Cited by 58Pancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchIgG4-Related and Inflammatory Diseases

Management of chronic pancreatitis

Open access
Hines, O Joe, Pandol, Stephen J·2024·BMJ

Abstract

Chronic pancreatitis results from repeated episodes of pancreatic inflammation and associated fibrosis leading to the loss of functional exocrine and endocrine pancreatic function. The disease is manifested by abdominal pain, deterioration in quality of life, food maldigestion and malabsorption, diabetes, and an increased risk for pancreatic adenocarcinoma. This review summarizes the latest evidence on the diagnosis and management of chronic pancreatitis and its manifestations. In particular, this review discusses advances in understanding of the role of genetic disorders in the mechanisms of the disease and surgical options for patients refractory to medical therapy. Furthermore, clinical trials are under way to develop medical therapeutics.

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Crossref · 10.1136/bmj-2023-070920

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158 of 158 references verified0 citation errors · 0 not checkable

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  • Acute (even a single bout) and chronic pancreatitis can lead to postpancreatitis diabetes mellitus.

    “Acute (even a single bout) and chronic pancreatitis can lead to postpancreatitis diabetes mellitus (117).”

    From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [117]

    The Introduction states that chronic pancreatitis can result in diabetes, and the section on exocrine and endocrine insufficiency calls this post-pancreatitis diabetes. Our copy does not say that acute pancreatitis, including a single bout, can lead to it. (LLM, conf=0.88)

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1 of the 159 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Comfort MW, Gambill EE, Baggenstoss AH. Chronic relapsing pancreatitis; a study of 29 cases without associated disease of the biliary or gastrointestinal tract. Gastroenterology 1946;6:376-408.
  2. Capurso G, Archibugi L, Pasquali P, et al. Prevalence of chronic pancreatitis: Results of a primary care physician-based population study. Dig Liver Dis 2017;49:535-9. doi:10.1016/j.dld.2016.12.024 · DOI
  3. Hart PA, Andersen DK, Mather KJ, et al, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 2018;47:1239-43. doi:10.1097/MPA.0000000000001168 111 · DOI
  4. Larvin M, McMahon MJ, Thomas WEG, Puntis MCA. Creon (enteric coated Pancreatin microspheres) for the treatment of pain in chronic pancreatitis: a doubleblind randomised placebo-controlled crossover study. Gastroenterology 1991;100:A283. 122
  5. Mössner J, Secknus R, Meyer J, Niederau C, Adler G. Treatment of pain with pancreatic extracts in chronic pancreatitis: results of a prospective placebo-controlled multicenter trial. Digestion 1992;53:54-66. doi:10.1159/000200971 123 · DOI

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Authors
Hines, O. J., & Pandol, S. J.
Affiliations
  • University of California, Los Angeles (US)
  • Cedars-Sinai Medical Center (US)
Corresponding author
Pandol, Stephen J
Venue
BMJ
Publisher
BMJ
Published
2024-02-26
Volume
384
Pages
e070920
ISSN
1756-1833 (ISSN-L)
OpenAlex
W4392155304
Cited by
58
References
159
Citations by year
2026: 22 · 2025: 22 · 2024: 14
FWCI
6.43
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
Keywords
chronic pancreatitis, pancreatic fibrosis, exocrine pancreatic insufficiency, pancreatic endocrine dysfunction, abdominal pain, diabetes mellitus, pancreatic ductal adenocarcinoma, genetic disorders, surgical management, refractory disease, medical therapy
MeSH terms
Adenocarcinoma, Humans, Pancreatic Neoplasms, Quality of Life, Pancreatitis, Chronic

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