Cited by 159Asthma and respiratory diseasesStress Responses and CortisolOccupational exposure and asthma

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Double-Exposure to Acute Stress and Chronic Family Stress is Associated With Immune Changes in Children With Asthma

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Marin, Teresa J., Chen, Edith, Munch, Jennifer A., Miller, Gregory E.·2009·Psychosomatic Medicine

DOI 10.1097/psy.0b013e318199dbc3PMC PMC2735247

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Abstract

OBJECTIVE: To understand how psychological stress heightens risk for asthma flare-ups, we examined the relationship between acute stress, chronic family stress, and the production of asthma-related cytokines. METHODS: Seventy-one children with asthma and 76 medically healthy children completed interviews regarding life stress, and peripheral blood samples were collected. After mononuclear cells had been mitogenically stimulated, production of the cytokines interleukin (IL)-4, IL-5, IL-13, and IFN-gamma was measured. All measurements were repeated every 6 months for 2 years. Children reported on their asthma symptoms for 14 days after each study visit. RESULTS: Children with asthma who had higher levels of chronic family stress showed increased production of IL-4, IL-5, and IFN-gamma at times when they had experienced an acute event compared with times when they had not. These stress-related changes did not occur in asthmatic children with lower levels of chronic family stress, or in healthy controls. The combination of acute and chronic stress was also associated with increased asthma symptoms. CONCLUSION: These findings suggest that acute negative life events have a particularly strong impact among a subgroup of children with asthma who are under high chronic family stress. The heightened inflammatory profile in this group suggests an explanation for why children experiencing life stressors are at greater risk for asthma exacerbations.

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Authors: Marin, T. J., Chen, E., Munch, J. A., & Miller, G. E.
Affiliations: University of British Columbia (CA)
Corresponding author: Marin, Teresa J.
ORCID: Marin, Teresa J.
Chen, Edith
Miller, Gregory E.
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-05
Volume: 71
Issue: 4
Pages: 378-384
ISSN: 0033-3174 (ISSN-L)
DOI: 10.1097/psy.0b013e318199dbc3
PMC: PMC2735247
OpenAlex: W2124090260
Cited by: 159
References: 31
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 18
FWCI: 7.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL073975, R01HL073975)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: childhood asthma, psychological stress, acute stress, cytokines, IL-4, IL-5, IL-13, interferon-gamma, asthma exacerbations, immune response, mononuclear cell activation, asthma symptoms
MeSH terms: Acute Disease, Adolescent, Asthma, Child, Chronic Disease, Family Relations, Female, Follow-Up Studies, Humans, Interferon-gamma, Life Change Events, Male, Risk, Severity of Illness Index, Stress, Psychological, Interleukin-4, Interleukin-5, Th1 Cells, Th2 Cells, Interleukin-13, Anti-Asthmatic Agents

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Double-Exposure to Acute Stress and Chronic Family Stress is Associated With Immune Changes in Children With Asthma

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