adverse medical outcomes after solid organ transplantation
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PURPOSE OF REVIEW: Given that the prevalence of psychiatric disorders in transplant candidates and recipients is substantially higher than in the general population, and that linkages between psychiatric disorders and medical outcomes for nontransplant-related diseases have been established, it is important to determine whether psychiatric disorders predict posttransplant medical outcomes. RECENT FINDINGS: Most research has focused on the association between depression (both pretransplant and posttransplant) and posttransplant mortality. Some research has examined transplant-related morbidity outcomes, such as graft rejection, posttransplant malignancies, and infection. However, methodological limitations make it difficult to compare existing studies in this literature directly. Overall, the studies presented in this review indicate that psychiatric distress occurring in the early transplant aftermath bears a stronger relationship to morbidity and mortality outcomes than psychiatric distress occurring before transplant. SUMMARY: The literature on the impact of psychiatric conditions on the morbidity and mortality of solid organ transplant recipients remains inconclusive. More research is needed in order to investigate these associations among a broader range of psychiatric predictors, morbidity outcomes, and recipient populations. Until evidence suggests otherwise, we recommend frequent monitoring of psychiatric symptoms during the first year after transplantation to aid in early identification and treatment during this critical period of adjustment.
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Depressive symptoms prior to transplant have been linked to poorer transplant outcomes.
“Depressive symptoms prior to transplant have been linked to poorer transplant outcomes.(100–104)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [104]
The Mortality section reports that high depressive symptoms while on the waitlist were linked to higher posttransplant mortality in heart recipients with ischemic cardiomyopathy, but not those with dilated cardiomyopathy. It also reports no apparent survival effect of pretransplant depression in the liver studies and no mortality association in two kidney studies. The claim captures a reported link but generalizes beyond the conditions in which the review found it. (LLM, conf=0.86)
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Rogach, T., Woleská, J., Cavalli, C., & Annema, C. (2026) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000001274 · Cited by 1 · see citing works
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Psychosocial Evaluation for Lung Transplantation: an Empirically Informed Update
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THE INFLUENCE OF ILLNESS BURDEN AND SOCIAL SUPPORT ON THE COMPLETION OF KIDNEY TRANSPLANT EVALUATION
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Ask the Expert: Psychosomatic Medicine
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Special Considerations in Pediatric Transplant Patients
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- Authors
- Rosenberger, E. M., Dew, M. A., Crone, C., & DiMartini, A. F.
- Affiliations
- University of Pittsburgh (US)
- Virginia Commonwealth University (US)
- Corresponding author
- DiMartini, Andrea F.
- Venue
- Current Opinion in Organ Transplantation
- Published
- 2012-04
- Volume
- 17
- Issue
- 2
- Pages
- 188-192
- ISSN
- 1087-2418 (ISSN-L)
- PMC
- PMC4470498
- OpenAlex
- W2313484522
- Semantic Scholar
- a1a2e6b12ebc65a541ea1fc8745ea779cd71c01f
- Cited by
- 83
- References
- 23
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 3
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Organ Transplantation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (TL1TR000145)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Keywords
- mental illness, solid organ transplantation, depression, post-transplant mortality, graft rejection, post-transplant malignancy, post-transplant infection, transplant recipients, psychiatric distress, risk factors, psychiatric monitoring
- MeSH terms
- Anxiety Disorders, Depressive Disorder, Humans, Morbidity, Psychotic Disorders, Risk Factors, Comorbidity, Organ Transplantation, Treatment Outcome
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