Response to Hepatitis A and B Vaccination in Pediatric Patients With Celiac Disease
Abstract
Objectives: The aim of the study was to evaluate the response to hepatitis A and B vaccinations in pediatric patients with celiac disease (CD). Methods: Thirty patients with CD ages 1 to 15 years were compared with 50 healthy age‐, sex‐, and body mass index–matched controls. Screening for hepatitis A and B serology was carried out before vaccination. Susceptible cases received 20 μg of recombinant DNA vaccine for hepatitis B (0,1, and 6 months) and 720 milliELISA units of inactivated hepatitis A virus (HAV) vaccine (0 and 6 months). Postvaccination serologic evaluation was performed 1 month after the last dose of primary vaccination, 1 month after the booster dose, and once every year during follow‐up. Results: Sixteen patients and 35 controls received hepatitis A vaccine; protective anti‐HAV antibodies were developed in 12 (75%) of the patients and all of the controls (75% vs 100%, respectively; 95% confidence interval [CI] 0.47–0.92, P = 0.007). Thirty patients and 50 controls received hepatitis B vaccine, and 70% of the patients vs 90% of the controls achieved seroprotection (anti‐HBs titers ≥10 mIU/mL) 1 month after primary vaccination (95% CI 0.74–0.90, P = 0.03). Four patients were unresponsive to both of the vaccines. The overall seroprotection rates were 96% in controls and 80% in patients after the whole hepatitis B vaccination series (95% CI 0.04–0.18, P = 0.04). No significant reduction was observed in antibody response among patients and controls during follow‐up period. Conclusions: The rate of seroconversion to the hepatitis B virus‐ and HAV vaccine is lower in patients with CD than in healthy controls.
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HBV vaccine has been shown to potentially have a reduced response, with 50% of patients with coeliac disease having a poor antibody response vs. 11% of controls in case of vaccination within the first 6 months of life.
“Concerning immunization, HBV vaccine has been shown to potentially have a reduced response, with 50% of patients with CD having a poor antibody response vs. 11% of controls in case of vaccination within the first 6 months of life (41-43).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [42]
A second dose effectively induces protective levels in those coeliac disease children.
“A second dose effectively induces protective levels in those CD children (41-44).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [42]
One study reported reduced protection after HAV vaccination.
“In addition, one study reported reduced protection after HAV vaccination (42).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [42]
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- Authors
- Urganci, N., & Kalyoncu, D.
- Affiliations
- Division of Pediatric Gastroenterology Sisli Etfal Training and Research Hospital Istanbul Turkey
- Şişli Etfal Eğitim ve Araştırma Hastanesi (TR)
- ORCID
- Kalyoncu, Derya
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2013-04
- Volume
- 56
- Issue
- 4
- Pages
- 408-411
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2314689659
- Cited by
- 25
- References
- 32
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2012: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Keywords
- celiac disease, hepatitis A vaccine, hepatitis B vaccine, vaccine response, seroprotection, anti-HAV antibodies, anti-HBs antibodies, pediatric patients, vaccine immunogenicity
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Female, Follow-Up Studies, Hepatitis B Antibodies, Hepatitis B virus, Humans, Infant, Male, Prospective Studies, Vaccines, Inactivated, Hepatitis B Vaccines, Hepatitis A Virus, Human, Vaccines, DNA, Hepatitis A Vaccines, Hepatitis A Antibodies, Immunity, Humoral
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