Cited by 195Metabolomics and Mass Spectrometry StudiesDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

Jové, Mariona, Portero-Otín, Manuel, Naudí, Alba, Ferrer, Isidre, Pamplona, Reinald·2014·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/nen.0000000000000091

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Abstract

Neurons in the mature human central nervous system (CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output requires a great diversity of CNS neuronal and non-neuronal populations. Metabolomics encompasses the study of the complete set of metabolites/low-molecular-weight intermediates (metabolome), which are context-dependent and vary according to the physiology, developmental state, or pathologic state of the cell, tissue, organ, or organism. Therefore, the use of metabolomics can help to unravel the diversity-and to disclose the specificity-of metabolic traits and their alterations in the brain and in fluids such as cerebrospinal fluid and plasma, thus helping to uncover potential biomarkers of aging and neurodegenerative diseases. Here, we review the current applications of metabolomics in studies of CNS aging and certain age-related neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. Neurometabolomics will increase knowledge of the physiologic and pathologic functions of neural cells and will place the concept of selective neuronal vulnerability in a metabolic context.

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Authors: Jové, M., Portero-Otín, M., Naudí, A., Ferrer, I., & Pamplona, R.
Affiliations: Universitat de Lleida (ES)
Corresponding author: Pamplona, Reinald
ORCID: Jové, Mariona
Naudí, Alba
Pamplona, Reinald
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2014-07
Volume: 73
Issue: 7
Pages: 640-657
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/nen.0000000000000091
OpenAlex: W2317167530
Cited by: 195
References: 215
Citations by year: 2026: 5 · 2025: 8 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 21 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 22 · 2016: 19 · 2015: 20 · 2014: 3
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: brain aging, age-related neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebrospinal fluid metabolites, plasma metabolites, aging biomarkers, selective neuronal vulnerability, central nervous system metabolism
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Energy Metabolism, Female, Humans, Male, Neurons, Parkinson Disease, Species Specificity, Biomarkers, Neurodegenerative Diseases, Metabolomics

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Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

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