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Cited by 23Fibromyalgia and Chronic Fatigue Syndrome ResearchCancer-related cognitive impairment studiesRheumatoid Arthritis Research and Therapies

The Effect of Duloxetine Treatment on Cognition in Patients With Fibromyalgia

Mohs, Richard, Mease, Philip, Arnold, Lesley M., Wang, Fujun, Ahl, Jonna, Gaynor, Paula J., Wohlreich, Madelaine M.·2012·Psychosomatic Medicine
DOI 10.1097/psy.0b013e31825b9855
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Abstract

Objectives To determine the effect of duloxetine treatment on cognition in patients with fibromyalgia. Methods Cognitive testing was conducted in a subset of adult patients in a randomized, double-blind, placebo-controlled trial of duloxetine. Patients met the American College of Rheumatology criteria for fibromyalgia and had a score of 4 or higher on the Brief Pain Inventory 24-hour average pain severity item. Patients who consented to cognitive testing were randomized to duloxetine (n = 80) or placebo (n = 76). The primary end point was at Week 12. Speed of processing on tasks requiring visual attention, working memory, and executive function was assessed with a Symbol Digit Substitution Test and Trail-Making Test A and B. Episodic memory was tested using the Verbal Learning and Recall Test. The change from baseline to end point (last-observation-carried-forward analysis) was analyzed by an analysis of covariance model, which included baseline, treatment, investigator, and treatment-by-investigator interaction. Results Most of the patients were white (89%) women (92%), ranging in age from 21 to 88 years. Mean scores on the cognitive tests were within 2 SD of published scores for similar-aged participants in the general population, indicating no substantial impairment. Baseline-to-end point changes in cognitive scores did not differ significantly between duloxetine and placebo treatment groups. Conclusions Although scores differed somewhat from norms for age, substantial cog…

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Authors
Mohs, R., Mease, P., Arnold, L. M., Wang, F., Ahl, J., Gaynor, P. J., & Wohlreich, M. M.
Affiliations
Eli Lilly (United States) (US)
Corresponding author
Wohlreich, Madelaine M.
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-07
Volume
74
Issue
6
Pages
628-634
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e31825b9855
OpenAlex
W1998210533
Cited by
23
References
36
Citations by year
2025: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
duloxetine, fibromyalgia, cognitive function, cognitive impairment, processing speed, visual attention, working memory, executive function, episodic memory, Symbol Digit Substitution Test, Trail Making Test, antidepressant side effects
MeSH terms
Duloxetine Hydrochloride, Adult, Aged, Aged, 80 and over, Analysis of Variance, Attention, Cognition Disorders, Female, Fibromyalgia, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Pain, Pain Measurement, Placebos, Reaction Time, Severity of Illness Index, Thiophenes, Verbal Learning, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Young Adult, Executive Function, Memory, Episodic

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