Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
Open accessAbstract
Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, “Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study,” that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.
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Cites
Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus
Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.039 · Cited by 621 · see citing works
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Is screening for pancreatic cancer in high-risk individuals one step closer or a fool's errand?
Hart, P. A., & Chari, S. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.024 · Cited by 32 · see citing works
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Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482 · see citing works
Self-citationArtificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
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Is screening for pancreatic cancer in high-risk individuals one step closer or a fool's errand?
Hart, P. A., & Chari, S. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.024 · Cited by 32 · see citing works
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- Authors
- Hart, P. A., Andersen, D. K., Mather, K. J., Castonguay, A. C., Bajaj, M., Bellin, M. D., Bradley, D., Contreras, N., Habtezion, A., Korc, M., Kudva, Y., Petrov, M. S., Whitcomb, D. C., Yadav, D., Yuan, Y., Rinaudo, J. A. S., Srivastava, S., Serrano, J., & Goodarzi, M. O.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- National Institutes of Health (US)
- Indiana University School of Medicine (US)
- Mayo Clinic (US)
- Baylor College of Medicine (US)
- University of Minnesota (US)
- The University of Texas MD Anderson Cancer Center (US)
- Stanford Medicine (US)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center (US)
- University of Auckland (NZ)
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD;
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Hart, Phil A.
- Bradley, David
- Rinaudo, Jo Ann S.
- Srivastava, Sudhir
- ORCID
- Venue
- Pancreas
- Published
- 2018-11
- Volume
- 47
- Issue
- 10
- Pages
- 1239-1243
- ISSN
- 0885-3177 (ISSN-L)
- 1536-4828
- PMC
- PMC6195331
- OpenAlex
- W2896807874
- Cited by
- 46
- References
- 3
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 5
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327, U01DK108326, L30 DK118657, U01DK108300, U01DK108306, U01DK108323, U01DK108314, U01DK108328, P30DK097512, U01DK108288)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- pancreatic diabetes, mixed meal tolerance test, pancreatic cancer, chronic pancreatitis, type 2 diabetes, glycemic excursions, pancreatic hormones, diagnostic biomarkers, biorepository
- MeSH terms
- Clinical Studies as Topic, Adult, Aged, Diabetes Mellitus, Diagnostic Tests, Routine, Humans, Middle Aged, Pancreatic Neoplasms, Pancreatitis, Research Design, Sensitivity and Specificity, Reproducibility of Results, Multicenter Studies as Topic, Biomedical Research, Pancreatitis, Chronic
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