Management of chronic pancreatitis
Open accessAbstract
Chronic pancreatitis results from repeated episodes of pancreatic inflammation and associated fibrosis leading to the loss of functional exocrine and endocrine pancreatic function. The disease is manifested by abdominal pain, deterioration in quality of life, food maldigestion and malabsorption, diabetes, and an increased risk for pancreatic adenocarcinoma. This review summarizes the latest evidence on the diagnosis and management of chronic pancreatitis and its manifestations. In particular, this review discusses advances in understanding of the role of genetic disorders in the mechanisms of the disease and surgical options for patients refractory to medical therapy. Furthermore, clinical trials are under way to develop medical therapeutics.
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Acute (even a single bout) and chronic pancreatitis can lead to postpancreatitis diabetes mellitus.
“Acute (even a single bout) and chronic pancreatitis can lead to postpancreatitis diabetes mellitus (117).”
From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [117]
The Introduction states that chronic pancreatitis can result in diabetes, and the section on exocrine and endocrine insufficiency calls this post-pancreatitis diabetes. Our copy does not say that acute pancreatitis, including a single bout, can lead to it. (LLM, conf=0.88)
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Metabolism and Targeted Therapy of Fibrosis in Chronic Pancreatitis: A Review
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ENPP1-Regulated Extracellular Purine Metabolism Drives Pancreatitis-Mediated Pancreatic Cancer
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Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)
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Advancing Gene Therapy for Pancreatitis: From Genetic Insights to Clinical Translation
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Alteration of Apolipoprotein A2 Isoforms is Associated With the Progression of Chronic Pancreatitis
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A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression
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Liver–pancreas communication in disease and drug development
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Updates in the Management of Chronic Pancreatitis
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Updates in endoscopic management of pain in chronic pancreatitis
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ORM2 alleviates pancreatic fibrosis in chronic pancreatitis by modulating autophagy via ZG16
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Harnessing extracellular vesicles for pancreatic fibrosis therapy
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Progress in treatment of chronic pancreatitis: A review based on the ClinicalTrials.gov database
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Impact of Lipid-Lowering Therapy on Pancreatic Health: Insights from Mendelian RandomizationPreprint
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Advances in research of metabolic bone disease secondary to chronic pancreatitis
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Spinal HDAC2 Influences the Development of Chronic Pancreatitis-Related Pain through mGluR2
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Research Progress on Chronic Pancreatitis
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Self-citationHealthy Aging: Concept, Global Actions, and the Role of ICT
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Endoscopic Management of Chronic Pancreatitis in Children: A Single-center Experience Over a Decade
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Association between increased suicide death rates and pancreatitis: A nationwide cohort study
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The impact of disease states on secretory function in the gastrointestinal tract
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Self-citationEpidemiological trends in pancreatitis in China and the United States, 1990–2023
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- Authors
- Hines, O. J., & Pandol, S. J.
- Affiliations
- University of California, Los Angeles (US)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Pandol, Stephen J
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2024-02-26
- Volume
- 384
- Pages
- e070920
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W4392155304
- Cited by
- 58
- References
- 159
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 14
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
- Keywords
- chronic pancreatitis, pancreatic fibrosis, exocrine pancreatic insufficiency, pancreatic endocrine dysfunction, abdominal pain, diabetes mellitus, pancreatic ductal adenocarcinoma, genetic disorders, surgical management, refractory disease, medical therapy
- MeSH terms
- Adenocarcinoma, Humans, Pancreatic Neoplasms, Quality of Life, Pancreatitis, Chronic
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