The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Basic Mechanisms of Therapeutic Resistance to Radiation and Chemotherapy in Lung Cancer
Open accessAbstract
In recent years, there have been multiple breakthroughs in our understanding of lung cancer biology. Despite significant advances in molecular targeted therapies, DNA-damaging cytotoxic therapies will remain the mainstay of lung cancer management for the near future. Similar to the concept of personalized targeted therapies, there is mounting evidence that perturbations in DNA repair pathways are common in lung cancers, altering the resistance of the affected tumors to many chemotherapeutics as well as radiation. Defects in DNA repair may be due to a multitude of mechanisms including gene mutations, epigenetic events, and alterations in signal transduction pathways such as epidermal growth factor receptor and phosphoinositide 3-kinase/AKT. Functional biomarkers that assess the subcellular localization of central repair proteins in response to DNA damage may prove useful for individualization of cytotoxic therapies including poly(adenosine diphosphate-ribose) polymerase inhibitors. A better mechanistic understanding of cellular sensitivity and resistance to DNA damaging agents should facilitate the development of novel, individualized treatment approaches. Absolute resistance to radiation therapy, however, does not exist. To some extent, radiation therapy will always have to remain unselective and indiscriminant to eradicate persistent, drug-resistant tumor stem cell pools.
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Cites
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“From there, mechanisms of resistance fall into broad categories best defined as pretarget, on-target, posttarget, and off-target resistance.(47) Pretarget, posttarget, and off-target mechanisms of resistance may overlap for a variety of drugs.”
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Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
Ye, L. F., Chaudhary, K. R., Zandkarimi, F., Harken, A. D., Kinslow, C. J., Upadhyayula, P. S., Dovas, A., Higgins, D. M., Tan, H., Zhang, Y., et al. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.9b00939 · Cited by 521
Contemporary radiotherapy: present and future
Chandra, R. A., Keane, F. K., Voncken, F. E. M., & Thomas, C. R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00233-6 · Cited by 380
Kim, K.-T., Lee, H. W., Lee, H.-O., Kim, S. C., Seo, Y. J., Chung, W., Eum, H. H., Nam, D.-H., Kim, J., Joo, K. M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0692-3 · Cited by 268
Yuan, D., Xu, J., Wang, J., Pan, Y., Fu, J., Bai, Y., Zhang, J., & Shao, C. (2016) · Oncotarget · doi:10.18632/oncotarget.9017 · Cited by 86
Long, L., Zhang, X., Bai, J., Li, Y., Wang, X., & Zhou, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s198966 · Cited by 21
Metadata
- Authors
- Willers, H., Azzoli, C. G., Santivasi, W. L., & Xia, F.
- Venue
- The Cancer Journal
- Published
- 2013-05
- Volume
- 19
- Issue
- 3
- Pages
- 200-207
- ISSN
- 1528-9117 (ISSN-L)
- OpenAlex
- W1977658535
- Cited by
- 208
- References
- 13
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Willers, H., Azzoli, C. G., Santivasi, W. L., & Xia, F. (2013). Basic Mechanisms of Therapeutic Resistance to Radiation and Chemotherapy in Lung Cancer. The Cancer Journal. https://doi.org/10.1097/ppo.0b013e318292e4e3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
