The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas
Open accessAbstract
Plasmonic nanomaterials have the opportunity to considerably improve the specificity of cancer ablation by i.v. homing to tumors and acting as antennas for accepting externally applied energy. Here, we describe an integrated approach to improved plasmonic therapy composed of multimodal nanomaterial optimization and computational irradiation protocol development. We synthesized polyethylene glycol (PEG)–protected gold nanorods (NR) that exhibit superior spectral bandwidth, photothermal heat generation per gram of gold, and circulation half-life in vivo (t1/2, ∼17 hours) compared with the prototypical tunable plasmonic particles, gold nanoshells, as well as ∼2-fold higher X-ray absorption than a clinical iodine contrast agent. After intratumoral or i.v. administration, we fuse PEG-NR biodistribution data derived via noninvasive X-ray computed tomography or ex vivo spectrometry, respectively, with four-dimensional computational heat transport modeling to predict photothermal heating during irradiation. In computationally driven pilot therapeutic studies, we show that a single i.v. injection of PEG-NRs enabled destruction of all irradiated human xenograft tumors in mice. These studies highlight the potential of integrating computational therapy design with nanotherapeutic development for ultraselective tumor ablation. [Cancer Res 2009;69(9):3892–900]
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Cites
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
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Cited by
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523
Gold Nanomaterials at Work in Biomedicine
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Gold nanoparticles: opportunities and challenges in nanomedicine
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Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease
Li, M., Yang, X., Ren, J., Qu, K., & Qu, X. (2012) · Advanced Materials · doi:10.1002/adma.201104864 · Cited by 535
Metadata
- Authors
- von Maltzahn, G., Park, J.-H., Agrawal, A., Bandaru, N. K., Das, S. K., Sailor, M. J., & Bhatia, S. N.
- Venue
- Cancer Research
- Published
- 2009-04-30
- Volume
- 69
- Issue
- 9
- Pages
- 3892-3900
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2161552291
- Cited by
- 1,051
- References
- 33
- FWCI
- 42.12
- Type
- journal article
- Language
- en
- Open access
- green
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- von Maltzahn, G., Park, J.-H., Agrawal, A., Bandaru, N. K., Das, S. K., Sailor, M. J., & Bhatia, S. N. (2009). Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas. Cancer Research. https://doi.org/10.1158/0008-5472.can-08-4242
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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