CoChat
Sign Up
Cited by 28HIV/AIDS Research and InterventionsSexual Assault and Victimization StudiesHIV, Drug Use, Sexual Risk

Post-exposure prophylaxis for HIV infection in sexual assault victims.

Open access
Inciarte, A, Leal, L, Masfarre, L, Gonzalez, E, Diaz‐Brito, V, Lucero, C, Garcia‐Pindado, J, León, A +2 more·2020·HIV Medicine
DOI 10.1111/hiv.12797PMC PMC6916272
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVES: Sexual assault (SA) is recognized as a public health problem of epidemic proportions. Guidelines recommend the administration of post-exposure prophylaxis (PEP) after an SA. However, few data are available about the feasibility of this strategy, and this study was conducted to assess this. METHODS: We conducted a retrospective, longitudinal, observational study in SA victims attending the Hospital Clinic in Barcelona from 2006 to 2015. A total of 1695 SA victims attended the emergency room (ER), of whom 883 met the PEP criteria. Five follow-up visits were scheduled at days 1, 10, 28, 90 and 180 in the out-patient clinic. The primary endpoint was PEP completion rate at day 28. Secondary endpoints were loss to follow-up, treatment discontinuation, occurrence of adverse events (AEs) and rate of seroconversion. RESULTS: The median age of participants was 25 years [interquartile range (IQR) 21-33 years] and 93% were female. The median interval between exposure and presentation at the ER was 13 h (IQR 6-24 h). The level of risk was appreciable in 47% (n = 466) of individuals. Of 883 patients receiving PEP, 631 lived in Catalonia. In this group, the PEP completion rate at day 28 was 29% (n = 183). The follow-up rate was 63% (n = 400) and 38% (n = 241) at days 1 and 28, respectively. Treatment discontinuation was present in 58 (15%) of 400 patients who attended at least the day 1 visit, the main reason being AEs (n = 35; 60%). AEs were reported in 226 (56%) patients, and were mainly gastrointestinal (n = 196; 49%). Only 211 (33%) patients returned for HIV testing at day 90. A single seroconversion was observed in a men who have sex with men (MSM) patient at day 120. CONCLUSIONS: Follow-up and compliance rates in SA victims were poor. In addition, > 50% of the patients experienced AEs, which were the main reason for PEP interruption. Strategies to increase follow-up testing and new better tolerated drug regimens must be investigated to address these issues.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/hiv.12797

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Severe adverse effects are rare from PEP.

    “Providers should emphasize that severe adverse effects are rare from PEP (1431–1435).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1435]

    The Results section on abnormal laboratory values reports no discontinuations related to clinically relevant laboratory abnormalities. But the paper does not report a rate for severe adverse effects overall; its adverse-events Results report that 226 of 400 patients reported an adverse event. The narrower laboratory finding does not establish that severe adverse effects from PEP are rare in general. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [10]Xifró‐Collsamata A, Pujol‐Robinat A, Medallo‐Muñiz J et al A prospective study of drug‐facilitated sexual assault in Barcelona. Med Clin (Barc) 2015; 144: 403– 409. 25748993
  2. [23]Powers KA, Poole C, Cohen MS et al Systematic review and meta‐analysis of the per‐heterosexual‐contact probability of HIV‐1 transmission. Lancet Infect Dis 2008; 8: 553– 563. 18684670 PMC2744983

Cited by

Sorted by citations

Related

Authors
Inciarte, A., Leal, L., Masfarre, L., Gonzalez, E., Diaz‐Brito, V, Lucero, C., Garcia‐Pindado, J., León, A., García, F., & the Sexual Assault Victims Study Group
Affiliations
  • Hospital Clínic de Barcelona (ES)
  • Universitat de Barcelona (ES)
  • Infectious Diseases Unit Hospital Clinic of Barcelona Barcelona Spain
Corresponding author
Inciarte, A
ORCID
Venue
HIV Medicine
Publisher
Wiley
Published
2019-10-11
Volume
21
Issue
1
Pages
43-52
ISSN
  • 1464-2662 (ISSN-L)
  • 1468-1293
DOI
10.1111/hiv.12797
PMC
PMC6916272
OpenAlex
W2979450068
Cited by
28
References
44
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 2 · 2021: 3
FWCI
0.96
Type
journal article
Language
en
Open access
Licence
Locations
  • HIV Medicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Instituto de Salud Carlos III (RD16/0025)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Social Sciences › Gender Studies › Sexual Assault and Victimization Studies
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords
HIV post-exposure prophylaxis, sexual assault, HIV infection, follow-up adherence, adverse events, seroconversion, HIV testing, men who have sex with men, emergency department care, treatment discontinuation, sexual assault survivors, Catalonia, HIV prevention guidelines, sexual risk assessment
MeSH terms
Assessment of Medication Adherence, Adult, Female, Humans, Longitudinal Studies, Male, Retrospective Studies, Sex Offenses, Spain, HIV Infections, Drug Monitoring, Practice Guidelines as Topic, Anti-HIV Agents, Medication Adherence, Young Adult, Post-Exposure Prophylaxis, Lost to Follow-Up

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review