Cited by 363HIV/AIDS Research and InterventionsHIV-related health complications and treatmentsHIV Research and Treatment

Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study

Open access
May, M., Gompels, M., Delpech, V., Porter, K., Post, F., Johnson, M., Dunn, D., Palfreeman, A. +13 more·2011·BMJ

Abstract

OBJECTIVES: To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy. DESIGN: Cohort study. SETTING: Outpatient HIV clinics throughout the United Kingdom. Population Adult patients from the UK Collaborative HIV Cohort (UK CHIC) Study with CD4 count ≤ 350 cells/mm(3) at start of antiretroviral therapy in 1996-2008. MAIN OUTCOME MEASURES: Life expectancy at the exact age of 20 (the average additional years that will be lived by a person after age 20), according to the cross sectional age specific mortality rates during the study period. RESULTS: 1248 of 17,661 eligible patients died during 91,203 person years' follow-up. Life expectancy (standard error) at exact age 20 increased from 30.0 (1.2) to 45.8 (1.7) years from 1996-9 to 2006-8. Life expectancy was 39.5 (0.45) for male patients and 50.2 (0.45) years for female patients compared with 57.8 and 61.6 years for men and women in the general population (1996-2006). Starting antiretroviral therapy later than guidelines suggest resulted in up to 15 years' loss of life: at age 20, life expectancy was 37.9 (1.3), 41.0 (2.2), and 53.4 (1.2) years in those starting antiretroviral therapy with CD4 count <100, 100-199, and 200-350 cells/mm(3), respectively. CONCLUSIONS: Life expectancy in people treated for HIV infection has increased by over 15 years during 1996-2008, but is still about 13 years less than that of the UK population. The higher life expectancy in women is magnified in those with HIV. Earlier diagnosis and subsequent timely treatment with antiretroviral therapy might increase life expectancy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/bmj.d6016

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 40 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
May, M., Gompels, M., Delpech, V., Porter, K., Post, F., Johnson, M., Dunn, D., Palfreeman, A., Gilson, R., Gazzard, B., Hill, T., Walsh, J., Fisher, M., Orkin, C., Ainsworth, J., Bansi, L., Phillips, A., Leen, C., Nelson, M., Anderson, J., & Sabin, C.
Affiliations
  • University of Bristol (GB)
  • North Bristol NHS Trust (GB)
  • University College London (GB)
  • King's College London (GB)
  • The Royal Free Hospital (GB)
  • Medical Research Council (GB)
  • Leicester Royal Infirmary (GB)
  • Mortimer Market Centre (GB)
  • Chelsea and Westminster Hospital (GB)
  • Imperial College Healthcare NHS Trust (GB)
  • Brighton and Sussex University Hospitals NHS Trust (GB)
  • Queen Mary University of London (GB)
  • North Middlesex Hospital (GB)
  • Western General Hospital (GB)
  • Homerton University Hospital (GB)
Corresponding author
May, M.
Venue
BMJ
Publisher
BMJ
Published
2011-10-11
Volume
343
Issue
oct11 2
Pages
d6016-d6016
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
OpenAlex
W2008613145
Cited by
363
References
40
Citations by year
2026: 9 · 2025: 12 · 2024: 11 · 2023: 21 · 2022: 21 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 26 · 2017: 16 · 2016: 42 · 2015: 39 · 2014: 31 · 2013: 34 · 2012: 30
FWCI
22.54
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • BMJ (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • Figshare (submittedVersion, cc-by)
  • ResearchOnline (submittedVersion)
  • Sussex Research Online (University of Sussex) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc)
  • Bristol Research (University of Bristol) (submittedVersion)
  • ResearchOnline (Glasgow Caledonian University) (submittedVersion, cc-by-nc)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
HIV-1, life expectancy, delayed diagnosis, late treatment, antiretroviral therapy, CD4 count, mortality, sex differences
MeSH terms
Adult, Aged, Cooperative Behavior, Drug Therapy, Combination, Female, United Kingdom, Humans, Life Expectancy, Male, Middle Aged, Time Factors, Cohort Studies, HIV-1, HIV Infections, Practice Guidelines as Topic, CD4 Lymphocyte Count, Anti-HIV Agents, Young Adult, Delayed Diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review