Academic stress may contribute to the onset of pediatric inflammatory bowel diseases
Abstract
It is currently unclear whether seasonality affects the onset of inflammatory bowel diseases (IBDs: Crohn disease and ulcerative colitis) in children. Here, we examined the records of pediatric patients with IBD diagnosed between 2009 and 2015 in a discovery cohort of 169 cases and a validation cohort of 122 subjects, where the month of symptoms onset could be determined. No seasonal patterns could be identified in respect to conception, birth, and disease onset. An annual rhythm of symptomatic onset, however, correlating with academic semesters was identified. IBD symptoms in the discovery cohort presented significantly more (P = 0.0218) during 5 months including the initiation (August, September, January) and the termination of academic semesters (December, May) compared to any other 5 months of the year. This observation was validated in the independent cohort (P < 0.0001). Our findings imply that academic stress may contribute to disease onset in pediatric IBD, which may improve timely diagnosis.
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Academic stress may facilitate disease onset in pediatric IBD.
“The results showed that academic stress may facilitate disease onset in pediatric IBD (82).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [82]
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Frankiensztajn, L. M., Elliott, E., & Koren, O. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.12.003 · Cited by 248 · see citing works
Stress triggers flare of inflammatory bowel disease in children and adults
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- Authors
- Krishna, M. Z., Barton, K. R., Perez, C. M., Walsh, S. M., Assa, A., & Kellermayer, R.
- Affiliations
- Baylor College of Medicine (US)
- Tel Aviv University (IL)
- Section of Pediatric Gastroenterology Baylor College of Medicine Houston TX
- Corresponding author
- Krishna, Mahesh Z.
- Barton, Keisha R.
- Perez, Carla M.
- Walsh, Seema M.
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2018-10
- Volume
- 67
- Issue
- 4
- Pages
- e73-e76
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2807251444
- Cited by
- 13
- References
- 22
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 3
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- pediatric inflammatory bowel disease, Crohn's disease, ulcerative colitis, academic stress, academic semester, seasonal variation, disease onset, timely diagnosis
- MeSH terms
- Academic Performance, Adolescent, Child, Female, Humans, Male, Seasons, Stress, Psychological, Inflammatory Bowel Diseases, Cohort Studies
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