The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
Abstract
OBJECTIVE: To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population. DESIGN: : National observational HIV cohort in the Netherlands. METHODS: Four thousand, six hundred and twelve patients diagnosed with HIV between 1998 and 2007 and still antiretroviral therapy-naive as of 24 weeks after diagnosis were selected. Progression to death compared to the age and sex-matched general population was studied with a multivariate hazards model in 4174 (90.5%) patients without AIDS events at 24 weeks. Life expectancy and number of life years lost were calculated using the predicted survival distribution. RESULTS: During 17 580 person-years of follow-up since 24 weeks after diagnosis [median follow-up 3.3 years, interquartile range (IQR) 1.6-5.8], 118 deaths occurred, yielding a mortality rate of 6.7 [95% confidence interval (CI) 5.5-8.0] per 1000 person-years. Median CD4 cell counts at 24 weeks were 480 cells/microl (IQR 360-650). According to the model, the median number of years lived from age 25 was 52.7 (IQR 44.2-59.3; general population 53.1) for men and 57.8 (49.2-63.7; 58.1) for women without CDC-B event. The number of life years lost varied between 0.4 if diagnosed with HIV at age 25 and 1.4 if diagnosed at age 55; for patients with a CDC-B event this range was 1.8-8.0 years. CONCLUSION: The life expectancy of asymptomatic HIV-infected patients who are still treatment-naive and have not experienced a CDC-B or C event at 24 weeks after diagnosis approaches that of non-infected individuals. However, follow-up time is short compared to the expected number of years lived.
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Self-citationEgger, M., May, M., Chêne, G., Phillips, A. N., Ledergerber, B., Dabis, F., Costagliola, D., Monforte, A. D., de Wolf, F., Reiss, P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09411-4 · Cited by 1,525
Self-citationDecline in the AIDS and death rates in the EuroSIDA study: an observational study
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Serrano-Villar, S., Sainz, T., Lee, S. A., Hunt, P. W., Sinclair, E., Shacklett, B. L., Ferre, A. L., Hayes, T. L., Somsouk, M., Hsue, P. Y., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004078 · Cited by 611
Life expectancy living with HIV: recent estimates and future implications
Nakagawa, F., May, M., & Phillips, A. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32835ba6b1 · Cited by 373
May, M., Gompels, M., Delpech, V., Porter, K., Post, F., Johnson, M., Dunn, D., Palfreeman, A., Gilson, R., Gazzard, B., et al. (2011) · BMJ · doi:10.1136/bmj.d6016 · Cited by 363
HIV reservoirs: pathogenesis and obstacles to viral eradication and cure
Chun, T.-W., & Fauci, A. S. (2012) · AIDS · doi:10.1097/qad.0b013e328353f3f1 · Cited by 175
Joshi, S., Muwonge, R., Kulkarni, V., Mandolkar, M., Lucas, E., Pujari, S., Sankaranarayanan, R., & Basu, P. (2023) · International Journal of Cancer · doi:10.1002/ijc.34221 · Cited by 12
Metadata
- Authors
- van Sighem, A., Gras, L., Reiss, P., Brinkman, K., & de Wolf, F.
- Venue
- AIDS
- Published
- 2010-06-19
- Volume
- 24
- Issue
- 10
- Pages
- 1527-1535
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2042498919
- Cited by
- 398
- References
- 32
- FWCI
- 23.06
- Type
- journal article
- Language
- en
- Open access
- closed
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