Is screening for pancreatic cancer in high-risk individuals one step closer or a fool's errand?
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Finding PDAC before cachexia worsens performance status raises the chance that eligible patients can undergo resection.
“Second, early detection before the decline in performance status from cancer-induced cachexia increases the prospect of surgical resection in eligible patients.2,5”
From Radiomics-based Machine-learning Models Can Detect Pancreatic Cancer on Prediagnostic Computed Tomography Scans at a Substantial Lead Time Before Clinical Diagnosis (2022) · cites this paper as [5]
The paper’s opening section (page unavailable) says that most PDAC is diagnosed at an advanced stage, only 10–15% of patients are candidates for potentially curative treatment including surgery, and early diagnosis requires detection before symptoms. It does not mention cachexia or declining performance status as the reason earlier detection could improve the prospect of resection. (LLM, conf=0.84)
Experimental — accuracy not yet measuredScreening asymptomatic adults at average risk for pancreatic ductal adenocarcinoma is not feasible or recommended with current modalities.
“Pancreatic ductal adenocarcinoma is relatively uncommon and screening of the asymptomatic adult population is not feasible or recommended with current modalities.”
From Early detection of pancreatic cancer (2020) · cites this paper as [16]
Existing diagnostic methods for pancreatic ductal adenocarcinoma would produce unacceptably high false-positive rates if used for population screening.
“Existing diagnostic methods would incur unacceptably high rates of false-positive findings,16”
From Early detection of pancreatic cancer (2020) · cites this paper as [16]
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Cites
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Research works printed but not linked: 1
- [16]Hart P, Stanich P, Hampel H. Screening for pancreatic cancer: who to screen and how to follow-up? Current and Emerging Therapies in Pancreatic Cancer: Springer Nature, 2017: 97– 108.
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- Authors
- Hart, P. A., & Chari, S. T.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Mayo Clinic (US)
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 17
- Issue
- 1
- Pages
- 36-38
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC6557281
- OpenAlex
- W2892558594
- Cited by
- 32
- References
- 15
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 2
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases (DK108327, DK108288)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- pancreatic cancer screening, pancreatic ductal adenocarcinoma, high-risk individuals, early detection, advanced-stage diagnosis, survival outcomes, curative treatment
- MeSH terms
- Humans, Mass Screening, Pancreatic Neoplasms, Cohort Studies, Early Detection of Cancer
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