The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Double-Exposure to Acute Stress and Chronic Family Stress is Associated With Immune Changes in Children With Asthma
Open accessAbstract
OBJECTIVE: To understand how psychological stress heightens risk for asthma flare-ups, we examined the relationship between acute stress, chronic family stress, and the production of asthma-related cytokines. METHODS: Seventy-one children with asthma and 76 medically healthy children completed interviews regarding life stress, and peripheral blood samples were collected. After mononuclear cells had been mitogenically stimulated, production of the cytokines interleukin (IL)-4, IL-5, IL-13, and IFN-gamma was measured. All measurements were repeated every 6 months for 2 years. Children reported on their asthma symptoms for 14 days after each study visit. RESULTS: Children with asthma who had higher levels of chronic family stress showed increased production of IL-4, IL-5, and IFN-gamma at times when they had experienced an acute event compared with times when they had not. These stress-related changes did not occur in asthmatic children with lower levels of chronic family stress, or in healthy controls. The combination of acute and chronic stress was also associated with increased asthma symptoms. CONCLUSION: These findings suggest that acute negative life events have a particularly strong impact among a subgroup of children with asthma who are under high chronic family stress. The heightened inflammatory profile in this group suggests an explanation for why children experiencing life stressors are at greater risk for asthma exacerbations.
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“negative social interactions involving friends, peers, teachers, or family members in daily life are associated with elevations in several markers of inflammatory activity, including CRP, IL-6, and a soluble receptor for TNFα”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Marin, Chen, Munch, & Miller, 2009
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Metadata
- Authors
- Marin, T. J., Chen, E., Munch, J. A., & Miller, G. E.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Marin, Teresa J.
- Venue
- Psychosomatic Medicine
- Published
- 2009-05
- Volume
- 71
- Issue
- 4
- Pages
- 378-384
- ISSN
- 0033-3174 (ISSN-L)
- PMC
- PMC2735247
- OpenAlex
- W2124090260
- Cited by
- 159
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 18
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL073975, R01HL073975)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- childhood asthma, psychological stress, acute stress, cytokines, IL-4, IL-5, IL-13, interferon-gamma, asthma exacerbations, immune response, mononuclear cell activation, asthma symptoms
- MeSH terms
- Acute Disease, Adolescent, Asthma, Child, Chronic Disease, Family Relations, Female, Follow-Up Studies, Humans, Interferon-gamma, Life Change Events, Male, Risk, Severity of Illness Index, Stress, Psychological, Interleukin-4, Interleukin-5, Th1 Cells, Th2 Cells, Interleukin-13, Anti-Asthmatic Agents
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