The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Colloidal Gold Nanoparticles as a Blood-Pool Contrast Agent for X-ray Computed Tomography in Mice
Abstract
OBJECTIVES: To present the pharmacokinetics and computed tomographic imaging efficacy of colloidal gold nanoparticles (AuNPs) as a blood-pool agent for x-ray computed tomography (CT). METHODS AND MATERIALS: To prepare the colloidal AuNPs, gold nanocrystals were modified using sulfhydrated polyethylene glycol (PEG). Cytotoxicity and histopathologic tests were carried out for toxicity evaluation. Six adult Balb/c mice underwent microcomputed tomography scans after injection of colloidal AuNPs (2.5 micromol Au/g body weight). Four mice with HT-1080 tumors were imaged for visualization of the tumor vasculature. RESULTS: The PEG coated colloidal AuNPs appeared as spherical nanoparticles with 38-nm diameters. The AuNPs-PEG showed a biocompatibility without toxicity in the mice. We identified a stable imaging window for visualizing the vasculature system, immediately to 24 hours after injection. Microcomputed tomography imaging using AuNPs-PEG clearly visualized the tumor vascular structures. CONCLUSION: Colloidal AuNPs show potential as a blood-pool agent for x-ray CT imaging.
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Gold Nanomaterials at Work in Biomedicine
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Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas
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Targeting nanoparticles to cancer
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Targeted Gold Nanoparticles Enable Molecular CT Imaging of Cancer
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Luminescent Gold Nanoparticles with Efficient Renal Clearance
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Metadata
- Authors
- Cai, Q.-Y., Kim, S. H., Choi, K. S., Kim, S. Y., Byun, S. J., Kim, K. W., Park, S. H., Juhng, S. K., & Yoon, K.-H.
- Venue
- Investigative Radiology
- Published
- 2007-12
- Volume
- 42
- Issue
- 12
- Pages
- 797-806
- ISSN
- 0020-9996 (ISSN-L)
- OpenAlex
- W2038820733
- Cited by
- 301
- References
- 17
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cai, Q.-Y., Kim, S. H., Choi, K. S., Kim, S. Y., Byun, S. J., Kim, K. W., Park, S. H., Juhng, S. K., & Yoon, K.-H. (2007). Colloidal Gold Nanoparticles as a Blood-Pool Contrast Agent for X-ray Computed Tomography in Mice. Investigative Radiology. https://doi.org/10.1097/rli.0b013e31811ecdcd
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