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Cited by 115Organ Transplantation Techniques and OutcomesOrgan and Tissue Transplantation ResearchLiver Disease and Transplantation

Early trajectories of depressive symptoms after liver transplantation for alcoholic liver disease predicts long-term survival

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DiMartini, A., Dew, M.A., Chaiffetz, D., Fitzgerald, M.G., deVera, M.E., Fontes, P.·2011·American Journal of Transplantation
DOI 10.1111/j.1600-6143.2011.03496.xPMC PMC4133126
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Abstract

Although it is well known that depression is associated with poorer medical outcomes, the association between depression- and liver transplant (LTX)-specific outcomes has not been investigated. We identified three trajectories of depressive symptoms evolving within the first post-LTX year in a cohort of 167 patients transplanted for alcoholic cirrhosis: a group with consistently low depression levels at all time points (group 1, n = 95), a group with initially low depression levels that rose over time (group 2, n = 41), and a group with consistently high depression levels (group 3, n = 31). Controlling for medical factors associated with poorer survival, recipients with increasing depression or persisting depression were more than twice as likely to die (all cause mortality) within the subsequent years. At 10 years post-LTX the survival rate was 66% for the low depression group, but only 46% and 43%, respectively, for the increasing depression and high depression groups. Except for a paradoxically higher percentage of malignancies in the low depression group, the causes of death and other specific LTX outcomes were not different between groups. Whether treatment of depression will improve survival rates is an area for research.

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Crossref · 10.1111/j.1600-6143.2011.03496.x

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  • DiMartini and colleagues reported the lifetime prevalence of clinical anxiety per DSM-IV criterion to be 13% among 167 patients with alcohol-associated liver disease before liver transplant.

    “As part of a prospective longitudinal study, DiMartini and colleagues reported the lifetime prevalence of clinical DEP and ANX, per DSM-IV criterion, to be 20% and 13%, respectively, among 167 patients with ALD before liver transplant.”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [7]

  • DiMartini and colleagues reported the lifetime prevalence of clinical depression per DSM-IV criterion to be 20% among 167 patients with alcohol-associated liver disease before liver transplant.

    “As part of a prospective longitudinal study, DiMartini and colleagues reported the lifetime prevalence of clinical DEP and ANX, per DSM-IV criterion, to be 20% and 13%, respectively, among 167 patients with ALD before liver transplant.”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [7]

  • The lifetime prevalence of clinical depression was the strongest predictor of survival, conferring a 2-time higher risk of mortality among patients with alcohol-associated liver disease.

    “The authors also showed that the lifetime prevalence of clinical DEP was the strongest predictor of survival, conferring a 2-time higher risk of mortality among patients with ALD.[7]”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [7]

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Research works printed but not linked: 2

  1. [4]First Michael Diagnostic and statistical manual for mental disorders 4 Washington, DC American Psychiatric Press 1994
  2. [15]Everitt BS Landau S Leese M Cluster analysis 4 New York Oxford University Press 2001

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Authors
DiMartini, A., Dew, M. A., Chaiffetz, D., Fitzgerald, M. G., deVera, M. E., & Fontes, P.
Affiliations
  • University of Pittsburgh (US)
  • University of Pittsburgh Medical Center (US)
Corresponding author
DiMartini, A.
ORCID
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2011-06
Volume
11
Issue
6
Pages
1287-1295
ISSN
1600-6135 (ISSN-L)
DOI
10.1111/j.1600-6143.2011.03496.x
PMC
PMC4133126
OpenAlex
W1479841946
Cited by
115
References
26
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 16 · 2014: 6 · 2013: 5 · 2012: 10
FWCI
6.88
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (K23AA000257, K23-AA0257)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK066266)
  • National Center for Research Resources (UL1RR024153)
Topics
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
depressive symptoms, liver transplantation, alcoholic liver disease, alcoholic cirrhosis, depression trajectories, long-term survival, mortality, post-transplant depression
MeSH terms
Adult, Female, Humans, Liver Diseases, Alcoholic, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Cohort Studies, Survival Analysis, Liver Transplantation

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