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Cited by 28Hepatitis C virus researchHIV, Drug Use, Sexual RiskHIV/AIDS Research and Interventions

Early diagnosis and risk factors of acute hepatitis C in high-risk MSM on preexposure prophylaxis.

Gras, Julien, Mahjoub, Nadia, Charreau, Isabelle, Cotte, Laurent, Tremblay, Cécile, Chas, Julie, Raffi, François, Cua, Eric +6 more·2020·AIDS
DOI 10.1097/qad.0000000000002364
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Abstract

BACKGROUND: A high incidence of acute hepatitis C virus (HCV) (AHCV) infection has been reported among at-risk HIV-negative MSM. The optimal strategy for early diagnosis of AHCV in this population is not clearly defined. METHODS: In the ANRS IPERGAY PrEP trial, among high-risk HIV-negative MSM, HCV serology and serum alanine aminotransferase (ALT) were used for screening at enrollment and during follow-up. Behavioral risk factors were compared at baseline between participants who were diagnosed with AHCV during the study compared with those who did not. In participants with a positive HCV serology, we used stored sera to perform the following tests at diagnosis and on previous visits: HCV-antibodies rapid tests, plasma HCV viral load and HCV antigen immunoassay. We evaluated the sensitivity of each test for AHCV diagnosis. RESULTS: Among 429 enrolled participants, 14 were diagnosed with AHCV infection, with a median follow-up of 2.1 (interquartile range, 1.5-2.8) years. AHCV incidence was 1.40 per 100 person-years (95% confidence interval, 0.74-2.39). Patients with AHCV reported a significantly higher number of sexual acts and/or partners, and more frequent recreational drug use at baseline. At the prior visit before AHCV diagnosis (median of 2 months earlier), sensitivities of HCV RNA and HCV antigen tests were, respectively, 100 and 89%, whereas none of the patients had a positive serology, and only 25% had elevated ALT. CONCLUSION: HCV antigen and RNA tests were positive within a median of 2 months before the detection of antibodies and ALT elevation. These tests could be considered for HCV screening in high-risk MSM.

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Crossref · 10.1097/qad.0000000000002364

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  • Acute HCV infections have been reported among MSM on PrEP, increasing concerns that certain MSM might be at increased risk for incident HCV infection through condomless sexual intercourse with MSM with HCV infection.

    “More recently, acute HCV infections have been reported among MSM on PrEP, increasing concerns that certain MSM might be at increased risk for incident HCV infection through condomless sexual intercourse with MSM with HCV infection (1359,1360).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1360]

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Authors
Gras, J., Mahjoub, N., Charreau, I., Cotte, L., Tremblay, C., Chas, J., Raffi, F., Cua, E., Guillon, B., Guigue, N., Chaix, M. L., Meyer, L., Molina, J. M., & Delaugerre, C.
Affiliations
  • Inserm (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Hospices Civils de Lyon (FR)
  • Université Paris-Sud (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Gras, Julien
ORCID
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-01-01
Volume
34
Issue
1
Pages
47-52
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0000000000002364
OpenAlex
W2972244319
Cited by
28
References
26
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 8
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
acute hepatitis C, hepatitis C virus, men who have sex with men, pre-exposure prophylaxis, HCV screening, HCV RNA testing, HCV serology, alanine aminotransferase, diagnostic sensitivity, risk factors, recreational drug use, sexual behavior, HIV-negative MSM
MeSH terms
Acute Disease, Adult, Alanine Transaminase, Hepatitis C, Humans, Male, Risk Factors, RNA, Viral, HIV Infections, Homosexuality, Male, Hepatitis C Antigens, Hepatitis C Antibodies, Viral Load, Early Diagnosis, Pre-Exposure Prophylaxis

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