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Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers
Open accessAbstract
OBJECTIVES: In pancreatic cancer (PaC), the prevalence of diabetes mellitus (DM), especially new-onset DM (≤36 months of PaC diagnosis), is high. To determine if this observation is unique to PaC, we compared the prevalence and characteristics of DM in lung, breast, prostate, and colorectal cancers with PaC and noncancer controls. METHODS: We retrospectively reviewed the medical records of 500 consecutive patients with cancer (100 each with lung, breast, prostate, and colorectal cancers and PaC) and 100 noncancer controls. RESULTS: Patients with PaC (mean age ± SD, 71.6 ± 9.4 years; 53% men) had a significantly (P < 0.0001) higher prevalence of DM (68%) compared to age-matched patients with lung (mean age ± SD, 71.6 ± 9.4 years; 59% men; and 19.6% DM), breast (mean age ± SD, 71.6 ± 9.6 years; 100% women; and 19.4% DM), prostate (mean age ± SD, 71.3 ± 9.4 years; 100% men; and 14.8% DM), and colorectal cancer (mean age ± SD, 71.6 ± 9.5 years; 56% men; and 20.7% DM), and noncancer controls (mean age ± SD, 70.7 ± 9.2 years; 57% men; and 23.5% DM). Among the patients with PaC, 40% developed DM in the 36 months preceding the diagnosis of PaC compared with 3.3% to 5.7% in the other groups (P < 0.0001). CONCLUSIONS: Whereas the prevalence of DM in PaC is very high, DM prevalence in other common cancers is no different from that in noncancer controls. In particular, new-onset DM is a phenomenon that is unique to PaC.
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“The prevalence of diabetes among patients diagnosed with PDAC is remarkably higher than for any other solid tumor,211”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [211]
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Metadata
- Authors
- Aggarwal, G., Kamada, P., & Chari, S. T.
- Affiliations
- Mayo Clinic (US)
- University Medical Center Brackenridge (US)
- Corresponding author
- Aggarwal, Gaurav
- Chari, Suresh T.
- Venue
- Pancreas
- Published
- 2013-03
- Volume
- 42
- Issue
- 2
- Pages
- 198-201
- ISSN
- 0885-3177 (ISSN-L)
- PMC
- PMC3896296
- OpenAlex
- W2045036543
- Cited by
- 167
- References
- 21
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 23 · 2020: 19 · 2019: 17 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 9
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50CA102701, R01CA100685)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- diabetes mellitus, pancreatic cancer, new-onset diabetes, cancer-associated diabetes, lung cancer, breast cancer, prostate cancer, colorectal cancer, diabetes prevalence, cancer patients
- MeSH terms
- Aged, Aged, 80 and over, Blood Glucose, Breast Neoplasms, Diabetes Mellitus, Female, Humans, Lung Neoplasms, Male, Middle Aged, Minnesota, Pancreatic Neoplasms, Prostatic Neoplasms, Retrospective Studies, Risk Factors, Time Factors, Colorectal Neoplasms, Biomarkers, Prevalence, Chi-Square Distribution
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